|
|
| (3 intermediate revisions by the same user not shown) |
| Line 1: |
Line 1: |
| {{DrugProjectFormSinglePage
| | #redirect:[[Pyridostigmine]] |
| |authorTag={{AP}}
| |
| |genericName=Pyridostigmine
| |
| |aOrAn=a
| |
| |drugClass=[[cholinesterase inhibitor]]
| |
| |indication=[[myasthenia gravis]]
| |
| |adverseReactions=[[diaphoresis]], [[diarrhea]], [[excessive salivation]], increased peristalsis, [[nausea and vomiting]], [[stomach cramps]], [[muscle fasciculation]], [[asthenia]], [[miosis]] and excessive [[bronchial secretion]]
| |
| |blackBoxWarningTitle=<b><span style="color:#FF0000;">TITLE</span></b>
| |
| |blackBoxWarningBody=<i><span style="color:#FF0000;">Condition Name:</span></i> (Content)
| |
| |fdaLIADAdult======Myasthenia Gravis=====
| |
| Pyridostigmine bromide is available in tablets, each containing 60 mg pyridostigmine bromide.
| |
| *Dosage: The size and frequency of the dosage must be adjusted to the needs of the individual patient. The average dose is ten 60-mg tablets daily, spaced to provide maximum relief when maximum strength is needed. In severe cases as many as 25 tablets a day may be required, while in mild cases one to six tablets a day may suffice.
| |
| |offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Pyridostigmine (patient information) in adult patients.
| |
| |offLabelAdultNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Pyridostigmine (patient information) in adult patients.
| |
| |fdaLIADPed======Myasthenia Gravis=====
| |
| Pyridostigmine bromide is available in tablets, each containing 60 mg pyridostigmine bromide.
| |
| *Dosage: The size and frequency of the dosage must be adjusted to the needs of the individual patient. The average dose is ten 60-mg tablets daily, spaced to provide maximum relief when maximum strength is needed. In severe cases as many as 25 tablets a day may be required, while in mild cases one to six tablets a day may suffice.
| |
| |offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Pyridostigmine (patient information) in pediatric patients.
| |
| |offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Pyridostigmine (patient information) in pediatric patients.
| |
| |contraindications=Pyridostigmine bromide is contraindicated in mechanical intestinal or [[urinary obstruction]], and particular caution should be used in its administration to patients with [[bronchial asthma]]. Care should be observed in the use of [[atropine]] for counteracting side effects, as discussed below.
| |
| |warnings=Although failure of patients to show clinical improvement may reflect underdosage, it can also be indicative of [[overdosage]]. As is true of all [[cholinergic drugs]], overdosage of pyridostigmine bromide may result in [[cholinergic crisis]], a state characterized by increasing [[muscle weakness]] which, through involvement of the muscles of respiration, may lead to death. [[Myasthenic crisis]] due to an increase in the severity of the disease is also accompanied by extreme [[muscle weakness]], and thus may be difficult to distinguish from [[cholinergic crisis]] on a symptomatic basis. Such differentiation is extremely important, since increases in doses of pyridostigmine bromide or other drugs of this class in the presence of cholinergic crisis or of a refractory or "insensitive" state could have grave consequences. Osserman and Genkins indicate that the differential diagnosis of the two types of crisis may require the use of [[Tensilon]] ([[edrophonium chloride]]) as well as clinical judgment. The treatment of the two conditions obviously differs radically. Whereas the presence of myasthenic crisis suggests the need for more intensive anticholinesterase therapy, the diagnosis of cholinergic crisis, according to Osserman and Genkins, calls for the prompt withdrawal of all drugs of this type. The immediate use of [[atropine]] in [[cholinergic crisis]] is also recommended.
| |
| | |
| [[Atropine]] may also be used to abolish or obtund gastrointestinal side effects or other [[muscarinic]] reactions; but such use, by masking signs of overdosage, can lead to inadvertent induction of [[cholinergic crisis]]. For detailed information on the management of patients with [[myasthenia gravis]], the physician is referred to one of the excellent reviews such as those by Osserman and Genkins, Grob or Schwab.
