RBP1

Retinol binding protein 1, cellular
File:PBB Protein RBP1 image.jpg PDB rendering based on 1crb.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1crb​, 1jbh​, 1kgl​, 1mx7​, 1mx8​
Identifiers
Symbols	RBP1 ; CRABP-I; CRBP; CRBP1; RBPC
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2175
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RBP1 203423 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Retinol binding protein 1, cellular, also known as RBP1, is a human gene.

RBP1 is the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. The gene harbors four exons encoding 24, 59, 33, and 16 amino acid residues respectively. The second intervening sequence alone occupies 19 kb of the 21 kb of the gene.

Further reading

• Herr FM, Ong DE (1992). "Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins". Biochemistry. 31 (29): 6748–55. PMID 1322170.
• Siegenthaler G, Tomatis I, Chatellard-Gruaz D; et al. (1992). "Expression of CRABP-I and -II in human epidermal cells. Alteration of relative protein amounts is linked to the state of differentiation". Biochem. J. 287 ( Pt 2): 383–9. PMID 1332671.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aström A, Tavakkol A, Pettersson U; et al. (1991). "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro". J. Biol. Chem. 266 (26): 17662–6. PMID 1654334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wei LN, Mertz JR, Goodman DS, Nguyen-Huu MC (1990). "Cellular retinoic acid- and cellular retinol-binding proteins: complementary deoxyribonucleic acid cloning, chromosomal assignment, and tissue specific expression". Mol. Endocrinol. 1 (8): 526–34. PMID 2856408.CS1 maint: Multiple names: authors list (link)
• Colantuoni V, Cortese R, Nilsson M; et al. (1985). "Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein". Biochem. Biophys. Res. Commun. 130 (1): 431–9. PMID 2992469.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nilsson MH, Spurr NK, Lundvall J; et al. (1988). "Human cellular retinol-binding protein gene organization and chromosomal location". Eur. J. Biochem. 173 (1): 35–44. PMID 3356192.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sherman DR, Lloyd RS, Chytil F (1987). "Rat cellular retinol-binding protein: cDNA sequence and rapid retinol-dependent accumulation of mRNA". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3209–13. PMID 3472205.CS1 maint: Multiple names: authors list (link)
• Kooistra T, Lansink M, Arts J; et al. (1995). "Involvement of retinoic acid receptor alpha in the stimulation of tissue-type plasminogen-activator gene expression in human endothelial cells". Eur. J. Biochem. 232 (2): 425–32. PMID 7556191.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jaconi S, Rose K, Hughes GJ; et al. (1995). "Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure". J. Lipid Res. 36 (6): 1247–53. PMID 7666002.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu W, Hellman P, Li Q; et al. (1997). "Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells". Biochem. Biophys. Res. Commun. 229 (3): 922–9. doi:10.1006/bbrc.1996.1903. PMID 9005841.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sundaram M, Sivaprasadarao A, DeSousa MM, Findlay JB (1998). "The transfer of retinol from serum retinol-binding protein to cellular retinol-binding protein is mediated by a membrane receptor". J. Biol. Chem. 273 (6): 3336–42. PMID 9452451.CS1 maint: Multiple names: authors list (link)
• De Baere E, Speleman F, Van Roy N; et al. (1999). "Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 226–7. PMID 9858824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Christensen EI, Moskaug JO, Vorum H; et al. (1999). "Evidence for an essential role of megalin in transepithelial transport of retinol". J. Am. Soc. Nephrol. 10 (4): 685–95. PMID 10203351.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Skowyra D, Zeremski M, Neznanov N; et al. (2001). "Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex". J. Biol. Chem. 276 (12): 8734–9. doi:10.1074/jbc.M007664200. PMID 11118440.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Folli C, Calderone V, Ottonello S; et al. (2001). "Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein". Proc. Natl. Acad. Sci. U.S.A. 98 (7): 3710–5. doi:10.1073/pnas.061455898. PMID 11274389.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Orlandi A, Francesconi A, Clément S; et al. (2002). "High levels of cellular retinol binding protein-1 expression in leiomyosarcoma: possible implications for diagnostic evaluation". Virchows Arch. 441 (1): 31–40. doi:10.1007/s00428-001-0576-7. PMID 12111198.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cvetković D, Williams SJ, Hamilton TC (2003). "Loss of cellular retinol-binding protein 1 gene expression in microdissected human ovarian cancer". Clin. Cancer Res. 9 (3): 1013–20. PMID 12631600.CS1 maint: Multiple names: authors list (link)
• Hosaka B, Park SI, Felipe CR; et al. (2004). "Predictive value of urinary retinol binding protein for graft dysfunction after kidney transplantation". Transplant. Proc. 35 (4): 1341–3. PMID 12826154.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schmitt-Gräff A, Ertelt V, Allgaier HP; et al. (2003). "Cellular retinol-binding protein-1 in hepatocellular carcinoma correlates with beta-catenin, Ki-67 index, and patient survival". Hepatology. 38 (2): 470–80. doi:10.1053/jhep.2003.50321. PMID 12883492.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)