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==Astrocytoma==
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! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF|'''Tumor'''}}
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Types of glioblastoma multiforme}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|'''History'''}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Genes}}
! style="background: #4479BA; width: 450px;" | {{fontcolor|#FFF|'''Symptoms'''}}
! style="background: #4479BA; width: 450px;" | {{fontcolor|#FFF|'''Characteristic Lab Findings'''}}
! style="background: #4479BA; width: 450px;" | {{fontcolor|#FFF|'''Imaging'''}}
! style="background: #4479BA; width: 450px;" | {{fontcolor|#FFF|'''Biopsy Findings'''}}
 
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'''Anaplastic Astrocytoma'''
:Primary​
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*
*
*
*
*
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* Seizures
*''[[Mdm2]]''
* Headache
*''[[PTEN]]''
* Neurologic deficits
*Gene on chromosome 10p
* Changes in mental status
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:Secondary
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*  
*''IDH1''
*''[[p53]]''
*Gene on chromosome 10q
*Gene on chromosome 17p
*Gene on chromosome 19q
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:Classic
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* CT scan shows regions of low attenuation with positive mass effect
*''[[EGFR]]''
* Enhancement on CT is variable
*
* 
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'''Oligoastrocytoma'''
:Proneural
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*  
*''[[TP53]]''
*  
*''PDGFRA''
*  
*''IDH1''
*
*
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*
*
*
*
*
*
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* Hypervascularity with diffuse multiple metastatic nodulation
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* Solid sheets
* Uniform cuboidal cells
* Centrally located nuclei
* Stippled chromatin
* Granular eosinophilic cytoplasm
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'''Pilocytic Astrocytoma'''
:Mesenchymal
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* Epigastric abdominal pain
* Diarrhea
* Heartburn
* Hematemesis
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* Elevated serum gastrin level
* Positive secretin stimulation test
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* Small hypoattenuating nodule {{withorwithout}} calcification
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* Lobular-trabecular pattern
*''[[NF-1]]''
* Gastrin+ tumor cells
* Infiltration of Brunner glands
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|-
  ! Disease
  ! History and Symptoms
  ! Physical Examination
  ! Laboratory Findings
  ! Imaging
  ! Other Diagnostic Tests
  ! Features on Biopsy
  !
  !
  !
|-
  |'''Pilocytic Astrocytoma'''
  |
  |
  |
  |
  |
  |
  |
  |
|-
  |'''Diffuse Astrocytoma'''
  |Acute
  |10-20 minutes
  |Same as stable angina but often more severe
  |Same as stable angina
  |Same as stable angina but occurs with lower levels of exertion & rest
  |Same as stable angina
  |Same as stable angina
  |Same as stable angina
|-
  |'''Anaplastic Astrocytoma'''
  |Acute
  |Commonly > 20 minutes
  |Same as stable angina but often more severe
  |Same as stable angina
  |Same as stable angina but occurs with lower levels of exertion & rest
  |Usually unrelieved by nitroglycerine and rest
  |Same as stable angina
  |Same as stable angina
|-
  |'''[[Glioblastoma]]'''
  |Acute, recurrent episodes of angina
  |Same as stable angina
  |Same as stable angina
  |Same as stable angina
  |Same as stable angina
  |Same as stable angina
  |Same as stable angina
  |Not specific
|-
  |'''[[Oligodendroglioma]]'''
  |Sudden severe progressive pain (common) or chronic (rare)
  |Variable
  |Tearing, ripping sensation, knife like
  |Depends on area of dissection
  |Variable
  |Unrelenting pain, unrelieved by nitroglycerine and rest
  |Radiating to back, between shoulder blades (dissection in ascending aorta)
  |Trauma, Surgical manipulation, pregnancy, [[hypertension]], [[connective tissue disease]] like [[marfan's syndrome]] (cystic medial degeneration)
|-
  |'''[[Ependymoma]]'''
  |Acute or subacute
  |May last for hours to days
  |Sharp, localized
  |Retrosternal
  |Increases with coughing, deep breathing, supine position
  |Relieved by sitting up and leaning forward
  |Radiation to shoulder, neck, back abdomen
  |Not specific
|-
  |'''[[]]'''
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Revision as of 16:41, 19 November 2015
Types of glioblastoma multiforme Genes
Primary​
Secondary
  • IDH1
  • p53
  • Gene on chromosome 10q
  • Gene on chromosome 17p
  • Gene on chromosome 19q
Classic
Proneural
Mesenchymal
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