Renal amyloidosis natural history, complications and prognosis: Difference between revisions

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==Overview==
==Overview==
If left untreated, renal amyoidosis may progress into end stage renal disease. Common complications include chronic renal failure and nephrotic syndrome. After a few years, renal amyloidosis eventually leads to end stage renal disease and it may be accelerated by some factors such as steroid administration, renal vein thrombos, iInfections and surgery.


==Natural History, Complications, and Prognosis==
==Natural History, Complications, and Prognosis==


===Natural History===
===Natural History===
*The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.  
If renal amyloidosis left untreated it usually manifests as nephrotic range proteinuria and then progresses to acute kidney injury and then end stage renal disease.<ref name="pmid27840752">{{cite journal |vauthors=Lohani S, Schuiteman E, Garg L, Yadav D, Zarouk S |title=Apolipoprotein C-II Deposition Amyloidosis: A Potential Misdiagnosis as Light Chain Amyloidosis |journal=Case Rep Nephrol |volume=2016 |issue= |pages=8690642 |date=2016 |pmid=27840752 |pmc=5093243 |doi=10.1155/2016/8690642 |url=}}</ref>
*The symptoms of (disease name) typically develop ___ years after exposure to ___.
*If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].


===Complications===
===Complications===
*Common complications of renal amyloidosis include:<ref name="pmid21360109">{{cite journal |vauthors=Bilginer Y, Akpolat T, Ozen S |title=Renal amyloidosis in children |journal=Pediatr. Nephrol. |volume=26 |issue=8 |pages=1215–27 |date=August 2011 |pmid=21360109 |pmc=3119800 |doi=10.1007/s00467-011-1797-x |url=}}</ref>
Common complications of renal amyloidosis include:<ref name="pmid21360109">{{cite journal |vauthors=Bilginer Y, Akpolat T, Ozen S |title=Renal amyloidosis in children |journal=Pediatr. Nephrol. |volume=26 |issue=8 |pages=1215–27 |date=August 2011 |pmid=21360109 |pmc=3119800 |doi=10.1007/s00467-011-1797-x |url=}}</ref><ref name="pmid27942184">{{cite journal |vauthors=Hajra A, Bandyopadhyay D |title=An interesting case of renal amyloidosis |journal=Indian J Nephrol |volume=26 |issue=6 |pages=467–469 |date=2016 |pmid=27942184 |pmc=5131391 |doi=10.4103/0971-4065.177143 |url=}}</ref>
**Proteinuria (32%)
*[[ESRD]]
**Nephrotic syndrome (40%)
*Systemic organ involvement
**Chronic renal failure (28%)
 
===Prognosis===
===Prognosis===
*Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [--]%.
After a few years, renal amyloidosis eventually leads to end stage renal disease. Disease progression is worsened in presence of certain factors such as:<ref name="pmid10231478">{{cite journal |vauthors=Kaaroud H, Ben Moussa F, Goucha R, Abderrahim E, Ben Hamida F, Ben Hamida F, Ben Hamida F, Kheder A, Ben Miaz H |title=Influence of surgery on renal amyloidosis |journal=Kidney Int. |volume=55 |issue=5 |pages=2117–2133 |date=May 1999 |pmid=10231478 |doi=10.1046/j.1523-1755.1999.00455.x |url=}}</ref>
*Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
*Steroid administration
*The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
*[[Renal vein thrombosis]]
*[Subtype of disease/malignancy] is associated with the most favorable prognosis.
*[[Infection|Infections]]
*The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
*[[Surgery]]
 
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Latest revision as of 18:57, 8 August 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]

Overview

If left untreated, renal amyoidosis may progress into end stage renal disease. Common complications include chronic renal failure and nephrotic syndrome. After a few years, renal amyloidosis eventually leads to end stage renal disease and it may be accelerated by some factors such as steroid administration, renal vein thrombos, iInfections and surgery.

Natural History, Complications, and Prognosis

Natural History

If renal amyloidosis left untreated it usually manifests as nephrotic range proteinuria and then progresses to acute kidney injury and then end stage renal disease.[1]

Complications

Common complications of renal amyloidosis include:[2][3]

  • ESRD
  • Systemic organ involvement

Prognosis

After a few years, renal amyloidosis eventually leads to end stage renal disease. Disease progression is worsened in presence of certain factors such as:[4]

References

  1. Lohani S, Schuiteman E, Garg L, Yadav D, Zarouk S (2016). "Apolipoprotein C-II Deposition Amyloidosis: A Potential Misdiagnosis as Light Chain Amyloidosis". Case Rep Nephrol. 2016: 8690642. doi:10.1155/2016/8690642. PMC 5093243. PMID 27840752.
  2. Bilginer Y, Akpolat T, Ozen S (August 2011). "Renal amyloidosis in children". Pediatr. Nephrol. 26 (8): 1215–27. doi:10.1007/s00467-011-1797-x. PMC 3119800. PMID 21360109.
  3. Hajra A, Bandyopadhyay D (2016). "An interesting case of renal amyloidosis". Indian J Nephrol. 26 (6): 467–469. doi:10.4103/0971-4065.177143. PMC 5131391. PMID 27942184.
  4. Kaaroud H, Ben Moussa F, Goucha R, Abderrahim E, Ben Hamida F, Ben Hamida F, Ben Hamida F, Kheder A, Ben Miaz H (May 1999). "Influence of surgery on renal amyloidosis". Kidney Int. 55 (5): 2117–2133. doi:10.1046/j.1523-1755.1999.00455.x. PMID 10231478.

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