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{{CMG}}; {{AE}} {{Anmol}}
{{CMG}}; {{AE}} {{Anmol}}


==Differential NHL==
==Tables==
 
{| class="wikitable"
{|
|+
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
!Diagnosis
! colspan="3" rowspan="4" |Diseases
!Lab findings
| colspan="6" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Clinical manifestations'''
!
! colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para-clinical findings
!
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pathogonomic finding
|-
|-
| colspan="6" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Symptoms'''
!
!
!
!
|-
|-
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Biopsy
Histopathology
|-
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy
! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Weight loss
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Night Sweats
! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Rash
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other symptoms
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Immunochemistry
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Blood work
|-
| colspan="3" |Non-Hodgkins lymphoma
| style="background: #F5F5F5; padding: 5px;" |
* painless
* localized or generalized
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" |
* Presents with "B" symptoms
* Constant [[Fatigue (physical)|fatigue]]
* [[Shortness of breath]] and Cough
* [[Abdominal pain]] or swelling
* [[Constipation]]
* [[Nausea]] and[[vomiting]].
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
|-
| rowspan="8" |'''INFECTIONS'''
| rowspan="2" style="background: #DCDCDC; padding: 5px; text-align: center;" |Bacteria
|Syphilis
| style="background: #F5F5F5; padding: 5px;" |
* painless
* localized
| +
|<nowiki>-</nowiki>
| -
| +
|Primary syphilis:
* Chancer
Secondary syphilis:
* Rash
* Condylomata lata
* Patchy [[alopecia]]
Tertiary syphilis
* Gumma
* Organ system involvement
|
* Darkfield microscopy to detect ''[[T. pallidum]].''
* Nontreponemal tests (e.g., [[VDRL]]<nowiki/>and [[RPR]] )
* Treponemal tests (e.g. [[FTA-ABS]], the TP-PA assay
|
|
|Painless clean base chancre.
|-
|Brucellosis
| style="background: #F5F5F5; padding: 5px;" |
* Painful
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" |
* Abdominal pain
* hepatosplenomegaly
* arthritis
| style="background: #F5F5F5; padding: 5px;" |
* [[Brucella|''Brucella'']] is most commonly isolated from blood cultures
* positive titer of anti-[[Brucella|b''rucella'']] [[antibodies]] on serological testing
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |[[Night sweats]], often with characteristic smell, likened to wet hay
|-
| rowspan="4" |Viral
|infectious mononucleosis
|
* painful
|<nowiki>+</nowiki>
|<nowiki>-</nowiki>
|<nowiki>-</nowiki>
|<nowiki>+</nowiki>
|
* low-grade [[fever]]<nowiki/>without [[chills]]
* [[sore throat]],
* white patches on [[tonsils]] and back of the throat,
* [[muscle weakness]]
* [[fatigue]]
* [[petechial hemorrhage]]
|
|
|
|
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|
|
|-
|-
|CMV
|
|<nowiki>+</nowiki>
|<nowiki>-</nowiki>
|<nowiki>-</nowiki>
|<nowiki>+</nowiki>
|
|
|
|
|
Line 128: Line 26:
|
|
|-
|-
|HIV
|
|
* Painful or painless
|<nowiki>-</nowiki>
|<nowiki>+</nowiki>
|<nowiki>-</nowiki>
|<nowiki>-</nowiki>
|
|
|
|
|
|
|
|
|-
|Cat scratch disease
|
|<nowiki>+</nowiki>
|<nowiki>-</nowiki>
|<nowiki>-</nowiki>
|<nowiki>+</nowiki>
|
|
|
|
|
|-
|Mycobacteria
|Tuberculosis
|
* Painful
|<nowiki>+</nowiki>
|<nowiki>+</nowiki>
|<nowiki>+</nowiki>
|<nowiki>+</nowiki>
|
* Prior history of residence in an endemic area.
* Chronic [[cough]], [[weight loss]], [[hemoptysis]]
|
* [[PCR]] of [[CSF]] for [[tuberculosis]]
* Mycobacterial culture of CSF
* Brain biopsy for [[acid-fast bacilli]] staining
* Culture and acid stain positive for [[acid-fast bacilli]]
* CXR shows cavitations.
|
|
|Gohn's focus
|-
|Parasite
|Toxoplasmosis
|
|
|<nowiki>-</nowiki>
|<nowiki>-</nowiki>
|
|
|
|
|
|
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
! colspan="3" |Diseases
!Lymphadenopathy
! colspan="1" rowspan="1" |Fever
!Weight loss
!Night sweats
! colspan="1" rowspan="1" |Rash
!Other symptoms
!Immunochemistry
!Blood work
!Biopsy
Histopathology
!Pathogonomical
findings
|-
| rowspan="3" |'''AUTOIMMUNE'''
