Pancytopenia resident survival guide: Difference between revisions
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== Quick-take == | |||
Urgent hematology consult. Send out labs as detailed below. Plan for pt to get bone marrow biopsy. | |||
== Visual summary == | == Visual summary == | ||
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== Differential == | == Differential == | ||
'''Hypercellular bone marrow:''' | '''Hypercellular bone marrow (1/Y):''' | ||
Common: MDS (3-4/100K). | |||
'''Hypocellular bone marrow | |||
Rare: PNH, aleukemic leukemia, severe megaloblastic anemia | |||
'''Hypocellular bone marrow (1/X):''' | |||
Aplastic anemia (BM stem cell failure): idiopathic (most common), viruses (ParvoB19, HIV, EBV, HHV6), meds (chloramphenicol, NSAIDs, sulfa), other infection (anaplasma) | |||
== Workup == | == Workup == | ||
Bone marrow biopsy required for definitive diagnosis. | |||
== Treatment == | == Treatment == | ||
Once identified, treat underlying cause. | Once identified, treat underlying cause. | ||
Aplastic anemia: | |||
== Example A/P == | |||
Revision as of 02:30, 28 May 2016
Quick-take
Urgent hematology consult. Send out labs as detailed below. Plan for pt to get bone marrow biopsy.
Visual summary
Differential
Hypercellular bone marrow (1/Y):
Common: MDS (3-4/100K).
Rare: PNH, aleukemic leukemia, severe megaloblastic anemia
Hypocellular bone marrow (1/X):
Aplastic anemia (BM stem cell failure): idiopathic (most common), viruses (ParvoB19, HIV, EBV, HHV6), meds (chloramphenicol, NSAIDs, sulfa), other infection (anaplasma)
Workup
Bone marrow biopsy required for definitive diagnosis.
Treatment
Once identified, treat underlying cause.
Aplastic anemia: