Pheochromocytoma risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]
Overview
Pheochromocytoma is more common in third decade of life, people with family history of multiple endocrine neoplasias, Von Hippel-Lindau disease, neurofibromatosis type 1, hereditary paraganglioma syndromes.
Risk Factors
The most potent risk factors of pheochromocytoma are:
Age
- Occurs in third decade of life; the average age at diagnosis is 24.9 years in hereditary cases and 43.9 years in sporadic cases.[1]
- Hereditary tumors present at a younger age than sporadic.
Family history
Ten percent of pheochromocytomas are linked to hereditary causes:
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- Von Hippel-Lindau disease can result in tumors at multiple sites, including the central nervous system, endocrine system, pancreas and kidneys.
- Neurofibromatosis 1 results in multiple tumors in the skin (neurofibromas), pigmented skin spots and tumors of the optic nerve.
- Hereditary paraganglioma syndromes are inherited disorders that result in either pheochromocytomas or paragangliomas.
References
- ↑ National Cancer Institute. Physician Data Query Database 2015. National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/pheochromocytoma/hp/pheochromocytoma-treatment-pdq#link/_25_toc