Postpartum thyroiditis historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Historical Perspective

[1]

Discovery

    • 1946: Postpartum thyroid dysfunction was first discovered by Dr. W.E.H. Robertson, a British physician, who diagnosed postpartum patients with symptoms of hypothyroidism after pregnancy and their improvement on treatment with thyroid extracts.[2]
    • 1308-1340: Postpartum thyroid dysfunction was first observed in pictures of Madonna Enthroned by Duccio and Lorenzetti holding child in lap with Goiter which later proved by Dr Glinoer D 1997 due to iodine deficiency of postpartum thyroid dysfunction.
    • 1786: Parry CH who observed signs of hyperthyroidism in postpartum women and paper published in 1825.
    • 1868: Dr. Armand Trousseau, observed signs of hypothyroidisum in postpartum patients who got relief from symptoms on end of postpartum and establishment of menstrual cycle or conception but he could not connect relation of hypothyroidism to postpartum. His literature says "goitre occurring in pregnant women is apparently due to pregnancy, while that of exophthalmos is seemingly cured by pregnancy"
    • 1988: Sir H. Bryan Donkin associated symptoms of hypothyroidism related to pregnancy which got better after the end of postpartum period.
    • 1953: Danowski and colleagues, compared levels of serum protein-bound iodine (PBI) during and after pregnancy and postpartum period, and found them low in postpartum and improving after postpartum period.
    • 1961: Parker and Beierwaltes found antithyroid antibodies decreasing in pregnancy and increasing in postpartum period.
    • In 1982, Amino and colleagues were the first to discover the association between postpartum period and the development of transient hyperthyroidism and/or hypothyroidism with prevalence of 5.5% of 505 Japanese women.
    • In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].Postpartum thyroid dysfunction was first discovered by Dr. W.E.H. Robertson, a British physician, in 1946, who diagnosed postpartum patients with symptoms of hypothyroidism after pregnancy and their improvement on treatment with thyroid extracts.[3]
  • Postpartum thyoidtis was first considered as Postpartum thyroid dysfunction until 1988
  • There has been evidence of Postpartum thyroid dysfunction
  • The association between [important risk factor/cause] and [disease name] was made in/during [year/event].
  • In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
  • In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].

Outbreaks

  • There have been several outbreaks of [disease name], which are summarized below:

Landmark Events in the Development of Treatment Strategies

  • In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].

Impact on Cultural History

Famous Cases

References

  1. Premawardhana LD, Parkes AB, Ammari F, John R, Darke C, Adams H, Lazarus JH (2000). "Postpartum thyroiditis and long-term thyroid status: prognostic influence of thyroid peroxidase antibodies and ultrasound echogenicity". J. Clin. Endocrinol. Metab. 85 (1): 71–5. doi:10.1210/jcem.85.1.6227. PMID 10634366.
  2. Smallridge, Robert C. (1999). "Postpartum Thyroid Diseases Through The Ages: A Historical View". Thyroid. 9 (7): 671–673. doi:10.1089/thy.1999.9.671. ISSN 1050-7256.
  3. Smallridge, Robert C. (1999). "Postpartum Thyroid Diseases Through The Ages: A Historical View". Thyroid. 9 (7): 671–673. doi:10.1089/thy.1999.9.671. ISSN 1050-7256.

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