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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Stanniocalcin-1''' is a [[glycoprotein]], a homologue of a hormone [[stanniocalcin]], first discovered in bony fishes. In humans it is encoded by the ''STC1'' [[gene]].<ref name="pmid9480753">{{cite journal | vauthors = Chang AC, Jeffrey KJ, Tokutake Y, Shimamoto A, Neumann AA, Dunham MA, Cha J, Sugawara M, Furuichi Y, Reddel RR | title = Human stanniocalcin (STC): genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats | journal = Genomics | volume = 47 | issue = 3 | pages = 393–8 | date = Feb 1998 | pmid = 9480753 | pmc = | doi = 10.1006/geno.1997.5120 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STC1 stanniocalcin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6781| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Stanniocalcin 1
| HGNCid = 11373
| Symbol = STC1
| AltSymbols =; STC
| OMIM = 601185
| ECnumber = 
| Homologene = 2374
| MGIid = 109131
| GeneAtlas_image1 = PBB_GE_STC1_204595_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_STC1_204596_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_STC1_204597_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007584 |text = response to nutrient}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6781
    | Hs_Ensembl = ENSG00000159167
    | Hs_RefseqProtein = NP_003146
    | Hs_RefseqmRNA = NM_003155
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 23755373
    | Hs_GenLoc_end = 23768265
    | Hs_Uniprot = P52823
    | Mm_EntrezGene = 20855
    | Mm_Ensembl = ENSMUSG00000014813
    | Mm_RefseqmRNA = NM_009285
    | Mm_RefseqProtein = NP_033311
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 67982603
    | Mm_GenLoc_end = 67993272
    | Mm_Uniprot = Q3TSM0
  }}
}}
'''Stanniocalcin 1''', also known as '''STC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: STC1 stanniocalcin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6781| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. Human Stanniocalcin-1 is a putative molecular biomarker of leukemic microenvironment and the only molecular function known up to date is a SUMO E3 ligase activity in the SUMOylation cycle. STC1 interacts with lots of proteins in the [[cytoplasm]], [[mitochondria]], endoplasmatic [[reticulum]] and dot-like fashion in the nucleus. The N-terminal region of STC1 is the function region which is responsible to establish the interaction with its partners, including SUMO1.<ref>{{cite journal | vauthors = dos Santos MT, Trindade DM, Gonçalves Kde A, Bressan GC, Anastassopoulos F, Yunes JA, Kobarg J | title = Human stanniocalcin-1 interacts with nuclear and cytoplasmic proteins and acts as a SUMO E3 ligase | journal = Molecular bioSystems | volume = 7 | issue = 1 | pages = 180–93 | date = Jan 2011 | pmid = 21042649 | doi = 10.1039/c0mb00088d }}</ref> Low resolution studies shows that STC1 is an anti-parallel homodimer in solution and the cystein 202 is responsible for the dimerization of this protein. All the 5 dissulfide bonds of human STC1 are conserved and has the same profile of fish STC.<ref>{{cite journal | vauthors = Trindade DM, Silva JC, Navarro MS, Torriani IC, Kobarg J | title = Low-resolution structural studies of human Stanniocalcin-1 | journal = BMC Structural Biology | volume = 9 | pages = 57 | date = Aug 27, 2009 | pmid = 19712479 | pmc = 2744999 | doi = 10.1186/1472-6807-9-57 }}</ref> The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved [[cysteine]] residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate [[homeostasis]]. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, [[dwarfism]], and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/[[phosphate homeostasis]]. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.<ref name="entrez">{{cite web | title = Entrez Gene: STC1 stanniocalcin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6781| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Chang AC, Jellinek DA, Reddel RR | title = Mammalian stanniocalcins and cancer | journal = Endocrine-Related Cancer | volume = 10 | issue = 3 | pages = 359–73 | date = Sep 2003 | pmid = 14503913 | doi = 10.1677/erc.0.0100359 }}
