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{{Underlinked|date=March 2014}}
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{{Infobox_gene}}
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'''Stanniocalcin-2''' is a [[protein]] that in humans is encoded by the ''STC2'' [[gene]].<ref name="pmid9723890">{{cite journal | vauthors = Chang AC, Reddel RR | title = Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2 | journal = Mol Cell Endocrinol | volume = 141 | issue = 1–2 | pages = 95–9 |date=Nov 1998 | pmid = 9723890 | pmc =  | doi =10.1016/S0303-7207(98)00097-5  }}</ref><ref name="pmid9753616">{{cite journal | vauthors = Ishibashi K, Miyamoto K, Taketani Y, Morita K, Takeda E, Sasaki S, Imai M | title = Molecular cloning of a second human stanniocalcin homologue (STC2) | journal = Biochem Biophys Res Commun | volume = 250 | issue = 2 | pages = 252–8 |date=Nov 1998 | pmid = 9753616 | pmc = | doi = 10.1006/bbrc.1998.9300 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STC2 stanniocalcin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8614| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Stanniocalcin 2
| HGNCid = 11374
| Symbol = STC2
| AltSymbols =; STC-2; STCRP
| OMIM = 603665
| ECnumber = 
| Homologene = 2753
| MGIid = 1316731
| GeneAtlas_image1 = PBB_GE_STC2_203439_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_STC2_203438_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007584 |text = response to nutrient}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8614
    | Hs_Ensembl = ENSG00000113739
    | Hs_RefseqProtein = NP_003705
    | Hs_RefseqmRNA = NM_003714
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 172674332
    | Hs_GenLoc_end = 172689112
    | Hs_Uniprot = O76061
    | Mm_EntrezGene = 20856
    | Mm_Ensembl = ENSMUSG00000020303
    | Mm_RefseqmRNA = NM_011491
    | Mm_RefseqProtein = NP_035621
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 31259441
    | Mm_GenLoc_end = 31270061
    | Mm_Uniprot = Q5SS12
  }}
}}
'''Stanniocalcin 2''', also known as '''STC2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: STC2 stanniocalcin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8614| accessdate = }}</ref>
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/[[phosphate homeostasis]]. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.<ref name="entrez">{{cite web | title = Entrez Gene: STC2 stanniocalcin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8614| accessdate = }}</ref>
| summary_text = This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.<ref name="entrez"/>
}}
}}
Stanniocalcin 2 may suppress P<sub>i</sub> cotransport.<ref name=Murer>{{ cite journal |author=Murer H, Hernando N, Forster I, Biber J |title=Proximal tubular phosphate reabsorption: molecular mechanisms |journal=Physiol Rev. |year=2000 |month=Oct |volume=80 |issue=4 |pages=1373-409 |pmid=11015617 }}</ref>


