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*1868: Dr. Armand Trousseau, observed signs of hypothyroidisum in postpartum patients who got relief from symptoms on end of postpartum and establishment of menstrual cycle or conception but he could not connect relation of hypothyroidism to postpartum. His literature says "goitre occurring in pregnant women is apparently due to pregnancy, while that of exophthalmos is seemingly cured by pregnancy"{{cite web |url=https://archive.org/details/lecturesonclinic01trouuoft |title=Lectures on clinical medicine, delivered at the Hotel-Dieu, Paris. Translated and edited with notes and appendices by P. Victor Bazire : Trousseau, Armand, 1801-1867 : Free Download & Streaming : Internet Archive |format= |work= |accessdate=}}
*1868: Dr. Armand Trousseau, observed signs of hypothyroidisum in postpartum patients who got relief from symptoms on end of postpartum and establishment of menstrual cycle or conception but he could not connect relation of hypothyroidism to postpartum. His literature says "goitre occurring in pregnant women is apparently due to pregnancy, while that of exophthalmos is seemingly cured by pregnancy"{{cite web |url=https://archive.org/details/lecturesonclinic01trouuoft |title=Lectures on clinical medicine, delivered at the Hotel-Dieu, Paris. Translated and edited with notes and appendices by P. Victor Bazire : Trousseau, Armand, 1801-1867 : Free Download & Streaming : Internet Archive |format= |work= |accessdate=}}
*1988: Dr. Sawin, was first to report postpartum hypothyroidism case number 16 in the seminal report of myxedeoma.<ref name="LindholmLaurberg2011">{{cite journal|last1=Lindholm|first1=J.|last2=Laurberg|first2=P.|title=Hypothyroidism and Thyroid Substitution: Historical Aspects|journal=Journal of Thyroid Research|volume=2011|year=2011|pages=1–10|issn=2042-0072|doi=10.4061/2011/809341}}</ref>
*1888: Dr. Sawin, was first to report postpartum hypothyroidism case number 16 in the seminal report of myxedeoma.<ref name="LindholmLaurberg2011">{{cite journal|last1=Lindholm|first1=J.|last2=Laurberg|first2=P.|title=Hypothyroidism and Thyroid Substitution: Historical Aspects|journal=Journal of Thyroid Research|volume=2011|year=2011|pages=1–10|issn=2042-0072|doi=10.4061/2011/809341}}</ref>


*1988: Sir H. Bryan Donkin, British physician, associated symptoms of hypothyroidism related to pregnancy which got better after the end of postpartum period.<ref name="Landek-SalgadoGutenberg2010">{{cite journal|last1=Landek-Salgado|first1=Melissa A.|last2=Gutenberg|first2=Angelika|last3=Lupi|first3=Isabella|last4=Kimura|first4=Hiroaki|last5=Mariotti|first5=Stefano|last6=Rose|first6=Noel R.|last7=Caturegli|first7=Patrizio|title=Pregnancy, postpartum autoimmune thyroiditis, and autoimmune hypophysitis: Intimate relationships|journal=Autoimmunity Reviews|volume=9|issue=3|year=2010|pages=153–157|issn=15689972|doi=10.1016/j.autrev.2009.06.001}}</ref>
*1888: Sir H. Bryan Donkin, British physician, associated symptoms of hypothyroidism related to pregnancy which got better after the end of postpartum period.<ref name="Landek-SalgadoGutenberg2010">{{cite journal|last1=Landek-Salgado|first1=Melissa A.|last2=Gutenberg|first2=Angelika|last3=Lupi|first3=Isabella|last4=Kimura|first4=Hiroaki|last5=Mariotti|first5=Stefano|last6=Rose|first6=Noel R.|last7=Caturegli|first7=Patrizio|title=Pregnancy, postpartum autoimmune thyroiditis, and autoimmune hypophysitis: Intimate relationships|journal=Autoimmunity Reviews|volume=9|issue=3|year=2010|pages=153–157|issn=15689972|doi=10.1016/j.autrev.2009.06.001}}</ref>
*1891: Dr. George R. Murray,  English physician, who successfully treated hypothyroid patient after miscarriage with sheep extract of thyroid.


*1953: Danowski and colleagues, compared levels of serum protein-bound iodine (PBI) during and after pregnancy and postpartum period, and found them low in postpartum and improving after postpartum period.
*1953: Danowski and colleagues, compared levels of serum protein-bound iodine (PBI) during and after pregnancy and postpartum period, and found them low in postpartum and improving after postpartum period.

Revision as of 02:34, 28 September 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Postpartum thyroid dysfunction was first discovered by Dr. W.E.H. Robertson, a British physician, who diagnosed postpartum patients with symptoms of hypothyroidism after pregnancy and their improvement on treatment with thyroid extracts in 1946.