| colspan="2" style="background: #DCDCDC; padding: 5px; text-align: center;" |Systemic lupus erythematosus
| style="background: #F5F5F5; padding: 5px;" |painless
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* [[ESR]]
* [[CRP]]<nowiki/>elevated
* [[ANA]] positive
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |[[Malar rash]] and [[photosensitivity]]
|-
| colspan="2" style="background: #DCDCDC; padding: 5px; text-align: center;" |Sjögren's syndrome
| style="background: #F5F5F5; padding: 5px;" |Painless
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" |
* [[Xerosis]]
* Scaly skin
* Annular [[erythema]]
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |[[Keratoconjunctivitis sicca]]
|-
| colspan="2" style="background: #DCDCDC; padding: 5px; text-align: center;" |Sarcoidosis
| style="background: #F5F5F5; padding: 5px;" |painless
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
|
|<nowiki>-</nowiki>
|<nowiki>-</nowiki>
|
|
|
|
|
|
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
! colspan="3" |Diseases
!Lymphadenopathy
! colspan="1" rowspan="1" |Fever
!Weight loss
!Night sweats
! colspan="1" rowspan="1" |Rash
!Other symptoms
!Immunochemistry
!Blood work
!Biopsy
Histopathology
!Pathogonomical
findings
|-
|-
| rowspan="6" |'''NEOPLASIA'''
| colspan="2" style="background: #DCDCDC; padding: 5px; text-align: center;" |Hodgkin's disease<ref>{{cite book|title=Scientific Style and Format: The CBE Manual for Authors, Editors, and Publishers|url=https://books.google.com/books?id=PoFJ-OhE63UC&pg=PA97|year=1994|publisher=Cambridge University Press|isbn=978-0-521-47154-1|pages=97–}}</ref><ref name="Lozano_2012">{{cite journal  |vauthors=Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, etal | title = Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. | journal = Lancet | volume = 380 | issue = 9859 | pages = 2095–128 | date = Dec 15, 2012 | oclc = 23245604 | doi = 10.1016/S0140-6736(12)61728-0 }}</ref><ref name="pmid15164877">{{cite journal| author=Shishodia S, Aggarwal BB| title=Nuclear factor-kappaB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer. | journal=Cancer Treat Res | year= 2004 | volume= 119 | issue=  | pages= 139-73 | pmid=15164877 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15164877  }}</ref><ref name="pmid8639794">{{cite journal| author=Bargou RC, Leng C, Krappmann D, Emmerich F, Mapara MY, Bommert K et al.| title=High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells. | journal=Blood | year= 1996 | volume= 87 | issue= 10 | pages= 4340-7 | pmid=8639794 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8639794  }}</ref>
| style="background: #F5F5F5; padding: 5px;" |painless
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |<nowiki/>
**Lactate dehydrogenase (LDH) may be increased.
**ESR elevated
**Serum creatinine elevated in nephrotic syndrome.
**Alkaline phosphatase (ALP) increased
**Hypercalcemia, hypernatremia, and hypoglycemia.
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
Fine-needle aspiration
*Mononucleate and binucleate Reed-Sternberg cells in a background of inflammatory cells
| style="background: #F5F5F5; padding: 5px;" |Reed-Sternberg cells on microscopic pathology.
|-
| colspan="2" style="background: #DCDCDC; padding: 5px; text-align: center;" |Chronic lymphocytic leukemia<ref name="pmid25461996">{{cite journal| author=Nabhan C, Rosen ST| title=Chronic lymphocytic leukemia: a clinical review. | journal=JAMA | year= 2014 | volume= 312 | issue= 21 | pages= 2265-76 | pmid=25461996 | doi=10.1001/jama.2014.14553 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25461996  }}</ref><ref name="pmid25908509">{{cite journal| author=Hallek M| title=Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment. | journal=Am J Hematol | year= 2015 | volume= 90 | issue= 5 | pages= 446-60 | pmid=25908509 | doi=10.1002/ajh.23979 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25908509  }}</ref><ref name="patho">Chronic Lymphocytic Leukemia. Libre Pathology (2015) http://librepathology.org/wiki/index.php/B_cell_small_lymphocytic_lymphoma/chronic_lymphocytic_leukemia Accessed on October, 12 2015</ref><ref name="pmid259085092">{{cite journal| author=Hallek M| title=Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment. | journal=Am J Hematol | year= 2015 | volume= 90 | issue= 5 | pages= 446-60 | pmid=25908509 | doi=10.1002/ajh.23979 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25908509  }}</ref>
