Sickle-cell disease risk factors: Difference between revisions

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==Risk Factors==
==Risk Factors==
Besides race, there are no specific risk factors for sickle cell disease. Sickle cell disease is a monogenetic disease, meaning that one gene mutations causes the disease. Thus environmental factors do not play a major role in acquisition of the disease. The disease occurs at birth after a person inherits 2 sickle cell alleles, one from each parent. Certain endemic regions contain a high prevalence of sickle cell alleles.<ref name="pmid25143960">{{cite journal| author=Makani J, Ofori-Acquah SF, Nnodu O, Wonkam A, Ohene-Frempong K| title=Sickle cell disease: new opportunities and challenges in Africa. | journal=ScientificWorldJournal | year= 2013 | volume= 2013 | issue=  | pages= 193252 | pmid=25143960 | doi=10.1155/2013/193252 | pmc=3988892 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25143960  }} </ref>
Besides race, there are no specific risk factors for sickle cell disease. Sickle cell disease is a monogenetic disease, meaning that one gene mutations causes the disease. Thus environmental factors do not play a major role in acquisition of the disease. The disease occurs at birth after a person inherits 2 sickle cell alleles, one from each parent. Certain endemic regions contain a high prevalence of sickle cell alleles.<ref name="pmid25143960">{{cite journal| author=Makani J, Ofori-Acquah SF, Nnodu O, Wonkam A, Ohene-Frempong K| title=Sickle cell disease: new opportunities and challenges in Africa. | journal=ScientificWorldJournal | year= 2013 | volume= 2013 | issue=  | pages= 193252 | pmid=25143960 | doi=10.1155/2013/193252 | pmc=3988892 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25143960 }} </ref> The degree of fetal hemoglobin production is related to the severe of disease: higher fetal hemoglobin confers lower disease morbidity and thus is a favorable risk factor/modifier.<ref name="pmid22887019">{{cite journal| author=Kutlar A, Ataga K, Reid M, Vichinsky EP, Neumayr L, Blair-Britt L et al.| title=A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease. | journal=Am J Hematol | year= 2012 | volume= 87 | issue= 11 | pages= 1017-21 | pmid=22887019 | doi=10.1002/ajh.23306 | pmc=3904792 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22887019 }} </ref>


There are some risk factors for precipitation of sickle cell crises, such as dehydration, low oxygen levels, medication nonadherence.
There are some risk factors for precipitation of sickle cell crises, such as dehydration, low oxygen levels, medication nonadherence.

Revision as of 03:14, 25 September 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shyam Patel [2]

Overview

There are no specific risk factors for sickle cell disease.

Risk Factors

Besides race, there are no specific risk factors for sickle cell disease. Sickle cell disease is a monogenetic disease, meaning that one gene mutations causes the disease. Thus environmental factors do not play a major role in acquisition of the disease. The disease occurs at birth after a person inherits 2 sickle cell alleles, one from each parent. Certain endemic regions contain a high prevalence of sickle cell alleles.[1] The degree of fetal hemoglobin production is related to the severe of disease: higher fetal hemoglobin confers lower disease morbidity and thus is a favorable risk factor/modifier.[2]

There are some risk factors for precipitation of sickle cell crises, such as dehydration, low oxygen levels, medication nonadherence.

References

  1. Makani J, Ofori-Acquah SF, Nnodu O, Wonkam A, Ohene-Frempong K (2013). "Sickle cell disease: new opportunities and challenges in Africa". ScientificWorldJournal. 2013: 193252. doi:10.1155/2013/193252. PMC 3988892. PMID 25143960.
  2. Kutlar A, Ataga K, Reid M, Vichinsky EP, Neumayr L, Blair-Britt L; et al. (2012). "A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease". Am J Hematol. 87 (11): 1017–21. doi:10.1002/ajh.23306. PMC 3904792. PMID 22887019.

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