Polyarteritis nodosa overview: Difference between revisions
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==Overview== | ==Overview== | ||
Polyarteritis nodosa is a systemic necrotizing vasculitis that typically affects the medium (and occasionally, small-sized) muscular arteries. Chapel Hill International Consensus Conference (CHCC) has differentiated PAN from microscopic polyangiitis which primarily affects small vessels (Jennette JC, Falk RJ, Bacon PA, et al). | |||
Polyarteritis nodosa is a systemic necrotizing vasculitis that typically affects the medium (and occasionally, small-sized) muscular arteries. Chapel Hill International Consensus Conference (CHCC) has differentiated PAN from microscopic polyangiitis which primarily affects small vessels (Jennette JC, Falk RJ, Bacon PA, et al). | |||
Diagnosis of PAN is very difficult probably because of lack of a serological marker for PAN, and also due to the unavailability of suitable tissue for histological confirmation of diagnosis. Polyarteritis nodosa unlike most other vasculidities is not Antineutrophil Cytoplasmic Antibodies (ANCA) positive (Kallenberg CG et.al). | Diagnosis of PAN is very difficult probably because of lack of a serological marker for PAN, and also due to the unavailability of suitable tissue for histological confirmation of diagnosis. Polyarteritis nodosa unlike most other vasculidities is not Antineutrophil Cytoplasmic Antibodies (ANCA) positive (Kallenberg CG et.al). | ||
Revision as of 14:45, 1 November 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Haritha Machavarapu, M.B.B.S.
Overview
Polyarteritis nodosa is a systemic necrotizing vasculitis that typically affects the medium (and occasionally, small-sized) muscular arteries. Chapel Hill International Consensus Conference (CHCC) has differentiated PAN from microscopic polyangiitis which primarily affects small vessels (Jennette JC, Falk RJ, Bacon PA, et al).
Diagnosis of PAN is very difficult probably because of lack of a serological marker for PAN, and also due to the unavailability of suitable tissue for histological confirmation of diagnosis. Polyarteritis nodosa unlike most other vasculidities is not Antineutrophil Cytoplasmic Antibodies (ANCA) positive (Kallenberg CG et.al).
It is very rare and often present as a systemic disease affecting multiple organs but strikingly, polyarteritis nodosa (PAN) does not affect the lungs. The organs commonly affected by polyarteritis nodosa (PAN) include the kidneys, skin, joints, muscles, nerves, and gastrointestinal tract. PAN often has a multisystem presentation at diagnosis with the exception of variants like single-organ disease and cutaneous-only PAN. PAN has been associated with hepatitis B virus infection.
Polyarteritis nodosa is a vasculitis of medium-sized arteries, which become swollen and damaged from attack by rogue immune cells.