| citations =
* {{cite journal | vauthors = Liang P, Averboukh L, Keyomarsi K, Sager R, Pardee AB | title = Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells | journal = Cancer Research | volume = 52 | issue = 24 | pages = 6966–8 | date = Dec 1992 | pmid = 1458489 | doi =  }}
*{{cite journal | author=Chang AC, Jellinek DA, Reddel RR |title=Mammalian stanniocalcins and cancer. |journal=Endocr. Relat. Cancer |volume=10 |issue= 3 |pages= 359-73 |year= 2004 |pmid= 14503913 |doi= }}
* {{cite journal | vauthors = Chang AC, Janosi J, Hulsbeek M, de Jong D, Jeffrey KJ, Noble JR, Reddel RR | title = A novel human cDNA highly homologous to the fish hormone stanniocalcin | journal = Molecular and Cellular Endocrinology | volume = 112 | issue = 2 | pages = 241–7 | date = Aug 1995 | pmid = 7489828 | doi = 10.1016/0303-7207(95)03601-3 }}
*{{cite journal | author=Liang P, Averboukh L, Keyomarsi K, ''et al.'' |title=Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells. |journal=Cancer Res. |volume=52 |issue= 24 |pages= 6966-8 |year= 1993 |pmid= 1458489 |doi=  }}
* {{cite journal | vauthors = Wagner GF, Guiraudon CC, Milliken C, Copp DH | title = Immunological and biological evidence for a stanniocalcin-like hormone in human kidney | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 6 | pages = 1871–5 | date = Mar 1995 | pmid = 7892193 | pmc = 42384 | doi = 10.1073/pnas.92.6.1871 }}
*{{cite journal | author=Chang AC, Janosi J, Hulsbeek M, ''et al.'' |title=A novel human cDNA highly homologous to the fish hormone stanniocalcin. |journal=Mol. Cell. Endocrinol. |volume=112 |issue= 2 |pages= 241-7 |year= 1996 |pmid= 7489828 |doi= }}
* {{cite journal | vauthors = Olsen HS, Cepeda MA, Zhang QQ, Rosen CA, Vozzolo BL, Wagner GF | title = Human stanniocalcin: a possible hormonal regulator of mineral metabolism | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 5 | pages = 1792–6 | date = Mar 1996 | pmid = 8700837 | pmc = 39860 | doi = 10.1073/pnas.93.5.1792 }}
*{{cite journal | author=Wagner GF, Guiraudon CC, Milliken C, Copp DH |title=Immunological and biological evidence for a stanniocalcin-like hormone in human kidney. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 6 |pages= 1871-5 |year= 1995 |pmid= 7892193 |doi= }}
* {{cite journal | vauthors = Zhang KZ, Westberg JA, Paetau A, von Boguslawsky K, Lindsberg P, Erlander M, Guo H, Su J, Olsen HS, Andersson LC | title = High expression of stanniocalcin in differentiated brain neurons | journal = The American Journal of Pathology | volume = 153 | issue = 2 | pages = 439–45 | date = Aug 1998 | pmid = 9708804 | pmc = 1852984 | doi = 10.1016/S0002-9440(10)65587-3 }}
*{{cite journal | author=Olsen HS, Cepeda MA, Zhang QQ, ''et al.'' |title=Human stanniocalcin: a possible hormonal regulator of mineral metabolism. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 5 |pages= 1792-6 |year= 1996 |pmid= 8700837 |doi= }}
* {{cite journal | vauthors = Varghese R, Wong CK, Deol H, Wagner GF, DiMattia GE | title = Comparative analysis of mammalian stanniocalcin genes | journal = Endocrinology | volume = 139 | issue = 11 | pages = 4714–25 | date = Nov 1998 | pmid = 9794484 | doi = 10.1210/en.139.11.4714 }}
*{{cite journal  | author=Chang AC, Jeffrey KJ, Tokutake Y, ''et al.'' |title=Human stanniocalcin (STC): genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats. |journal=Genomics |volume=47 |issue= 3 |pages= 393-8 |year= 1998 |pmid= 9480753 |doi= 10.1006/geno.1997.5120 }}
* {{cite journal | vauthors = ((Zhang Kz)), Lindsberg PJ, Tatlisumak T, Kaste M, Olsen HS, Andersson LC | title = Stanniocalcin: A molecular guard of neurons during cerebral ischemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 7 | pages = 3637–42 | date = Mar 2000 | pmid = 10725397 | pmc = 16292 | doi = 10.1073/pnas.070045897 }}
*{{cite journal | author=Zhang KZ, Westberg JA, Paetau A, ''et al.'' |title=High expression of stanniocalcin in differentiated brain neurons. |journal=Am. J. Pathol. |volume=153 |issue= 2 |pages= 439-45 |year= 1998 |pmid= 9708804 |doi= }}
