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{| style="border: 2px solid #4479BA; align="left"
{| style="border: 2px solid #4479BA; align="left"
! colspan=2 style="width: 400px; background: #4479BA; text-align: left;"|{{fontcolor|#FFF|Hepatic Laboratory Abnormalities—Study GS-US-540-5773}}
! style="width: 400px; background: #4479BA; text-align: left;"|{{fontcolor|#FFF|Body weight}}
! style="width: 200px; background: #4479BA; text-align: center;"|{{fontcolor|#FFF|Remdesivir for 5 Days}}
! style="width: 200px; background: #4479BA; text-align: center;"|{{fontcolor|#FFF|Recommended dosage form}}
! style="width: 200px; background: #4479BA; text-align: center;"|{{fontcolor|#FFF|Remdesivir for 10 Days}}
! style="width: 200px; background: #4479BA; text-align: center;"|{{fontcolor|#FFF|Loading dose on Day 1}}
! style="width: 200px; background: #4479BA; text-align: center;"|{{fontcolor|#FFF|Total}}
! style="width: 200px; background: #4479BA; text-align: center;"|{{fontcolor|#FFF|Maintenance dose from Day 2}}
|-
|-
| rowspan=2 style="padding: 0 5px; background: #F5F5F5; text-align: left;" | ALT Increased
| style="padding: 0 5px; background: #F5F5F5; text-align: left;" | 3.5 kg to less than 40 kg
| style="padding: 0 5px; background: #F5F5F5; text-align: left;" | Grade 3
| style="padding: 0 5px; background: #F5F5F5; text-align: left;" | Remdesivir Lyophilized Powder for Injection Only
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 8/194 (4%)
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 5 mg/kg
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 11/191 (6%)
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 2.5 mg/kg
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 19/385 (5%)
|-
|-
| style="padding: 0 5px; background: #F5F5F5; text-align: left;" | Grade 4
| style="padding: 0 5px; background: #F5F5F5; text-align: left;" | 40 kg and higher
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 4/194 (2%)
| style="padding: 0 5px; background: #F5F5F5; text-align: left;" | Remdesivir Lyophilized Powder for Injection or Remdesivir Injection
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 5/191 (3%)
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 200 mg
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 9/385 (2%)
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 100 mg
|-
| rowspan=2 style="padding: 0 5px; background: #F5F5F5; text-align: left;" | AST Increased
| style="padding: 0 5px; background: #F5F5F5; text-align: left;" | Grade 3
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 11/194 (6%)
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 7/190 (4%)
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 18/384 (5%)
|-
| style="padding: 0 5px; background: #F5F5F5; text-align: left;" | Grade 4
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 3/194 (2%)
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 4/190 (2%)
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 7/384 (2%)
|-
| rowspan=2 style="padding: 0 5px; background: #F5F5F5; text-align: left;" | Total Bilirubin Increased
| style="padding: 0 5px; background: #F5F5F5; text-align: left;" | Grade 3
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 1/193 (1%)
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 3/190 (2%)
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 4/383 (1%)
|-
| style="padding: 0 5px; background: #F5F5F5; text-align: left;" | Grade 4
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 0
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 1/190 (1%)
| style="padding: 0 5px; background: #F5F5F5; text-align: center;" | 1/383 (<1%)
|-
|-
|}
|}

Revision as of 21:44, 2 July 2020

Body weight Recommended dosage form Loading dose on Day 1 Maintenance dose from Day 2
3.5 kg to less than 40 kg Remdesivir Lyophilized Powder for Injection Only 5 mg/kg 2.5 mg/kg
40 kg and higher Remdesivir Lyophilized Powder for Injection or Remdesivir Injection 200 mg 100 mg