RBBP8

Retinoblastoma binding protein 8
Identifiers
Symbols	RBBP8 ; CTIP; RIM
External IDs	Template:OMIM5 Template:MGI HomoloGene: 28546
Gene ontology
RNA expression pattern
File:PBB GE RBBP8 203344 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Retinoblastoma binding protein 8, also known as RBBP8, is a human gene.

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

Further reading

• Deng CX, Brodie SG (2000). "Roles of BRCA1 and its interacting proteins". Bioessays. 22 (8): 728–37. doi:10.1002/1521-1878(200008)22:8<728::AID-BIES6>3.0.CO;2-B. PMID 10918303.
• Matoba R, Okubo K, Hori N; et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. PMID 8076819.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schaeper U, Subramanian T, Lim L; et al. (1998). "Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif". J. Biol. Chem. 273 (15): 8549–52. PMID 9535825.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fusco C, Reymond A, Zervos AS (1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics. 51 (3): 351–8. doi:10.1006/geno.1998.5368. PMID 9721205.CS1 maint: Multiple names: authors list (link)
• Yu X, Wu LC, Bowcock AM; et al. (1998). "The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression". J. Biol. Chem. 273 (39): 25388–92. PMID 9738006.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wong AK, Ormonde PA, Pero R; et al. (1998). "Characterization of a carboxy-terminal BRCA1 interacting protein". Oncogene. 17 (18): 2279–85. doi:10.1038/sj.onc.1202150. PMID 9811458.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li S, Chen PL, Subramanian T; et al. (1999). "Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage". J. Biol. Chem. 274 (16): 11334–8. PMID 10196224.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meloni AR, Smith EJ, Nevins JR (1999). "A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9574–9. PMID 10449734.CS1 maint: Multiple names: authors list (link)
• Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–43. PMID 10608806.CS1 maint: Multiple names: authors list (link)
• Yu X, Baer R (2000). "Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor". J. Biol. Chem. 275 (24): 18541–9. doi:10.1074/jbc.M909494199. PMID 10764811.
• Dick FA, Sailhamer E, Dyson NJ (2000). "Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins". Mol. Cell. Biol. 20 (10): 3715–27. PMID 10779361.CS1 maint: Multiple names: authors list (link)
• Fanciulli M, Bruno T, Di Padova M; et al. (2000). "Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb". FASEB J. 14 (7): 904–12. PMID 10783144.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li S, Ting NS, Zheng L; et al. (2000). "Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response". Nature. 406 (6792): 210–5. doi:10.1038/35018134. PMID 10910365.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zheng L, Pan H, Li S; et al. (2000). "Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1". Mol. Cell. 6 (4): 757–68. PMID 11090615.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Izutsu K, Kurokawa M, Imai Y; et al. (2001). "The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling". Blood. 97 (9): 2815–22. PMID 11313276.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Melhuish TA, Gallo CM, Wotton D (2001). "TGIF2 interacts with histone deacetylase 1 and represses transcription". J. Biol. Chem. 276 (34): 32109–14. doi:10.1074/jbc.M103377200. PMID 11427533.CS1 maint: Multiple names: authors list (link)
• Wu-Baer F, Baer R (2001). "Effect of DNA damage on a BRCA1 complex". Nature. 414 (6859): 36. doi:10.1038/35102118. PMID 11689934.
• Sum EY, Peng B, Yu X; et al. (2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10): 7849–56. doi:10.1074/jbc.M110603200. PMID 11751867.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koipally J, Georgopoulos K (2002). "Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression". J. Biol. Chem. 277 (26): 23143–9. doi:10.1074/jbc.M202079200. PMID 11959865.