* {{cite journal | vauthors = Jellinek DA, Chang AC, Larsen MR, Wang X, Robinson PJ, Reddel RR | title = Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells | journal = The Biochemical Journal | volume = 350 Pt 2 | issue = 2 | pages = 453–61 | date = Sep 2000 | pmid = 10947959 | pmc = 1221272 | doi = 10.1042/0264-6021:3500453 }}
*{{cite journal | author=Varghese R, Wong CK, Deol H, ''et al.'' |title=Comparative analysis of mammalian stanniocalcin genes. |journal=Endocrinology |volume=139 |issue= 11 |pages= 4714-25 |year= 1998 |pmid= 9794484 |doi= }}
* {{cite journal | vauthors = Varghese R, Gagliardi AD, Bialek PE, Yee SP, Wagner GF, Dimattia GE | title = Overexpression of human stanniocalcin affects growth and reproduction in transgenic mice | journal = Endocrinology | volume = 143 | issue = 3 | pages = 868–76 | date = Mar 2002 | pmid = 11861508 | doi = 10.1210/en.143.3.868 }}
*{{cite journal | author=Zhang K, Lindsberg PJ, Tatlisumak T, ''et al.'' |title=Stanniocalcin: A molecular guard of neurons during cerebral ischemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3637-42 |year= 2000 |pmid= 10725397 |doi= 10.1073/pnas.070045897 }}
* {{cite journal | vauthors = McCudden CR, James KA, Hasilo C, Wagner GF | title = Characterization of mammalian stanniocalcin receptors. Mitochondrial targeting of ligand and receptor for regulation of cellular metabolism | journal = The Journal of Biological Chemistry | volume = 277 | issue = 47 | pages = 45249–58 | date = Nov 2002 | pmid = 12223480 | doi = 10.1074/jbc.M205954200 }}
*{{cite journal | author=Jellinek DA, Chang AC, Larsen MR, ''et al.'' |title=Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells. |journal=Biochem. J. |volume=350 Pt 2 |issue= |pages= 453-61 |year= 2001 |pmid= 10947959 |doi= }}
* {{cite journal | vauthors = Serlachius M, Alitalo R, Olsen HS, Andersson LC | title = Expression of stanniocalcin-1 in megakaryocytes and platelets | journal = British Journal of Haematology | volume = 119 | issue = 2 | pages = 359–63 | date = Nov 2002 | pmid = 12406069 | doi = 10.1046/j.1365-2141.2002.03916.x }}
*{{cite journal | author=Varghese R, Gagliardi AD, Bialek PE, ''et al.'' |title=Overexpression of human stanniocalcin affects growth and reproduction in transgenic mice. |journal=Endocrinology |volume=143 |issue= 3 |pages= 868-76 |year= 2002 |pmid= 11861508 |doi= }}
* {{cite journal | vauthors = Sheikh-Hamad D, Bick R, Wu GY, Christensen BM, Razeghi P, Poindexter B, Taegtmeyer H, Wamsley A, Padda R, Entman M, Nielsen S, Youker K | title = Stanniocalcin-1 is a naturally occurring L-channel inhibitor in cardiomyocytes: relevance to human heart failure | journal = American Journal of Physiology. Heart and Circulatory Physiology | volume = 285 | issue = 1 | pages = H442-8 | date = Jul 2003 | pmid = 12663264 | doi = 10.1152/ajpheart.01071.2002 }}
*{{cite journal | author=McCudden CR, James KA, Hasilo C, Wagner GF |title=Characterization of mammalian stanniocalcin receptors. Mitochondrial targeting of ligand and receptor for regulation of cellular metabolism. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45249-58 |year= 2003 |pmid= 12223480 |doi= 10.1074/jbc.M205954200 }}
* {{cite journal | vauthors = Zlot C, Ingle G, Hongo J, Yang S, Sheng Z, Schwall R, Paoni N, Wang F, Peale FV, Gerritsen ME | title = Stanniocalcin 1 is an autocrine modulator of endothelial angiogenic responses to hepatocyte growth factor | journal = The Journal of Biological Chemistry | volume = 278 | issue = 48 | pages = 47654–9 | date = Nov 2003 | pmid = 14500721 | doi = 10.1074/jbc.M301353200 }}
*{{cite journal | author=Serlachius M, Alitalo R, Olsen HS, Andersson LC |title=Expression of stanniocalcin-1 in megakaryocytes and platelets. |journal=Br. J. Haematol. |volume=119 |issue= 2 |pages= 359-63 |year= 2002 |pmid= 12406069 |doi= }}