| style="background: #F5F5F5; padding: 5px;" |Painless
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" |
*Recurrent [[bleeding]]
*[[Muscle wasting]]
*Generalized [[weakness]]
*Anorexia
*[[Abdominal pain]]
*Recurrent [[Infection|infections]]
| style="background: #F5F5F5; padding: 5px;" |
*Monoclonality of kappa and lambda producing [[B cell|B cells]]
*Presence of smudge cells
*Express [[CD19]], [[CD20]], [[CD23]], and [[CD5]] on the [[cell]] surface
| style="background: #F5F5F5; padding: 5px;" |
CBC
*Absolute [[lymphocytosis]] (>5000 cells/μl)
*Decreased [[hemoglobin]] concentration
*Decreased [[Platelet|platelets]] count
| style="background: #F5F5F5; padding: 5px;" |
*On [[microscopic]] [[histopathological]] analysis:
:*Small [[lymphoid]] [[cell]]s
:*Thin [[cytoplasmic]] border
:*Dense [[nucleus]]
:*Lack of [[nucleolus]]
:*Clumped [[chromatin]] aggregates
:*The presence of smudge cells
:*The presence of gumprecht [[nuclear]] shadows
| style="background: #F5F5F5; padding: 5px;" |
|-
| colspan="2" style="background: #DCDCDC; padding: 5px; text-align: center;" |Small cell carcinoma of the lung<ref name="Zakowski2003">{{cite journal|last1=Zakowski|first1=Maureen F.|title=Pathology of small cell carcinoma of the lung|journal=Seminars in Oncology|volume=30|issue=1|year=2003|pages=3–8|issn=00937754|doi=10.1053/sonc.2003.50015}}</ref><ref name="NCI">National Cancer Institute: PDQ® Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute.  Available at: http://www.cancer.gov/cancertopics/pdq/treatment/small-cell-lung/healthprofessional.</ref><ref>{{Cite journal
| author = [[Grace K. Dy]] & [[Alex A. Adjei]]
| title = Novel targets for lung cancer therapy: part I
| journal = [[Journal of clinical oncology : official journal of the American Society of Clinical Oncology]]
| volume = 20
| issue = 12
| pages = 2881–2894
| year = 2002
| month = June
| pmid = 12065566
}}</ref><ref>{{Cite journal
| author = [[K. Hibi]], [[T. Takahashi]], [[Y. Sekido]], [[R. Ueda]], [[T. Hida]], [[Y. Ariyoshi]], [[H. Takagi]] & [[T. Takahashi]]
| title = Coexpression of the stem cell factor and the c-kit genes in small-cell lung cancer
| journal = [[Oncogene]]
| volume = 6
| issue = 12
| pages = 2291–2296
| year = 1991
| month = December
| pmid = 1722571
}}</ref><ref>{{Cite journal
| author = [[Yuri Pekarsky]], [[Alexey Palamarchuk]], [[Kay Huebner]] & [[Carlo M. Croce]]
| title = FHIT as tumor suppressor: mechanisms and therapeutic opportunities
| journal = [[Cancer biology & therapy]]
| volume = 1
| issue = 3
| pages = 232–236
| year = 2002
| month = May-June
| pmid = 12432269
}}</ref>
| style="background: #F5F5F5; padding: 5px;" |painless
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" |-
| style="background: #F5F5F5; padding: 5px;" |
* [[Syndrome of inappropriate antidiuresis]] ([[SIADH]])
* Hypercalcemia
*[[Cough]] (most common symptom)
*[[Wheezing]]
*[[Dyspnea]]
*[[Hemoptysis]]
*[[Chest pain]]
| style="background: #F5F5F5; padding: 5px;" |
Nearly all SCLC are immunoreactive for
*[[keratin]],
*[[thyroid transcription factor 1]],
*[[Epithelial cells|epithelial]] membrane [[antigen]]
[[Neuroendocrine]] and [[neural]] [[differentiation]] result in the expression of molecules like
*[[Dopamine beta-hydroxylase|dopa-decarboxylase]],
*[[calcitonin]]
*[[neuron-specific enolase]],
*[[chromogranin A]],
*[[CD56]]
*[[gastrin]]-releasing [[peptide]]
*[[insulin-like growth factor 1]]
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* The tumor cells are small and round, but they can sometimes be ovoid or spindle shaped. They have a scanty[[cytoplasm]] with a high mitotic count and a hyperchromatic [[nuclei]].
| style="background: #F5F5F5; padding: 5px;" |
|-
| colspan="2" style="background: #DCDCDC; padding: 5px; text-align: center;" |Melanoma<ref name="pmid16822996">{{cite journal| author=Miller AJ, Mihm MC| title=Melanoma. | journal=N Engl J Med | year= 2006 | volume= 355 | issue= 1 | pages= 51-65 | pmid=16822996 | doi=10.1056/NEJMra052166 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16822996  }}</ref><ref name="book1">{{cite book|last=Schanderdorf D, Kochs C, Livingstone E |date=2013 |title=Handbook of Cutaneous Melanoma: A Guide to Diagnosis and Treatment |publisher=Springer }}</ref><ref name="book2">{{cite book|last=Mooi W, Krausz T|date=2007 |title=Pathology of Melanocytic Disorders 2nd Ed. |publisher=CRC Press}}</ref>
