Renal amyloidosis other diagnostic studies
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Renal amyloidosis Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
Other Diagnostic Studies
Kidney biopsy
- Kidney biopsy can represent amyloid deposition as vascular, tubulo-interstitial and/or glomerular deposits.[1]
- In evaluation of kidney biopsy specimens, types of amyloidogenic proteins can be discovered.[2]
Congo red staining
- All types of amyloidogenic proteins show affinity for Congo red dye, which demonstrates as:[3]
- Orange-red appearance by normal light microscopy
- Apple-green birefringence upon polarized light
References
- ↑ von Hutten H, Mihatsch M, Lobeck H, Rudolph B, Eriksson M, Röcken C (August 2009). "Prevalence and origin of amyloid in kidney biopsies". Am. J. Surg. Pathol. 33 (8): 1198–205. doi:10.1097/PAS.0b013e3181abdfa7. PMID 19561448.
- ↑ Khalighi MA, Dean Wallace W, Palma-Diaz MF (April 2014). "Amyloid nephropathy". Clin Kidney J. 7 (2): 97–106. doi:10.1093/ckj/sfu021. PMC 4377792. PMID 25852856.
- ↑ Khalighi MA, Dean Wallace W, Palma-Diaz MF (April 2014). "Amyloid nephropathy". Clin Kidney J. 7 (2): 97–106. doi:10.1093/ckj/sfu021. PMC 4377792. PMID 25852856.