Palmar plantar erythrodysesthesia natural history, complications, and prognosis: Difference between revisions
Mchitsazan (talk | contribs) |
Mchitsazan (talk | contribs) |
||
Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{Palmar plantar erythrodysesthesia}} | {{Palmar plantar erythrodysesthesia}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}}[[Mandana Chitsazan, M.D.]] | ||
==Overview== | ==Overview== | ||
If left untreated, | If left untreated, PPE can progress rapidly. | ||
Prognosis is generally good and symptoms usually resolve within 1-2 weeks after stopping the causative chemotherapeutic agent. | |||
Prognosis is generally | |||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
===Natural History=== | ===Natural History=== | ||
*The symptoms of PPE usually develop 1–21 days after higher-dose pulse therapies and up to 2-10 months after continuous low-dose therapies. | *The symptoms of PPE usually develop 1–21 days after higher-dose pulse therapies and up to 2-10 months after continuous low-dose therapies. | ||
*PPE appears to be dose-dependent. | *PPE appears to be dose-dependent. | ||
*Both | *Both peak drug concentration and total cumulative dose determine its occurrence since both bolus infusions and continuous low-dose administration can cause a dose-dependent drug reaction <ref name="pmid3977204">{{cite journal| author=Baer MR, King LE, Wolff SN| title=Palmar-plantar erythrodysesthesia and cytarabine. | journal=Ann Intern Med | year= 1985 | volume= 102 | issue= 4 | pages= 556 | pmid=3977204 | doi=10.7326/0003-4819-102-4-556_1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3977204 }} </ref> <ref name="pmid2926468">{{cite journal| author=Lokich JJ, Ahlgren JD, Gullo JJ, Philips JA, Fryer JG| title=A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program Study. | journal=J Clin Oncol | year= 1989 | volume= 7 | issue= 4 | pages= 425-32 | pmid=2926468 | doi=10.1200/JCO.1989.7.4.425 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2926468 }} </ref><ref name="pmid6223674">{{cite journal| author=Herzig RH, Wolff SN, Lazarus HM, Phillips GL, Karanes C, Herzig GP| title=High-dose cytosine arabinoside therapy for refractory leukemia. | journal=Blood | year= 1983 | volume= 62 | issue= 2 | pages= 361-9 | pmid=6223674 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6223674 }} </ref> <ref name="pmid2528937">{{cite journal| author=Kroll SS, Koller CA, Kaled S, Dreizen S| title=Chemotherapy-induced acral erythema: desquamating lesions involving the hands and feet. | journal=Ann Plast Surg | year= 1989 | volume= 23 | issue= 3 | pages= 263-5 | pmid=2528937 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2528937 }} </ref> | ||
*In addition, combined administration of two chemotherapy drug which both can cause PPE usually results in an increase in the frequency and severity of PPE. | *In addition, combined administration of two chemotherapy drug which both can cause PPE usually results in an increase in the frequency and severity of PPE. | ||
===Complications=== | ===Complications=== | ||
* PPE is not life threatening | * PPE is not life threatening, but it can be very debilitating and impair quality of life. | ||
===Prognosis=== | ===Prognosis=== | ||
Line 32: | Line 25: | ||
* Symptoms usually resolve within 1–2 weeks after stopping the causative chemotherapeutic agent. | * Symptoms usually resolve within 1–2 weeks after stopping the causative chemotherapeutic agent. | ||
* Re-exposure to the causative agent with similar dosage has resulted in the reaction to reoccur in the majority but not all patients.<ref name="pmid2817635">{{cite journal| author=Curran CF, Luce JK| title=Fluorouracil and palmar-plantar erythrodysesthesia. | journal=Ann Intern Med | year= 1989 | volume= 111 | issue= 10 | pages= 858 | pmid=2817635 | doi=10.7326/0003-4819-111-10-858_1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2817635 }} </ref> <ref name="pmid9329890">{{cite journal| author=Demirçay Z, Gürbüz O, Alpdoğan TB, Yücelten D, Alpdoğan O, Kurtkaya O et al.| title=Chemotherapy-induced acral erythema in leukemic patients: a report of 15 cases. | journal=Int J Dermatol | year= 1997 | volume= 36 | issue= 8 | pages= 593-8 | pmid=9329890 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9329890 }} </ref><ref name="pmid6497196">{{cite journal| author=Lokich JJ, Moore C| title=Chemotherapy-associated palmar-plantar erythrodysesthesia syndrome. | journal=Ann Intern Med | year= 1984 | volume= 101 | issue= 6 | pages= 798-9 | pmid=6497196 | doi=10.7326/0003-4819-101-6-798 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6497196 }} </ref> <ref name="pmid4051360">{{cite journal| author=Peters WG, Willemze R| title=Palmar-plantar skin changes and cytarabine. | journal=Ann Intern Med | year= 1985 | volume= 103 | issue= 5 | pages= 805 | pmid=4051360 | doi=10.7326/0003-4819-103-5-805_1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4051360 }} </ref> | * Re-exposure to the causative agent with similar dosage has resulted in the reaction to reoccur in the majority but not all patients.