* {{cite journal | vauthors = McCudden CR, Majewski A, Chakrabarti S, Wagner GF | title = Co-localization of stanniocalcin-1 ligand and receptor in human breast carcinomas | journal = Molecular and Cellular Endocrinology | volume = 213 | issue = 2 | pages = 167–72 | date = Jan 2004 | pmid = 15062564 | doi = 10.1016/j.mce.2003.10.042 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Luo CW, Kawamura K, Klein C, Hsueh AJ | title = Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors | journal = Molecular Endocrinology | volume = 18 | issue = 8 | pages = 2085–96 | date = Aug 2004 | pmid = 15131261 | doi = 10.1210/me.2004-0066 }}
*{{cite journal | author=Sheikh-Hamad D, Bick R, Wu GY, ''et al.'' |title=Stanniocalcin-1 is a naturally occurring L-channel inhibitor in cardiomyocytes: relevance to human heart failure. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=285 |issue= 1 |pages= H442-8 |year= 2003 |pmid= 12663264 |doi= 10.1152/ajpheart.01071.2002 }}
* {{cite journal | vauthors = Serlachius M, Andersson LC | title = Upregulated expression of stanniocalcin-1 during adipogenesis | journal = Experimental Cell Research | volume = 296 | issue = 2 | pages = 256–64 | date = Jun 2004 | pmid = 15149855 | doi = 10.1016/j.yexcr.2004.02.016 }}
*{{cite journal | author=Zlot C, Ingle G, Hongo J, ''et al.'' |title=Stanniocalcin 1 is an autocrine modulator of endothelial angiogenic responses to hepatocyte growth factor. |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 47654-9 |year= 2004 |pmid= 14500721 |doi= 10.1074/jbc.M301353200 }}
*{{cite journal | author=McCudden CR, Majewski A, Chakrabarti S, Wagner GF |title=Co-localization of stanniocalcin-1 ligand and receptor in human breast carcinomas. |journal=Mol. Cell. Endocrinol. |volume=213 |issue= 2 |pages= 167-72 |year= 2004 |pmid= 15062564 |doi= 10.1016/j.mce.2003.10.042 }}
*{{cite journal | author=Luo CW, Kawamura K, Klein C, Hsueh AJ |title=Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors. |journal=Mol. Endocrinol. |volume=18 |issue= 8 |pages= 2085-96 |year= 2005 |pmid= 15131261 |doi= 10.1210/me.2004-0066 }}
*{{cite journal | author=Serlachius M, Andersson LC |title=Upregulated expression of stanniocalcin-1 during adipogenesis. |journal=Exp. Cell Res. |volume=296 |issue= 2 |pages= 256-64 |year= 2004 |pmid= 15149855 |doi= 10.1016/j.yexcr.2004.02.016 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 07:10, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Stanniocalcin-1 is a glycoprotein, a homologue of a hormone stanniocalcin, first discovered in bony fishes. In humans it is encoded by the STC1 gene.[1][2]

Function

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. Human Stanniocalcin-1 is a putative molecular biomarker of leukemic microenvironment and the only molecular function known up to date is a SUMO E3 ligase activity in the SUMOylation cycle. STC1 interacts with lots of proteins in the cytoplasm, mitochondria, endoplasmatic reticulum and dot-like fashion in the nucleus. The N-terminal region of STC1 is the function region which is responsible to establish the interaction with its partners, including SUMO1.[3] Low resolution studies shows that STC1 is an anti-parallel homodimer in solution and the cystein 202 is responsible for the dimerization of this protein. All the 5 dissulfide bonds of human STC1 are conserved and has the same profile of fish STC.[4] The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.[2]

References

  1. ↑ Chang AC, Jeffrey KJ, Tokutake Y, Shimamoto A, Neumann AA, Dunham MA, Cha J, Sugawara M, Furuichi Y, Reddel RR (Feb 1998). "Human stanniocalcin (STC): genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats". Genomics. 47 (3): 393–8. doi:10.1006/geno.1997.5120. PMID 9480753.
  2. ↑ 2.0 2.1 "Entrez Gene: STC1 stanniocalcin 1".
  3. ↑ dos Santos MT, Trindade DM, Gonçalves Kde A, Bressan GC, Anastassopoulos F, Yunes JA, Kobarg J (Jan 2011). "Human stanniocalcin-1 interacts with nuclear and cytoplasmic proteins and acts as a SUMO E3 ligase". Molecular bioSystems. 7 (1): 180–93. doi:10.1039/c0mb00088d. PMID 21042649.
  4. ↑ Trindade DM, Silva JC, Navarro MS, Torriani IC, Kobarg J (Aug 27, 2009). "Low-resolution structural studies of human Stanniocalcin-1". BMC Structural Biology. 9: 57. doi:10.1186/1472-6807-9-57. PMC 2744999. PMID 19712479.

Further reading


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