RPS6KB2

Ribosomal protein S6 kinase, 70kDa, polypeptide 2
Identifiers
Symbols	RPS6KB2 ; KLS; P70-beta; P70-beta-1; P70-beta-2; S6K-beta2; S6K2; SRK; STK14B; p70(S6K)-beta; p70S6Kb
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68374
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RPS6KB2 203777 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ribosomal protein S6 kinase, 70kDa, polypeptide 2, also known as RPS6KB2, is a human gene.

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.

Further reading

• Gout I, Minami T, Hara K; et al. (1998). "Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region". J. Biol. Chem. 273 (46): 30061–4. PMID 9804755.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saitoh M, ten Dijke P, Miyazono K, Ichijo H (1999). "Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases". Biochem. Biophys. Res. Commun. 253 (2): 470–6. doi:10.1006/bbrc.1998.9784. PMID 9878560.CS1 maint: Multiple names: authors list (link)
• Lee-Fruman KK, Kuo CJ, Lippincott J; et al. (1999). "Characterization of S6K2, a novel kinase homologous to S6K1". Oncogene. 18 (36): 5108–14. doi:10.1038/sj.onc.1202894. PMID 10490847.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koh H, Jee K, Lee B; et al. (1999). "Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt". Oncogene. 18 (36): 5115–9. doi:10.1038/sj.onc.1202895. PMID 10490848.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martin KA, Schalm SS, Richardson C; et al. (2001). "Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway". J. Biol. Chem. 276 (11): 7884–91. doi:10.1074/jbc.M006969200. PMID 11108711.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martin KA, Schalm SS, Romanelli A; et al. (2001). "Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation". J. Biol. Chem. 276 (11): 7892–8. doi:10.1074/jbc.M009972200. PMID 11108720.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Minami T, Hara K, Oshiro N; et al. (2002). "Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha". Genes Cells. 6 (11): 1003–15. PMID 11733037.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pardo OE, Arcaro A, Salerno G; et al. (2002). "Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells". Oncogene. 20 (52): 7658–67. doi:10.1038/sj.onc.1204994. PMID 11753643.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park IH, Bachmann R, Shirazi H, Chen J (2002). "Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin". J. Biol. Chem. 277 (35): 31423–9. doi:10.1074/jbc.M204080200. PMID 12087098.CS1 maint: Multiple names: authors list (link)
• Kanayasu-Toyoda T, Yamaguchi T, Oshizawa T; et al. (2002). "Role of the p70 S6 kinase cascade in neutrophilic differentiation and proliferation of HL-60 cells-a study of transferrin receptor-positive and -negative cells obtained from dimethyl sulfoxide- or retinoic acid-treated HL-60 cells". Arch. Biochem. Biophys. 405 (1): 21–31. PMID 12176053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Valovka T, Verdier F, Cramer R; et al. (2003). "Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization". Mol. Cell. Biol. 23 (3): 852–63. PMID 12529391.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Levy Y, Ronen D, Bershadsky AD, Zick Y (2003). "Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin". J. Biol. Chem. 278 (16): 14533–42. doi:10.1074/jbc.M207380200. PMID 12569102.CS1 maint: Multiple names: authors list (link)
• Phin S, Kupferwasser D, Lam J, Lee-Fruman KK (2003). "Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1". Biochem. J. 373 (Pt 2): 583–91. doi:10.1042/BJ20021794. PMID 12713446.CS1 maint: Multiple names: authors list (link)
• Kanayasu-Toyoda T, Yamaguchi T, Oshizawa T; et al. (2003). "The role of c-Myc on granulocyte colony-stimulating factor-dependent neutrophilic proliferation and differentiation of HL-60 cells". Biochem. Pharmacol. 66 (1): 133–40. PMID 12818373.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• An WL, Cowburn RF, Li L; et al. (2003). "Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease". Am. J. Pathol. 163 (2): 591–607. PMID 12875979.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shao J, Evers BM, Sheng H (2004). "Roles of phosphatidylinositol 3'-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells". Cancer Res. 64 (1): 229–35. PMID 14729629.CS1 maint: Multiple names: authors list (link)
• Lekmine F, Sassano A, Uddin S; et al. (2004). "Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein". Exp. Cell Res. 295 (1): 173–82. doi:10.1016/j.yexcr.2003.12.021. PMID 15051500.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Raught B, Peiretti F, Gingras AC; et al. (2005). "Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases". EMBO J. 23 (8): 1761–9. doi:10.1038/sj.emboj.7600193. PMID 15071500.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)