==References==
==References==
{{reflist}}
{{reflist}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Chang AC, Reddel RR |title=Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2. |journal=Mol. Cell. Endocrinol. |volume=141 |issue= 1-2 |pages= 95-9 |year= 1998 |pmid= 9723890 |doi=  }}
*{{cite journal  | vauthors=DiMattia GE, Varghese R, Wagner GF |title=Molecular cloning and characterization of stanniocalcin-related protein |journal=Mol. Cell. Endocrinol. |volume=146 |issue= 1–2 |pages= 137–40 |year= 1999 |pmid= 10022771 |doi=10.1016/S0303-7207(98)00163-4 }}
*{{cite journal  | author=Ishibashi K, Miyamoto K, Taketani Y, ''et al.'' |title=Molecular cloning of a second human stanniocalcin homologue (STC2). |journal=Biochem. Biophys. Res. Commun. |volume=250 |issue= 2 |pages= 252-8 |year= 1998 |pmid= 9753616 |doi= 10.1006/bbrc.1998.9300 }}
*{{cite journal   |vauthors=Moore EE, Kuestner RE, Conklin DC, etal |title=Stanniocalcin 2: characterization of the protein and its localization to human pancreatic alpha cells |journal=Horm. Metab. Res. |volume=31 |issue= 7 |pages= 406–14 |year= 1999 |pmid= 10450831 |doi=10.1055/s-2007-978764 }}
*{{cite journal  | author=DiMattia GE, Varghese R, Wagner GF |title=Molecular cloning and characterization of stanniocalcin-related protein. |journal=Mol. Cell. Endocrinol. |volume=146 |issue= 1-2 |pages= 137-40 |year= 1999 |pmid= 10022771 |doi=  }}
*{{cite journal   |vauthors=Jellinek DA, Chang AC, Larsen MR, etal |title=Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells |journal=Biochem. J. |volume=350 Pt 2 |issue=  |pages= 453–61 |year= 2001 |pmid= 10947959 |doi= 10.1042/0264-6021:3500453| pmc=1221272 }}
*{{cite journal | author=Moore EE, Kuestner RE, Conklin DC, ''et al.'' |title=Stanniocalcin 2: characterization of the protein and its localization to human pancreatic alpha cells. |journal=Horm. Metab. Res. |volume=31 |issue= 7 |pages= 406-14 |year= 1999 |pmid= 10450831 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Jellinek DA, Chang AC, Larsen MR, ''et al.'' |title=Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells. |journal=Biochem. J. |volume=350 Pt 2 |issue=  |pages= 453-61 |year= 2001 |pmid= 10947959 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gagliardi AD, Kuo EY, Raulic S, etal |title=Human stanniocalcin-2 exhibits potent growth-suppressive properties in transgenic mice independently of growth hormone and IGFs |journal=Am. J. Physiol. Endocrinol. Metab. |volume=288 |issue= 1 |pages= E92–105 |year= 2005 |pmid= 15367391 |doi= 10.1152/ajpendo.00268.2004 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | vauthors=Luo CW, Pisarska MD, Hsueh AJ |title=Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary |journal=Endocrinology |volume=146 |issue= 1 |pages= 469–76 |year= 2005 |pmid= 15486227 |doi= 10.1210/en.2004-1197 }}
*{{cite journal | author=Gagliardi AD, Kuo EY, Raulic S, ''et al.'' |title=Human stanniocalcin-2 exhibits potent growth-suppressive properties in transgenic mice independently of growth hormone and IGFs. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=288 |issue= 1 |pages= E92-105 |year= 2005 |pmid= 15367391 |doi= 10.1152/ajpendo.00268.2004 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Luo CW, Pisarska MD, Hsueh AJ |title=Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary. |journal=Endocrinology |volume=146 |issue= 1 |pages= 469-76 |year= 2005 |pmid= 15486227 |doi= 10.1210/en.2004-1197 }}
*{{cite journal   |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal   |vauthors=Esseghir S, Kennedy A, Seedhar P, etal |title=Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins |journal=Clin. Cancer Res. |volume=13 |issue= 11 |pages= 3164–73 |year= 2007 |pmid= 17545519 |doi= 10.1158/1078-0432.CCR-07-0224 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal   |vauthors=Ichikawa T, Horie-Inoue K, Ikeda K, etal |title=Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells |journal=J. Mol. Endocrinol. |volume=39 |issue= 4 |pages= 239–47 |year= 2007 |pmid= 17909264 |doi= 10.1677/JME-07-0048 }}
*{{cite journal | author=Esseghir S, Kennedy A, Seedhar P, ''et al.'' |title=Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins. |journal=Clin. Cancer Res. |volume=13 |issue= 11 |pages= 3164-73 |year= 2007 |pmid= 17545519 |doi= 10.1158/1078-0432.CCR-07-0224 }}
*{{cite journal | author=Ichikawa T, Horie-Inoue K, Ikeda K, ''et al.'' |title=Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells. |journal=J. Mol. Endocrinol. |volume=39 |issue= 4 |pages= 239-47 |year= 2007 |pmid= 17909264 |doi= 10.1677/JME-07-0048 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 07:10, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Stanniocalcin-2 is a protein that in humans is encoded by the STC2 gene.[1][2][3]

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.[3]

References

  1. ↑ Chang AC, Reddel RR (Nov 1998). "Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2". Mol Cell Endocrinol. 141 (1–2): 95–9. doi:10.1016/S0303-7207(98)00097-5. PMID 9723890.
  2. ↑ Ishibashi K, Miyamoto K, Taketani Y, Morita K, Takeda E, Sasaki S, Imai M (Nov 1998). "Molecular cloning of a second human stanniocalcin homologue (STC2)". Biochem Biophys Res Commun. 250 (2): 252–8. doi:10.1006/bbrc.1998.9300. PMID 9753616.
  3. ↑ 3.0 3.1 "Entrez Gene: STC2 stanniocalcin 2".

Further reading



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