Secondary amyloidosis risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
The most potent risk factor in the development of secondary amyloidosis is a persistent inflammatory disorders.
Risk Factors
- The most potent risk factor in the development of secondary amyloidosis is a persistent inflammatory disorders.[1]
- chronic infections and inflammatory arthritis are among the most common risk factors.[2][3][4]
- Other possible risk factors include:
- Obesity
- Aging
- SAA1 gene alleles
- Monogenic periodic fever syndromes, such as:
- FMF
- TNF Receptor associated periodic syndrome (TRAPS)
- Cryopyrin-associated periodic fever syndrome
- Mevalonate kinase deficiency
- Tuberculosis
- Leprosy
- Whipple Disease
- Osteomyelitis
- Chronic pyelonephritis
- Subacute bacterial endocarditis
- Chronic cutaneous ulcers
- Conditions Predisposing to Chronic Infections include:
- Cystic fibrosis
- Bronchiectasis
- Kartagener syndrome
- Epidermolysis bullosa
- Injected drug abuse
- Jejuno-ileal bypass
- Paraplegia
- Sickle cell anemia
- Immunodeficiency
- Common variable immunodeficiency
- Cyclic neutropenia
- Hyperimmunoglobulin M syndrome
- Hypogammaglobulinemia
- Sex-linked agammaglobulinemia
- Human immunodeficiency virus/AIDS
- Neoplasia
- Adenocarcinoma
Basal cell carcinoma Carcinoid tumor Castleman disease Gastrointestinal stromal tumor Hairy cell leukemia Hepatic adenoma Hodgkin disease
- Mesothelioma
- Renal cell carcinoma
- Sarcoma
- Inflammatory Arthritis
- Adult-onset Still disease
- Ankylosing spondylitis
- Juvenile idiopathic arthritis
- Psoriatic arthropathy
- Reiter syndrome
- Rheumatoid arthritis
- Gout
- Systemic Vasculitis
- Antineutrophil cytoplasmic antibody-associated vasculitis
- Behcet disease
- Giant cell arteritis
- Polyarteritis nodosa
- Polymyalgia rheumatica
- Systemic lupus erythematosus
Takayasu arteritis
- Inflammatory Bowel Disease
- Ulcerative colitis
- Crohn diseases
- Others include:
- Atrial myxoma
- Inflammatory abdominal aortic aneurism
- Retroperitoneal fibrosis
- SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome
- Sarcoidosis
- Sinus histiocytosis with massive lymphadenopathy
References
- ↑ Koivuniemi, Riitta; Paimela, Leena; Suomalainen, Risto; Törnroth, Tom; Leirisalo-Repo, Marjatta (2009). "Amyloidosis is frequently undetected in patients with rheumatoid arthritis". Amyloid. 15 (4): 262–268. doi:10.1080/13506120802524676. ISSN 1350-6129.
- ↑ Blank, Norbert; Hegenbart, Ute; Dietrich, Sascha; Brune, Maik; Beimler, Jörg; Röcken, Christoph; Müller-Tidow, Carsten; Lorenz, Hanns-Martin; Schönland, Stefan O. (2018). "Obesity is a significant susceptibility factor for idiopathic AA amyloidosis". Amyloid. 25 (1): 37–45. doi:10.1080/13506129.2018.1429391. ISSN 1350-6129.
- ↑ van der Hilst, J. C. H.; Yamada, T.; Op den Camp, H. J. M.; van der Meer, J. W. M.; Drenth, J. P. H.; Simon, A. (2008). "Increased susceptibility of serum amyloid A 1.1 to degradation by MMP-1: potential explanation for higher risk of type AA amyloidosis". Rheumatology. 47 (11): 1651–1654. doi:10.1093/rheumatology/ken371. ISSN 1462-0324.
- ↑ Papa, Riccardo; Doglio, Matteo; Lachmann, Helen J.; Ozen, Seza; Frenkel, Joost; Simon, Anna; Neven, Bénédicte; Kuemmerle-Deschner, Jasmin; Ozgodan, Huri; Caorsi, Roberta; Federici, Silvia; Finetti, Martina; Trachana, Maria; Brunner, Jurgen; Bezrodnik, Liliana; Pinedo Gago, Mari Carmen; Maggio, Maria Cristina; Tsitsami, Elena; Al Suwairi, Wafaa; Espada, Graciela; Shcherbina, Anna; Aksu, Guzide; Ruperto, Nicolino; Martini, Alberto; Ceccherini, Isabella; Gattorno, Marco (2017). "A web-based collection of genotype-phenotype associations in hereditary recurrent fevers from the Eurofever registry". Orphanet Journal of Rare Diseases. 12 (1). doi:10.1186/s13023-017-0720-3. ISSN 1750-1172.