SIX1

Sine oculis homeobox homolog 1 (Drosophila)
Identifiers
Symbols	SIX1 ; BOS3; DFNA23; TIP39
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4360
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SIX1 205817 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Sine oculis homeobox homolog 1 (Drosophila), also known as SIX1, is a human gene.

The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the developing visual system of the fly. Members of the SIX gene family encode proteins that are characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which may be involved both in determining DNA-binding specificity and in mediating protein-protein interactions. Genes in the SIX family have been shown to play roles in vertebrate and insect development or have been implicated in maintenance of the differentiated state of tissues.[supplied by OMIM]

Further reading

• Oliver G, Wehr R, Jenkins NA; et al. (1995). "Homeobox genes and connective tissue patterning". Development. 121 (3): 693–705. PMID 7720577.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boucher CA, Carey N, Edwards YH; et al. (1996). "Cloning of the human SIX1 gene and its assignment to chromosome 14". Genomics. 33 (1): 140–2. doi:10.1006/geno.1996.0172. PMID 8617500.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ford HL, Kabingu EN, Bump EA; et al. (1998). "Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesis". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12608–13. PMID 9770533.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Salam AA, Häfner FM, Linder TE; et al. (2001). "A novel locus (DFNA23) for prelingual autosomal dominant nonsyndromic hearing loss maps to 14q21-q22 in a Swiss German kindred". Am. J. Hum. Genet. 66 (6): 1984–8. PMID 10777717.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ford HL, Landesman-Bollag E, Dacwag CS; et al. (2000). "Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein". J. Biol. Chem. 275 (29): 22245–54. doi:10.1074/jbc.M002446200. PMID 10801845.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fan X, Brass LF, Poncz M; et al. (2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. 275 (41): 32129–34. doi:10.1074/jbc.M004577200. PMID 10906137.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Buller C, Xu X, Marquis V; et al. (2002). "Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome". Hum. Mol. Genet. 10 (24): 2775–81. PMID 11734542.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li CM, Guo M, Borczuk A; et al. (2002). "Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition". Am. J. Pathol. 160 (6): 2181–90. PMID 12057921.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ikeda K, Watanabe Y, Ohto H, Kawakami K (2002). "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein". Mol. Cell. Biol. 22 (19): 6759–66. PMID 12215533.CS1 maint: Multiple names: authors list (link)
• López-Ríos J, Tessmar K, Loosli F; et al. (2003). "Six3 and Six6 activity is modulated by members of the groucho family". Development. 130 (1): 185–95. PMID 12441302.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ruf RG, Berkman J, Wolf MT; et al. (2003). "A gene locus for branchio-otic syndrome maps to chromosome 14q21.3-q24.3". J. Med. Genet. 40 (7): 515–9. PMID 12843324.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zheng W, Huang L, Wei ZB; et al. (2003). "The role of Six1 in mammalian auditory system development". Development. 130 (17): 3989–4000. PMID 12874121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li X, Oghi KA, Zhang J; et al. (2003). "Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis". Nature. 426 (6964): 247–54. doi:10.1038/nature02083. PMID 14628042.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Coletta RD, Christensen K, Reichenberger KJ; et al. (2004). "The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1". Proc. Natl. Acad. Sci. U.S.A. 101 (17): 6478–83. doi:10.1073/pnas.0401139101. PMID 15123840.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ruf RG, Xu PX, Silvius D; et al. (2004). "SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes". Proc. Natl. Acad. Sci. U.S.A. 101 (21): 8090–5. doi:10.1073/pnas.0308475101. PMID 15141091.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grifone R, Laclef C, Spitz F; et al. (2004). "Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype". Mol. Cell. Biol. 24 (14): 6253–67. doi:10.1128/MCB.24.14.6253-6267.2004. PMID 15226428.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ito T, Noguchi Y, Yashima T, Kitamura K (2006). "SIX1 mutation associated with enlargement of the vestibular aqueduct in a patient with branchio-oto syndrome". Laryngoscope. 116 (5): 796–9. doi:10.1097/01.mlg.0000209096.40400.96. PMID 16652090.CS1 maint: Multiple names: authors list (link)