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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2]

Differential NHL

Diseases Clinical manifestations Para-clinical findings Pathogonomic finding
Symptoms
Lab Findings Images Biopsy

Histopathology

Lymphadenopathy Fever Weight loss Night Sweats Rash Other symptoms Lab 1 Imaging 1
Non-Hodgkins lymphoma
  • painless
  • localized or generalized
+ + + +
  • Presents with "B" symptoms
INFECTIONS Bacteria Syphilis
  • painless
  • localized
+ - - + Primary syphilis:
  • Chancer

Secondary syphilis:

Tertiary syphilis

  • Gumma
  • Organ system involvement
  • Nontreponemal tests (e.g., VDRLand RPR )
  • Treponemal tests (e.g. FTA-ABS, the TP-PA assay
Painless clean base chancre.
Brucellosis
  • Painful
+ - - +
  • Abdominal pain
  • hepatosplenomegaly
  • arthritis
  • Brucella is most commonly isolated from blood cultures
Night sweats, often with characteristic smell, likened to wet hay
Viral infectious mononucleosis
  • painful
+ - - +
CMV + - - +
HIV
  • Painful or painless
- + - -
Cat scratch disease + - - +
Mycobacteria Tuberculosis
  • Painful
+ + + + Gohn's focus
Parasite Toxoplasmosis - -
Diseases Lymphadenopathy Fever Weight loss Night sweats Rash Other symptoms Lab 1 Imaging 1 Biopsy

Histopathology

Pathogonomical

findings

AUTOIMMUNE Systemic lupus erythematosus painless - - - + Malar rash and photosensitivity
Sjögren's syndrome Painless - - - + Keratoconjunctivitis sicca
Sarcoidosis painless - - - - -
Diseases Lymphadenopathy Fever Weight loss Night sweats Rash Other symptoms Lab 1 Imaging 1 Biopsy

Histopathology

Pathogonomical

findings

NEOPLASIA Hodgkin's disease painless - - - + Malar rash and photosensitivity
Chronic lymphocytic leukemia Painless - - - + Keratoconjunctivitis sicca
Small cell carcinoma of the lung painless - - -
Melanoma painless - - -
Lymphomatoid granulomatosis painless - - -
Angioimmunoblastic lymphadenopathy painless - - -
NEOPLASIA Giant lymph node hyperplasia (Castleman disease) painless - - -

References