| |
| |clinicalTrials=The side effects of pyridostigmine bromide are most commonly related to overdosage and generally are of two varieties, [[muscarinic]] and [[nicotinic]]. Among those in the former group are [[nausea]], [[vomiting]], [[diarrhea]], abdominal [[cramps]], increased [[peristalsis]], increased [[salivation]], increased bronchial [[secretions]], [[miosis]] and [[diaphoresis]]. [[Nicotinic]] side effects are comprised chiefly of [[muscle cramps]], [[fasciculation]] and [[weakness]]. [[Muscarinic]] side effects can usually be counteracted by [[atropine]], but for reasons shown in the preceding section the expedient is not without danger. As with any compound containing the [[bromide radical]], a skin [[rash]] may be seen in an occasional patient. Such reactions usually subside promptly upon discontinuance of the medication.
| |
| |FDAPregCat=C
| |
| |useInPregnancyFDA=The safety of pyridostigmine bromide during pregnancy or lactation in humans has not been established. Therefore, use of pyridostigmine bromide in women who may become pregnant requires weighing the drug's potential benefits against its possible hazards to mother and child.
| |
| |AUSPregCat=C
| |
| |useInPed=Safety and effectiveness in pediatric patients have not been established.
| |
| |administration=*Pyridostigmine bromide is available in tablets, each containing 60 mg pyridostigmine bromide.
| |
| |drugBox={{Drugbox2
| |
| | verifiedrevid = 464377022
| |
| | IUPAC_name = 3-[(dimethylcarbamoyl)oxy]-1-methylpyridinium
| |
| | image = Pyridostigmine Structure.png
| |
| <!--Clinical data-->
| |
| | tradename = Mestinon
| |
| | Drugs.com = {{drugs.com|monograph|pyridostigmine-bromide}}
| |
| | MedlinePlus = a682229
| |
| | pregnancy_AU = C
| |
| | pregnancy_US = C
| |
| | legal_UK = POM
| |
| | legal_US = Rx-only
| |
| | routes_of_administration = Oral, [[Intravenous therapy|intravenous]]
| |
| | |
| <!--Pharmacokinetic data-->
| |
| | bioavailability = 7.6 +/- 2.4%
| |
| | protein_bound =
| |
| | metabolism =
| |
| | elimination_half-life = 1.78 +/- 0.24hrs
| |
| | excretion = [[Kidney|Renal]]
| |
| | |
| <!--Identifiers-->
| |
| | CASNo_Ref = {{cascite|correct|CAS}}
| |
| | CAS_number_Ref = {{cascite|correct|??}}
| |
| | CAS_number = 155-97-5
| |
| | ATC_prefix = N07
| |
| | ATC_suffix = AA02
| |
| | ATC_supplemental =
| |
| | PubChem = 4991
| |
| | DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| |
| | DrugBank = DB00545
| |
| | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| |
| | ChemSpiderID = 4817
| |
| | UNII_Ref = {{fdacite|correct|FDA}}
| |
| | UNII = 19QM69HH21
| |
| | KEGG_Ref = {{keggcite|correct|kegg}}
| |
| | KEGG = D00487
| |
| | ChEMBL_Ref = {{ebicite|correct|EBI}}
| |
| | ChEMBL = 1115
| |
| | |
| <!--Chemical data-->
| |
| | C=9 | H=13 | N=2 | O=2
| |
| | molecular_weight = 181.212 g/mol
| |
| | smiles = O=C(Oc1ccc[n+](c1)C)N(C)C
| |
| | InChI = 1/C9H13N2O2/c1-10(2)9(12)13-8-5-4-6-11(3)7-8/h4-7H,1-3H3/q+1
| |
| | InChIKey = RVOLLAQWKVFTGE-UHFFFAOYAK
| |
| | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| |
| | StdInChI = 1S/C9H13N2O2/c1-10(2)9(12)13-8-5-4-6-11(3)7-8/h4-7H,1-3H3/q+1
| |
| | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| |
| | StdInChIKey = RVOLLAQWKVFTGE-UHFFFAOYSA-N
| |
| }}
| |
| |mechAction=Pyridostigmine bromide inhibits the destruction of acetylcholine by cholinesterase and thereby permits freer transmission of nerve impulses across the neuromuscular junction.
