Pyelonephritis pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathophysiology
Following important aspects about the pathophysiology of Pyelonephritis need to be understood:[1][2][3][4]
- Pyelonephritis results mostly from an ascending infection, from the urethral (when colonised by organisms) to bladder and then through the ureters to the renal parenchyma or from a descending infection from the blood itself.
- Uncomplicated pyelonephritis occurs in otherwise healthy individuals and because of the normal defines mechanisms of the body is east to treat and requires a shorter duration of therapy.
- Complicated Pyelonephritis occurs in otherwise unhealthy individual, pregnant or post menopausal women or other immunocompromised patients and thus requires aggressive, long term and broad spectrum treatment.
- Acute pyelonephritis is an exudative purulent localized inflammation of the renal pelvis (collecting system) and kidney.
- The renal parenchyma presents in the interstitium abscesses (suppurative necrosis), consisting of purulent exudate (pus): neutrophils, fibrin, cell debris and central germ colonies (hematoxylinophils).
- Tubules are damaged by exudate and may contain neutrophil casts. In the early stages, glomeruli and vessels are normal.
- A decreased expression of CXCR1 which is a receptor for interleukin 8 is considered to be a reason for pyelonephritis in individuals with positive family history.
- Gross pathology often reveals pathognomonic radiations of hemorrhage and suppuration through the renal pelvis to the renal cortex.
- As the infection progresses and involves the parenchymal lining and then the peritoneum, the irritation and infection can result in mild costovertebral tenderness to severe abdominal pain radiating to back.
- Chronic or recurrent infections result when pathogens like Ecoli invade the epithelium at any place in the urinary tract and avoid body defines mechanism. These reservoirs act as a continuous source of pathogen. Chronic infections can result in fibrosis and scarring of the kidneys.
Emphysematous Pyelonephritis
Emphysematous Pyelonepritis is caused by bacteria following the same pathogenesis as described above. It is a necrotising infection of the renal substance with production of gas. The gas accumulates in the parenchyma of the kidney, the perinephric space and the collecting system. Majority of the patients with emphysematous pyelonephritis have diabetes mellitus.[5][6][7]
Xanthogranulomatous Pyelonephritis
Xanthogranulomatous Pyelonephritis is a rare type of pyelonephritis. It is associated with nephrolithiasis. Many kidney stones are seen and stag horn calculi can also be noticed. Xanthogranulomatous pyelonephritis is usually confused due to its appearance, with a malignancy and aggressive management requiring a surgical resection is done. The histopathology of the specimen confirms xanthogranulomatous pyelonephritis rather than a tumour. The initial presentation can be abdominal distention owing to the formation of a peritoneal abscess. Proteus is the most common organism involved in case of a peritoneal abscess associated with xanthogranulomatous pyelonephritis.[8]
Gross Pathology
Gross pathology often reveals pathognomonic radiations of hemorrhage and suppuration through the renal pelvis to the renal cortex. Chronic infections can result in fibrosis and scarring.
Microscopic Pathology
Acute pyelonephritis
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Chronic pyelonephritis
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References
- ↑ Johnson JR (2003). "Microbial virulence determinants and the pathogenesis of urinary tract infection". Infect Dis Clin North Am. 17 (2): 261–78, viii. PMID 12848470.
- ↑ Nielubowicz GR, Mobley HL (2010). "Host-pathogen interactions in urinary tract infection". Nat Rev Urol. 7 (8): 430–41. doi:10.1038/nrurol.2010.101. PMID 20647992.
- ↑ Rosen DA, Hooton TM, Stamm WE, Humphrey PA, Hultgren SJ (2007). "Detection of intracellular bacterial communities in human urinary tract infection". PLoS Med. 4 (12): e329. doi:10.1371/journal.pmed.0040329. PMC 2140087. PMID 18092884.
- ↑ Lundstedt AC, Leijonhufvud I, Ragnarsdottir B, Karpman D, Andersson B, Svanborg C (2007). "Inherited susceptibility to acute pyelonephritis: a family study of urinary tract infection". J Infect Dis. 195 (8): 1227–34. doi:10.1086/512620. PMID 17357062.
- ↑ Hirose Y, Kaida H (2016). "Emphysematous Pyelonephritis". N Engl J Med. 375 (17): 1671. doi:10.1056/NEJMicm1501812. PMID 27783923.
- ↑ Ambaram PR, Kala UK, Petersen KL (2016). "Emphysematous Pyelonephritis in Children". Pediatr Infect Dis J. 35 (10): 1159–61. doi:10.1097/INF.0000000000001254. PMID 27622688.
- ↑ Misgar RA, Mubarik I, Wani AI, Bashir MI, Ramzan M, Laway BA (2016). "Emphysematous pyelonephritis: A 10-year experience with 26 cases". Indian J Endocrinol Metab. 20 (4): 475–80. doi:10.4103/2230-8210.183475. PMC 4911836. PMID 27366713.
- ↑ Yeow Y, Chong YL (2016). "Xanthogranulomatous pyelonephritis presenting as Proteus preperitoneal abscess". J Surg Case Rep. 2016 (12). doi:10.1093/jscr/rjw211. PMC 5159021. PMID 27915241.