Palmar plantar erythrodysesthesia risk factors: Difference between revisions
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==Overview== | ==Overview== | ||
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The most common and established risk factors are chemotherapeutic agents. The severity of the condition depends on the dose and frequency of the agent. The data is limited to support any other associated risk factors as the pathophysiology of Palmar plantar erythrodysesthesia is still unknown even though different mechanisms have been postulated. | |||
==Risk Factors== | ==Risk Factors== | ||
Exposure to chemotherapeutic agents has been proven to be an established risk factor. Occurrence of this condition has been linked to dose and prolonged chemotherapeutic drug exposure especially with more continuous IV infusion, daily ingestion and liposomal encapsulationg of PLD which prolong half-life of drug. The use of cooling mechanism, higher number of PLD cycles, and occurrence of mucositis, neutropenia and peripheral neuropathy are possible predictors of PPE. <ref name="pmid194468682">{{cite journal| author=Tanyi JL, Smith JA, Ramos L, Parker CL, Munsell MF, Wolf JK| title=Predisposing risk factors for palmar-plantar erythrodysesthesia when using liposomal doxorubicin to treat recurrent ovarian cancer. | journal=Gynecol Oncol | year= 2009 | volume= 114 | issue= 2 | pages= 219-24 | pmid=19446868 | doi=10.1016/j.ygyno.2009.04.007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19446868 }}</ref> | Exposure to chemotherapeutic agents has been proven to be an established risk factor. Occurrence of this condition has been linked to dose and prolonged chemotherapeutic drug exposure especially with more continuous IV infusion, daily ingestion and liposomal encapsulationg of PLD which prolong half-life of drug. The use of cooling mechanism, higher number of PLD cycles, and occurrence of mucositis, neutropenia and peripheral neuropathy are possible predictors of PPE. <ref name="pmid194468682">{{cite journal| author=Tanyi JL, Smith JA, Ramos L, Parker CL, Munsell MF, Wolf JK| title=Predisposing risk factors for palmar-plantar erythrodysesthesia when using liposomal doxorubicin to treat recurrent ovarian cancer. | journal=Gynecol Oncol | year= 2009 | volume= 114 | issue= 2 | pages= 219-24 | pmid=19446868 | doi=10.1016/j.ygyno.2009.04.007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19446868 }}</ref> | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 14:15, 2 July 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D., Associate Editor(s)-in-Chief: Zain Fatiwala, M.D.
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Overview
The most common and established risk factors are chemotherapeutic agents. The severity of the condition depends on the dose and frequency of the agent. The data is limited to support any other associated risk factors as the pathophysiology of Palmar plantar erythrodysesthesia is still unknown even though different mechanisms have been postulated.
Risk Factors
Exposure to chemotherapeutic agents has been proven to be an established risk factor. Occurrence of this condition has been linked to dose and prolonged chemotherapeutic drug exposure especially with more continuous IV infusion, daily ingestion and liposomal encapsulationg of PLD which prolong half-life of drug. The use of cooling mechanism, higher number of PLD cycles, and occurrence of mucositis, neutropenia and peripheral neuropathy are possible predictors of PPE. [1]
References
- ↑ Tanyi JL, Smith JA, Ramos L, Parker CL, Munsell MF, Wolf JK (2009). "Predisposing risk factors for palmar-plantar erythrodysesthesia when using liposomal doxorubicin to treat recurrent ovarian cancer". Gynecol Oncol. 114 (2): 219–24. doi:10.1016/j.ygyno.2009.04.007. PMID 19446868.