Historical Perspective

Discovery

  • 1946: Postpartum thyroid dysfunction was first discovered by Dr. W.E.H. Robertson, a British physician, who diagnosed postpartum patients with symptoms of hypothyroidism after pregnancy and their improvement on treatment with thyroid extracts.[1]
  • 98-138 AD: PPT was first observed by Soranus, Roman gynecologist, as neck swelling after birth of baby which he published in book Gynaecia.[2]
  • 1308-1340: Postpartum thyroid dysfunction was first observed in pictures of Madonna Enthroned by Duccio and Lorenzetti holding child in lap with Goiter which later proved by Dr Glinoer D 1997 due to iodine deficiency leading to postpartum thyroid dysfunction.[3]
  • 1786: Parry CH , British physician, who observed signs of hyperthyroidism in postpartum women which he described in his paper published in the posthumous publication.[4]
  • 1868: Dr. Armand Trousseau, observed signs of hypothyroidisum in postpartum patients who got relief from symptoms on end of postpartum and establishment of menstrual cycle or conception but he could not connect relation of hypothyroidism to postpartum. His literature says "goitre occurring in pregnant women is apparently due to pregnancy, while that of exophthalmos is seemingly cured by pregnancy""Lectures on clinical medicine, delivered at the Hotel-Dieu, Paris. Translated and edited with notes and appendices by P. Victor Bazire : Trousseau, Armand, 1801-1867 : Free Download & Streaming : Internet Archive".
  • 1888: Dr. Sawin, was first to report postpartum hypothyroidism case number 16 in the seminal report of myxedeoma.[5]
  • 1888: Sir H. Bryan Donkin, British physician, associated symptoms of hypothyroidism related to pregnancy which got better after the end of postpartum period.[6]
  • 1891: Dr. George R. Murray,  English physician, who successfully treated hypothyroid patient after miscarriage with sheep extract of thyroid.
  • 1953: Danowski and colleagues, compared levels of serum protein-bound iodine (PBI) during and after pregnancy and postpartum period, and found them low in postpartum and improving after postpartum period.
  • 1961: Parker and Beierwaltes found antithyroid antibodies decreasing in pregnancy and increasing in postpartum period.
  • In 1982, Amino and colleagues were the first to discover the association between postpartum period and the development of transient hyperthyroidism and/or hypothyroidism with prevalence of 5.5% of 505 Japanese women.

Landmark Events in the Development of Treatment Strategies

  • In 1976, Anti-thyroid microsomal antibodies were observed correlation to postpartum thyroisits by Nobuyuki Amino.[7]

Impact on Cultural History

Famous Cases

References

  1. Smallridge, Robert C. (1999). "Postpartum Thyroid Diseases Through The Ages: A Historical View". Thyroid. 9 (7): 671–673. doi:10.1089/thy.1999.9.671. ISSN 1050-7256.
  2. Smallridge, Robert C. (2014). "Clark T. Sawin Historical Vignette: What Do Criminology, Harry Houdini, and King George V Have in Common with Postpartum Thyroid Dysfunction?". Thyroid. 24 (12): 1752–1758. doi:10.1089/thy.2014.0165. ISSN 1050-7256.
  3. Lazzeri, Davide; Castello, ManuelFrancisco; Lippi, Donatella; Weisz, GeorgeM (2016). "Goiter in portraits of Judith the Jewish heroine". Indian Journal of Endocrinology and Metabolism. 20 (1): 119. doi:10.4103/2230-8210.172266. ISSN 2230-8210.
  4. Hamolsky, Milton W.; Kurland, George S.; Freedberg, A.Stone (1961). "The heart in hypothyroidism". Journal of Chronic Diseases. 14 (5): 558–569. doi:10.1016/0021-9681(61)90020-0. ISSN 0021-9681.
  5. Lindholm, J.; Laurberg, P. (2011). "Hypothyroidism and Thyroid Substitution: Historical Aspects". Journal of Thyroid Research. 2011: 1–10. doi:10.4061/2011/809341. ISSN 2042-0072.
  6. Landek-Salgado, Melissa A.; Gutenberg, Angelika; Lupi, Isabella; Kimura, Hiroaki; Mariotti, Stefano; Rose, Noel R.; Caturegli, Patrizio (2010). "Pregnancy, postpartum autoimmune thyroiditis, and autoimmune hypophysitis: Intimate relationships". Autoimmunity Reviews. 9 (3): 153–157. doi:10.1016/j.autrev.2009.06.001. ISSN 1568-9972.
  7. Amino, Nobuyuki; Miyai, Kiyoshi; Onishi, Toshio; Hashimoto, Takuma; Arai, Kayoko; Ishibashi, Kaichiro; Kumahara, Yuichi (1976). "Transient Hypothyroidism After Delivery in Autoimmune Thyroiditis". The Journal of Clinical Endocrinology & Metabolism. 42 (2): 296–301. doi:10.1210/jcem-42-2-296. ISSN 0021-972X.

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