<ref name="pmid2817635">{{cite journal| author=Curran CF, Luce JK| title=Fluorouracil and palmar-plantar erythrodysesthesia. | journal=Ann Intern Med | year= 1989 | volume= 111 | issue= 10 | pages= 858 | pmid=2817635 | doi=10.7326/0003-4819-111-10-858_1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2817635 }} </ref> <ref name="pmid9329890">{{cite journal| author=Demirçay Z, Gürbüz O, Alpdoğan TB, Yücelten D, Alpdoğan O, Kurtkaya O et al.| title=Chemotherapy-induced acral erythema in leukemic patients: a report of 15 cases. | journal=Int J Dermatol | year= 1997 | volume= 36 | issue= 8 | pages= 593-8 | pmid=9329890 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9329890 }} </ref><ref name="pmid6497196">{{cite journal| author=Lokich JJ, Moore C| title=Chemotherapy-associated palmar-plantar erythrodysesthesia syndrome. | journal=Ann Intern Med | year= 1984 | volume= 101 | issue= 6 | pages= 798-9 | pmid=6497196 | doi=10.7326/0003-4819-101-6-798 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6497196 }} </ref> <ref name="pmid4051360">{{cite journal| author=Peters WG, Willemze R| title=Palmar-plantar skin changes and cytarabine. | journal=Ann Intern Med | year= 1985 | volume= 103 | issue= 5 | pages= 805 | pmid=4051360 | doi=10.7326/0003-4819-103-5-805_1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4051360 }} </ref> | ||
==References== | ==References== | ||
{{reflist|3}} | {{reflist|3}} |
Revision as of 16:50, 27 June 2019
Palmar plantar erythrodysesthesia Microchapters |
Differentiating Palmar plantar erythrodysesthesia from other Diseases |
---|
Diagnosis |
Treatment |
Palmar plantar erythrodysesthesia natural history, complications, and prognosis On the Web |
American Roentgen Ray Society Images of Palmar plantar erythrodysesthesia natural history, complications, and prognosis |
FDA on Palmar plantar erythrodysesthesia natural history, complications, and prognosis |
CDC on Palmar plantar erythrodysesthesia natural history, complications, and prognosis |
Palmar plantar erythrodysesthesia natural history, complications, and prognosis in the news |
Blogs on Palmar plantar erythrodysesthesia natural history, complications, and prognosis |
Directions to Hospitals Treating Palmar plantar erythrodysesthesia |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mandana Chitsazan, M.D.
Overview
If left untreated, PPE can progress rapidly.
Prognosis is generally good and symptoms usually resolve within 1-2 weeks after stopping the causative chemotherapeutic agent.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of PPE usually develop 1–21 days after higher-dose pulse therapies and up to 2-10 months after continuous low-dose therapies.
- PPE appears to be dose-dependent.
- Both peak drug concentration and total cumulative dose determine its occurrence since both bolus infusions and continuous low-dose administration can cause a dose-dependent drug reaction [1] [2][3] [4]
- In addition, combined administration of two chemotherapy drug which both can cause PPE usually results in an increase in the frequency and severity of PPE.
Complications
- PPE is not life threatening, but it can be very debilitating and impair quality of life.
Prognosis
- If appropriate management is not implemented rapidly, PPE can progress rapidly.
- Symptoms usually resolve within 1–2 weeks after stopping the causative chemotherapeutic agent.
- Re-exposure to the causative agent with similar dosage has resulted in the reaction to reoccur in the majority but not all patients.[5] [6][7] [8]
References
- ↑ Baer MR, King LE, Wolff SN (1985). "Palmar-plantar erythrodysesthesia and cytarabine". Ann Intern Med. 102 (4): 556. doi:10.7326/0003-4819-102-4-556_1. PMID 3977204.
- ↑ Lokich JJ, Ahlgren JD, Gullo JJ, Philips JA, Fryer JG (1989). "A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program Study". J Clin Oncol. 7 (4): 425–32. doi:10.1200/JCO.1989.7.4.425. PMID 2926468.
- ↑ Herzig RH, Wolff SN, Lazarus HM, Phillips GL, Karanes C, Herzig GP (1983). "High-dose cytosine arabinoside therapy for refractory leukemia". Blood. 62 (2): 361–9. PMID 6223674.
- ↑ Kroll SS, Koller CA, Kaled S, Dreizen S (1989). "Chemotherapy-induced acral erythema: desquamating lesions involving the hands and feet". Ann Plast Surg. 23 (3): 263–5. PMID 2528937.
- ↑ Curran CF, Luce JK (1989). "Fluorouracil and palmar-plantar erythrodysesthesia". Ann Intern Med. 111 (10): 858. doi:10.7326/0003-4819-111-10-858_1. PMID 2817635.
- ↑ Demirçay Z, Gürbüz O, Alpdoğan TB, Yücelten D, Alpdoğan O, Kurtkaya O; et al. (1997). "Chemotherapy-induced acral erythema in leukemic patients: a report of 15 cases". Int J Dermatol. 36 (8): 593–8. PMID 9329890.
- ↑ Lokich JJ, Moore C (1984). "Chemotherapy-associated palmar-plantar erythrodysesthesia syndrome". Ann Intern Med. 101 (6): 798–9. doi:10.7326/0003-4819-101-6-798. PMID 6497196.
- ↑ Peters WG, Willemze R (1985). "Palmar-plantar skin changes and cytarabine". Ann Intern Med. 103 (5): 805. doi:10.7326/0003-4819-103-5-805_1. PMID 4051360.