Sandbox : anmol
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Lyme disease Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Abnormal magnetic resonance imaging (MRI) findings are often seen in both early and late Lyme disease. Diffuse white matter pathology can disrupt these ubiquitous gray matter connections and could account for deficits in attention, memory, visuospatial ability, complex cognition, and emotional status. White matter disease may have a greater potential for recovery than gray matter disease, perhaps because neuronal loss is less common,
MRI
Abnormal magnetic resonance imaging (MRI) findings are often seen in both early and late Lyme disease. MRI scans of patients with neurologic Lyme disease may demonstrate punctated white matter lesions on T2-weighted images, similar to those seen in demyelinating or inflammatory disorders such as multiple sclerosis, systemic lupus erythematosus (SLE), or cerebrovascular disease.[1] Cerebral atrophy and brainstem neoplasm has been indicated with Lyme infection as well.[2]
Diffuse white matter pathology can disrupt these ubiquitous gray matter connections and could account for deficits in attention, memory, visuospatial ability, complex cognition, and emotional status. White matter disease may have a greater potential for recovery than gray matter disease, perhaps because neuronal loss is less common. Spontaneous remission can occur in multiple sclerosis, and resolution of MRI white matter hyper-intensities, after antibiotic treatment, has been observed in Lyme disease.[3]
References
- ↑ Fallon, BA (2000). Review of Lyme Neuroborreliosis. 3th International Scientific Conference on Lyme Disease and other Tick-borne Disorders.
- ↑ Kalina P, Decker A, Kornel E, Halperin JJ (2005). "Lyme disease of the brainstem". Neuroradiology. 47 (12): 903–7. doi:10.1007/s00234-005-1440-2. PMID 16158278.
- ↑ Fallon BA, Keilp J, Prohovnik I, Heertum RV, Mann JJ (2003). "Regional cerebral blood flow and cognitive deficits in chronic lyme disease". The Journal of neuropsychiatry and clinical neurosciences. 15 (3): 326–32. PMID 12928508.