SVIL: Difference between revisions
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==References== | ==References== | ||
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==Further reading== | ==Further reading== | ||
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Revision as of 14:48, 6 September 2012
| Supervillin | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | SVIL ; DKFZp686A17191 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 25090 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SVIL 202565 s at tn.png | |||||||||||
| File:PBB GE SVIL 202566 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Supervillin, also known as SVIL, is a human gene.[1]
This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. Its function may include recruitment of actin and other cytoskeletal proteins into specialized structures at the plasma membrane and in the nuclei of growing cells. Two transcript variants encoding different isoforms of supervillin have been described.[1]
References
Further reading
- Pestonjamasp KN, Pope RK, Wulfkuhle JD, Luna EJ (1997). "Supervillin (p205): A novel membrane-associated, F-actin-binding protein in the villin/gelsolin superfamily". J. Cell Biol. 139 (5): 1255–69. PMID 9382871.
- Pope RK, Pestonjamasp KN, Smith KP; et al. (1998). "Cloning, characterization, and chromosomal localization of human supervillin (SVIL)". Genomics. 52 (3): 342–51. PMID 9867483.
- Wulfkuhle JD, Donina IE, Stark NH; et al. (1999). "Domain analysis of supervillin, an F-actin bundling plasma membrane protein with functional nuclear localization signals". J. Cell. Sci. 112 ( Pt 13): 2125–36. PMID 10362542.
- Kim M, Jiang LH, Wilson HL; et al. (2002). "Proteomic and functional evidence for a P2X7 receptor signalling complex". EMBO J. 20 (22): 6347–58. doi:10.1093/emboj/20.22.6347. PMID 11707406.
- Ting HJ, Yeh S, Nishimura K, Chang C (2002). "Supervillin associates with androgen receptor and modulates its transcriptional activity". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 661–6. doi:10.1073/pnas.022469899. PMID 11792840.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Oh SW, Pope RK, Smith KP; et al. (2004). "Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton". J. Cell. Sci. 116 (Pt 11): 2261–75. doi:10.1242/jcs.00422. PMID 12711699.
- Chen Y, Takizawa N, Crowley JL; et al. (2003). "F-actin and myosin II binding domains in supervillin". J. Biol. Chem. 278 (46): 46094–106. doi:10.1074/jbc.M305311200. PMID 12917436.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
- Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
- Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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