Post-streptococcal glomerulonephritis: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
Line 40: Line 40:
==Case Studies==
==Case Studies==
[[Post-streptococcal glomerulonephritis case study one|Case #1]]
[[Post-streptococcal glomerulonephritis case study one|Case #1]]
In [[nephrology]], '''post-streptococcal glomerulonephritis''' is a disorder of the [[glomerulus|glomeruli]] ([[glomerulonephritis]]), or small blood vessels in the kidneys, following an [[streptococci]] [[infection]]. This condition is essentially defined as an inflammation of the kidneys.
A closely related term is "post-infectious glomerulonephritis", which accounts for infections by other agents. However, this term is used much less frequently.
==Pathophysiology==
The exact pathology remains unclear, but it is believed to be Type III [[hypersensitivity]] reaction.  Immune complexes (antigen-antibody complexes formed during an infection) become lodged in the [[glomerular basement membrane]].  [[Complement system|Complement]] activation leads to destruction of the basement membrane.  It has also been proposed that specific antigens from certain nephrotoxic streptococcal infections have a high affinity for basement membrane proteins, giving rise to particularly severe, long lasting antibody response. 


==Presentation==
==Presentation==
Patients will present with acute [[nephritic syndrome]], with the pentad of [[hypertension]], decrease in [[glomerular filtration rate]], [[hematuria]], [[proteinuria]] and [[fluid retention]].
Patients will present with acute [[nephritic syndrome]], with the pentad of [[hypertension]], decrease in [[glomerular filtration rate]], [[hematuria]], [[proteinuria]] and [[fluid retention]].
==Causes==
Post-infectious glomerulonephritis can be a complication of [[streptococcal pharyngitis]] (strep throat).
==Diagnosis==
Diagnosis rarely requires a renal biopsy since there is usually a classical clinical presentation.
There will be elevated levels of ASOT Ab and low complement levels in the blood.


==External links==
==External links==

Revision as of 16:59, 27 September 2012

Post-streptococcal glomerulonephritis
ICD-9 580.0
DiseasesDB 29306
MedlinePlus 000503

Post-streptococcal glomerulonephritis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Post-streptococcal glomerulonephritis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic study of choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Post-streptococcal glomerulonephritis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Post-streptococcal glomerulonephritis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Post-streptococcal glomerulonephritis

CDC on Post-streptococcal glomerulonephritis

Post-streptococcal glomerulonephritis in the news

Blogs on Post-streptococcal glomerulonephritis

Directions to Hospitals Treating Post-streptococcal glomerulonephritis

Risk calculators and risk factors for Post-streptococcal glomerulonephritis

For patient information click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords:: [[Acute proliferative glomerulonephritis]]; post-infectious glomerulonephritis

Overview

Pathophysiology

Causes

Differentiating Post-streptococcal glomerulonephritis from other Diseases

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria | History and Symptoms | Physical Examination | Laboratory Findings | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

Presentation

Patients will present with acute nephritic syndrome, with the pentad of hypertension, decrease in glomerular filtration rate, hematuria, proteinuria and fluid retention.

External links

Template:Nephrology

Template:WH Template:WS