| |
| |structure=Chemically, pyridostigmine bromide is 3-hydroxy-1-methylpyridinium bromide dimethylcarbamate. Its structural formula is:
| |
| [[file:Pyridostigmine Structure.png|none|350px]]
| |
| |PD=Pyridostigmine is an analog of neostigmine (Prostigmin®), but differs from it in certain clinically significant respects; for example, pyridostigmine is characterized by a longer duration of action and fewer gastrointestinal side effects.
| |
| |howSupplied=[[file:Pyridostigmine How Supplied.png|none|200px]]
| |
| |packLabel=[[file:Pyridostigmine Label.png|none|350px]]
| |
| |alcohol=Alcohol-Pyridostigmine (patient information) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
| |
| }}
| |
| {{LabelImage
| |
| |fileName=Pyridostigmine Package.png
| |
| }}
| |
| {{EH}}
| |
| | |
| {{drug header}}
| |
| | |
| ==Why is this medication prescribed==
| |
| Pyridostigmine is used to decrease muscle weakness resulting from myasthenia gravis.
| |
| | |
| This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
| |
| | |
| ==How should this medicine be used==
| |
| Pyridostigmine comes as a regular tablet, an extended-release (long-acting) tablet, and a syrup to take by mouth. It usually is taken once, twice, or several times a day, depending on the type of tablet. Your doctor may change your dose, depending on how you respond to the drug. When you first start taking pyridostigmine, your doctor may want you to keep a daily record of the time you take each dose, how long you feel better after taking each dose, and if you have side effects. This record will help the doctor decide how much drug is best for you.
| |
| | |
| Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pyridostigmine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
| |
| | |
| Continue to take pyridostigmine even if you feel well. Do not stop taking pyridostigmine without talking to your doctor.
| |
| | |
| Pyridostigmine overdose can cause severe illness, including muscle weakness. It is very hard to tell the difference between too little and too much pyridostigmine. Call your doctor immediately if your symptoms become worse.
| |
| | |
| ==What special precautions should I follow==
| |
| '''Before taking pyridostigmine:'''
| |
| | |
| *tell your doctor and pharmacist if you are allergic to pyridostigmine, bromides, or any other drugs.
| |
| *tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially allergy or cold medications, dexamethasone (Decadron), hydrocortisone (Hydrocortone), magnesium-containing products, medications for heart arrhythmias, sleeping pills, and vitamins.
| |
| *tell your doctor if you have or have ever had intestinal or bladder blockage, asthma, seizures, heart or kidney disease, thyroid problems, or stomach ulcers.
| |
| *tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking pyridostigmine, call your doctor.
| |
| *you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
| |
| *remember that alcohol can add to the drowsiness caused by this drug.
| |
| | |
| ==What special dietary instructions should I follow==
| |
| Pyridostigmine may cause an upset stomach. Take pyridostigmine with food or milk.
| |
| | |
| ==What should I do if I forget a dose==
| |
| Take the missed dose as soon as you remember it. However, if you remember a missed dose near the time you are supposed to take the next dose, take only the regularly scheduled dose. Do not take a double dose to make up for a missed one.
| |
| | |
| ==Side effects==
| |
| ===Mild side effects===
| |
| ''Pyridostigmine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:''
| |
| | |
| *upset stomach
| |
| *diarrhea
| |
| *vomiting
| |
| *drooling
| |
| *pale skin
| |
| *cold sweats
| |
| *blurred vision
| |
| *watery eyes
| |
| *increased urge to urinate
| |
| *anxiousness and feelings of panic
| |
| *muscle weakness
| |
| | |
| ===Severe side effects===
| |
| ''If you experience any of the following symptoms, call your doctor immediately:''
| |
| | |
| *severe itching, skin rash, or hives
| |
| *slurred speech
| |
| *confusion
| |
| *seizures
| |
| *difficulty breathing
| |
| | |
| If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/report.htm] or by phone [1-800-332-1088].
| |
| | |
| ==What storage conditions are needed for this medicine==
| |
| Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
| |
| | |
| ==In case of emergency/overdose==
| |
| In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
| |
| | |
| ==What other information should I know==
| |
| Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to pyridostigmine.
| |
| | |
| Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
| |
| | |
| ==Brand names==
| |
| *Mestinon®
| |
| *Mestinon® Syrup
| |
| *Mestinon® Timespan®
| |
| | |
| [[Category:Musculoskeletal Drugs]]
| |
| | |
| {{WH}}
| |
| {{WS}}
| |