| style="background: #F5F5F5; padding: 5px;" |painless
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" |-
| style="background: #F5F5F5; padding: 5px;" |
*Rapid growth of an existing [[nevus]]
*[[Nevus|Bleeding nevus]]
*[[Nodule|Cutaneous nodules]]
*[[Hyperpigmentation|Hyper]]/[[Hypopigmented area|hypopigmented skin lesion]]
*[[Melanonychia]] (brown/blue nail discoloration)
*[[Skin ulcer|Non-healing skin ulcer]]
*[[Skin lesion|Painful skin lesion]]
*[[Pruritus]]
*[[Bone pain]]
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Positive for CD133+
* Positive for CD34+
| style="background: #F5F5F5; padding: 5px;" |
* An excisional biopsy (either elliptical, punch, or saucerization) of the thickest portion of the lesion with 1-3 mm margins.
| style="background: #F5F5F5; padding: 5px;" |Epidermal atrophy and flattening and prominent dermal invasion
|-
| colspan="2" style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Lymphomatoid granulomatosis]]
| style="background: #F5F5F5; padding: 5px;" |painless
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" |
*[[Cough]]
*[[Dyspnea]]
*[[Chest pain|Chest tightness]]
*[[Malaise]]
*[[Fatigue]]
*[[Headache|Headaches]]
*[[Seizure|Seizures]]
*[[Hemiparesis]]
*[[Ataxia]]
*[[Macule|Macules]]
*[[Papule|Papules]]
*[[Plaque|Plaques]]
*[[Nodule (medicine)|Subcutaneous nodules]]
*[[Nodule (medicine)|Larger ulcerated nodules]]
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" |
'''CBC'''
*[[Leukopenia]]
*[[Lymphocytopenia|Lymphopenia]]
*Low [[CD4]] count
*[[Leukocytosis]] is rare
*Elevated [[Hematocrit]]
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" |On chest CT scan, [[Halo sign]] is seen due to the angioinvasive nature of the disease
|-
| colspan="2" style="background: #DCDCDC; padding: 5px; text-align: center;" |Angioimmunoblastic lymphadenopathy
| style="background: #F5F5F5; padding: 5px;" |painless
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" |
*[[Edema]]
*Chest pain
*[[Abdominal pain]]
*[[Bone pain]]
*[[Fatigue]]
*[[Pale skin color]]
*[[Dark urine]]
*[[Chronic pain]] and swelling of the joints
| style="background: #F5F5F5; padding: 5px;" |
*Immunophenotyping
:*Positivity for [[CD2]], [[CD3]], [[CD4]], [[CD5]], [[CD10]], [[CD20]], and focal positivity for [[CXCL13]]
:*Negative for ALK1 and [[CD30]]
*Fluorescence in situ hybridization ([[FISH]])
| style="background: #F5F5F5; padding: 5px;" |
*[[Complete blood count]] (CBC)
:*[[Anemia]]
:*[[Eosinophilia]]
| style="background: #F5F5F5; padding: 5px;" |Lymph node or extranodal tissue biopsy is diagnostic of angioimmunoblastic T-cell lymphoma.
*Characteristic findings on gross pathology, aborization and proliferation of [[high endothelial venules]]
*On microscopic histopathological analysis, [[CD4]]+ [[T-cells]], [[CD8]]+ [[T-cells]], and polyclonal [[plasma cells]].
| style="background: #F5F5F5; padding: 5px;" |
*[[Epstein–Barr virus]] (EBV) has been found in both reactive B-cells  and the neoplastic T-cells.
*[[Trisomy]] 3, trisomy 5, and +X are the most frequent chromosomal abnormalities found in cases.
|-
| rowspan="3" |'''NEOPLASIA'''
| colspan="2" style="background: #DCDCDC; padding: 5px; text-align: center;" |Giant lymph node hyperplasia (Castleman disease)
| style="background: #F5F5F5; padding: 5px;" |painless
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" |
*[[Anemia]]
*[[Loss of appetite]]
*[[Cough]]
*Chest discomfort
*[[Fatigue]]
*[[Weakness]]
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" |
*Complete blood count and differential count - [[low white blood cell counts]], which may to be due to the overproduction of [[interleukin 6]].
*[[Erythrocyte sedimentation rate]] - elevated in 80% cases.
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" |
* Hypersecretion of the cytokine [[Interleukin 6|IL-6]].
|}
|}


==References==
==References==
{{reflist|2}}
{{reflist|2}}

Latest revision as of 17:32, 14 January 2019


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2]

Tables

Diagnosis Lab findings

References

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