Plasmin

Plasminogen
PDB rendering based on 1b2i.
Identifiers
Symbol(s)	PLG; DKFZp779M0222
External IDs	OMIM: 173350 MGI: 97620 Homologene: 55452
Gene ontology Molecular Function: • plasmin activity • calcium ion binding • protein binding • peptidase activity Cellular Component: • extracellular space Biological Process: • proteolysis • apoptosis • induction of apoptosis • blood coagulation • negative regulation of cell proliferation • negative regulation of angiogenesis • tissue regeneration • fibrinolysis • negative regulation of blood vessel endothelial cell migration • myoblast differentiation • muscle maintenance
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	5340	18815
Ensembl	ENSG00000122194	ENSMUSG00000059481
Uniprot	P00747	Q3V1T9
Refseq	NM_000301 (mRNA) NP_000292 (protein)	NM_008877 (mRNA) NP_032903 (protein)
Location	Chr 6: 161.04 - 161.09 Mb	Chr 17: 12.22 - 12.26 Mb
Pubmed search	[1]	[2]

WikiDoc Resources for Plasmin
Articles
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Evidence Based Medicine
Cochrane Collaboration on Plasmin Bandolier on Plasmin TRIP on Plasmin
Clinical Trials
Ongoing Trials on Plasmin at Clinical Trials.gov Trial results on Plasmin Clinical Trials on Plasmin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Plasmin NICE Guidance on Plasmin NHS PRODIGY Guidance FDA on Plasmin CDC on Plasmin
Books
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Plasmin in the news Be alerted to news on Plasmin News trends on Plasmin
Commentary
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Definitions
Definitions of Plasmin
Patient Resources / Community
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Healthcare Provider Resources
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International
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Business
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Experimental / Informatics
List of terms related to Plasmin

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]

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Overview

Plasmin is an important enzyme (EC 3.4.21.7) present in blood that degrades many blood plasma proteins, most notably fibrin clots. The degradation of fibrin is termed fibrinolysis.

Functions

It is a serine protease that is released as plasminogen into the circulation and activated by tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), thrombin, fibrin and factor XII (Hageman factor). It is inactived by alpha 2-antiplasmin, a serine protease inhibitor (serpin).

Apart from fibrinolysis, plasmin proteolyses proteins in various other systems: it activates collagenases, some mediators of the complement system and weakens the wall of the Graafian follicle (leading to ovulation). It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor.

Pathology

Deficiency in plasmin may lead to thrombosis, as clots are not degraded adequately.

Further reading

• Anglés-Cano E, Rojas G (2003). "Apolipoprotein(a): structure-function relationship at the lysine-binding site and plasminogen activator cleavage site.". Biol. Chem. 383 (1): 93-9. PMID 11928826.
• Ranson M, Andronicos NM (2004). "Plasminogen binding and cancer: promises and pitfalls.". Front. Biosci. 8: s294-304. PMID 12700073.

External links

• MeSH Plasmin

Cost Effectiveness of Plasmin

| group5 = Clinical Trials Involving Plasmin | list5 = Ongoing Trials on Plasmin at Clinical Trials.gov • Trial results on Plasmin • Clinical Trials on Plasmin at Google

| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Plasmin | list6 = US National Guidelines Clearinghouse on Plasmin • NICE Guidance on Plasmin • NHS PRODIGY Guidance • FDA on Plasmin • CDC on Plasmin

| group7 = Textbook Information on Plasmin | list7 = Books and Textbook Information on Plasmin

| group8 = Pharmacology Resources on Plasmin | list8 = AND (Dose)}} Dosing of Plasmin • AND (drug interactions)}} Drug interactions with Plasmin • AND (side effects)}} Side effects of Plasmin • AND (Allergy)}} Allergic reactions to Plasmin • AND (overdose)}} Overdose information on Plasmin • AND (carcinogenicity)}} Carcinogenicity information on Plasmin • AND (pregnancy)}} Plasmin in pregnancy • AND (pharmacokinetics)}} Pharmacokinetics of Plasmin •

| group9 = Genetics, Pharmacogenomics, and Proteinomics of Plasmin | list9 = AND (pharmacogenomics)}} Genetics of Plasmin • AND (pharmacogenomics)}} Pharmacogenomics of Plasmin • AND (proteomics)}} Proteomics of Plasmin

| group10 = Newstories on Plasmin | list10 = Plasmin in the news • Be alerted to news on Plasmin • News trends on Plasmin</small>

| group11 = Commentary on Plasmin | list11 = Blogs on Plasmin

| group12 = Patient Resources on Plasmin | list12 = Patient resources on Plasmin • Discussion groups on Plasmin • Patient Handouts on Plasmin • Directions to Hospitals Treating Plasmin • Risk calculators and risk factors for Plasmin

| group13 = Healthcare Provider Resources on Plasmin | list13 = Symptoms of Plasmin • Causes & Risk Factors for Plasmin • Diagnostic studies for Plasmin • Treatment of Plasmin

| group14 = Continuing Medical Education (CME) Programs on Plasmin | list14 = CME Programs on Plasmin

| group15 = International Resources on Plasmin | list15 = Plasmin en Espanol • Plasmin en Francais

| group16 = Business Resources on Plasmin | list16 = Plasmin in the Marketplace • Patents on Plasmin

| group17 = Informatics Resources on Plasmin | list17 = List of terms related to Plasmin

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