RASA3: Difference between revisions

Jump to navigation Jump to search
m (Bot: HTTP→HTTPS)
m (Adding 0 arxiv eprint(s), 2 bibcode(s) and 0 doi(s). Did it miss something? Report bugs, errors, and suggestions at User talk:Bibcode Bot)
Line 1: Line 1:
{{Infobox_gene}}
{{Infobox_gene}}
'''Ras GTPase-activating protein 3''' is an [[enzyme]] that in humans is encoded by the ''RASA3'' [[gene]].<ref name="pmid7637787">{{cite journal |vauthors=Cullen PJ, Hsuan JJ, Truong O, Letcher AJ, Jackson TR, Dawson AP, Irvine RF | title = Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family | journal = Nature | volume = 376 | issue = 6540 | pages = 527–30 |date=Sep 1995 | pmid = 7637787 | pmc =  | doi = 10.1038/376527a0 }}</ref><ref name="pmid9382842">{{cite journal |vauthors=Lockyer PJ, Bottomley JR, Reynolds JS, McNulty TJ, Venkateswarlu K, Potter BV, Dempsey CE, Cullen PJ | title = Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting | journal = Curr Biol | volume = 7 | issue = 12 | pages = 1007–10 |date=Feb 1998 | pmid = 9382842 | pmc =  | doi =10.1016/S0960-9822(06)00423-4  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RASA3 RAS p21 protein activator 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22821| accessdate = }}</ref>
'''Ras GTPase-activating protein 3''' is an [[enzyme]] that in humans is encoded by the ''RASA3'' [[gene]].<ref name="pmid7637787">{{cite journal |vauthors=Cullen PJ, Hsuan JJ, Truong O, Letcher AJ, Jackson TR, Dawson AP, Irvine RF | title = Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family | journal = Nature | volume = 376 | issue = 6540 | pages = 527–30 |date=Sep 1995 | pmid = 7637787 | pmc =  | doi = 10.1038/376527a0 | bibcode =1995Natur.376..527C }}</ref><ref name="pmid9382842">{{cite journal |vauthors=Lockyer PJ, Bottomley JR, Reynolds JS, McNulty TJ, Venkateswarlu K, Potter BV, Dempsey CE, Cullen PJ | title = Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting | journal = Curr Biol | volume = 7 | issue = 12 | pages = 1007–10 |date=Feb 1998 | pmid = 9382842 | pmc =  | doi =10.1016/S0960-9822(06)00423-4  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RASA3 RAS p21 protein activator 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22821| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Line 26: Line 26:
*{{cite journal  |vauthors=Koehler JA, Moran MF |title=RACK1, a protein kinase C scaffolding protein, interacts with the PH domain of p120GAP |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 4 |pages= 888–95 |year= 2001 |pmid= 11350068 |doi= 10.1006/bbrc.2001.4889 }}
*{{cite journal  |vauthors=Koehler JA, Moran MF |title=RACK1, a protein kinase C scaffolding protein, interacts with the PH domain of p120GAP |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 4 |pages= 888–95 |year= 2001 |pmid= 11350068 |doi= 10.1006/bbrc.2001.4889 }}
*{{cite journal  |vauthors=Walker SA, Kupzig S, Lockyer PJ, etal |title=Analyzing the role of the putative inositol 1,3,4,5-tetrakisphosphate receptor GAP1IP4BP in intracellular Ca2+ homeostasis |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 48779–85 |year= 2003 |pmid= 12356770 |doi= 10.1074/jbc.M204839200 }}
*{{cite journal  |vauthors=Walker SA, Kupzig S, Lockyer PJ, etal |title=Analyzing the role of the putative inositol 1,3,4,5-tetrakisphosphate receptor GAP1IP4BP in intracellular Ca2+ homeostasis |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 48779–85 |year= 2003 |pmid= 12356770 |doi= 10.1074/jbc.M204839200 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal  |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal  |vauthors=Battram AM, Durrant TN, Agbani EO, etal |title=The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3)-binder Rasa3 Regulates Phosphoinositide 3-kinase (PI 3-kinase)-dependent Integrin αIIbβ3 Outside-in Signaling |journal=J. Biol. Chem. |year= 2016 |pmid= 27903653 |doi= 10.1074/jbc.M116.746867 }}
*{{cite journal  |vauthors=Battram AM, Durrant TN, Agbani EO, etal |title=The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3)-binder Rasa3 Regulates Phosphoinositide 3-kinase (PI 3-kinase)-dependent Integrin αIIbβ3 Outside-in Signaling |journal=J. Biol. Chem. |year= 2016 |pmid= 27903653 |doi= 10.1074/jbc.M116.746867 |volume=292 |pmc=5290945 |pages=1691–1704}}
}}
}}
{{refend}}
{{refend}}

Revision as of 01:37, 26 June 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras GTPase-activating protein 3 is an enzyme that in humans is encoded by the RASA3 gene.[1][2][3]

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.[3]

Interactions

RASA3 has been shown to interact with HCK.[4]

References

  1. Cullen PJ, Hsuan JJ, Truong O, Letcher AJ, Jackson TR, Dawson AP, Irvine RF (Sep 1995). "Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family". Nature. 376 (6540): 527–30. Bibcode:1995Natur.376..527C. doi:10.1038/376527a0. PMID 7637787.
  2. Lockyer PJ, Bottomley JR, Reynolds JS, McNulty TJ, Venkateswarlu K, Potter BV, Dempsey CE, Cullen PJ (Feb 1998). "Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting". Curr Biol. 7 (12): 1007–10. doi:10.1016/S0960-9822(06)00423-4. PMID 9382842.
  3. 3.0 3.1 "Entrez Gene: RASA3 RAS p21 protein activator 3".
  4. Briggs, S D; Bryant S S; Jove R; Sanderson S D; Smithgall T E (Jun 1995). "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck". J. Biol. Chem. UNITED STATES. 270 (24): 14718–24. doi:10.1074/jbc.270.24.14718. ISSN 0021-9258. PMID 7782336.

Further reading