PIK3CG: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS (v470))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform''' is an [[enzyme]] that in humans is encoded by the ''PIK3CG'' [[gene]].
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_PIK3CG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 17eu.
| PDB = {{PDB2|1e7u}}, {{PDB2|1e7v}}, {{PDB2|1e8w}}, {{PDB2|1e8x}}, {{PDB2|1e8y}}, {{PDB2|1e8z}}, {{PDB2|1e90}}, {{PDB2|1he8}}, {{PDB2|2a4z}}, {{PDB2|2a5u}}, {{PDB2|2chw}}, {{PDB2|2chx}}, {{PDB2|2chz}}
| Name = Phosphoinositide-3-kinase, catalytic, gamma polypeptide
| HGNCid = 8978
| Symbol = PIK3CG
| AltSymbols =; PI3K; PI3CG; PI3Kgamma; PIK3
| OMIM = 601232
| ECnumber = 
| Homologene = 68269
| MGIid = 1353576
| GeneAtlas_image1 = PBB_GE_PIK3CG_206370_at_tn.png
| GeneAtlas_image2 = PBB_GE_PIK3CG_206369_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004428 |text = inositol or phosphatidylinositol kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016303 |text = 1-phosphatidylinositol-3-kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046934 |text = phosphatidylinositol-4,5-bisphosphate 3-kinase activity}}
| Component = {{GNF_GO|id=GO:0005942 |text = phosphoinositide 3-kinase complex}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5294
    | Hs_Ensembl = ENSG00000105851
    | Hs_RefseqProtein = NP_002640
    | Hs_RefseqmRNA = NM_002649
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 106292977
    | Hs_GenLoc_end = 106334801
    | Hs_Uniprot = P48736
    | Mm_EntrezGene = 30955
    | Mm_Ensembl = ENSMUSG00000020573
    | Mm_RefseqmRNA = NM_020272
    | Mm_RefseqProtein = NP_064668
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 32758720
    | Mm_GenLoc_end = 32793858
    | Mm_Uniprot = Q24LN5
  }}
}}
'''Phosphoinositide-3-kinase, catalytic, gamma polypeptide''', also known as '''PIK3CG''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.<ref>{{cite web | title = Entrez Gene: PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5294| accessdate = }}</ref>
{{PBB_Summary
 
| section_title =
== Interactions ==
| summary_text = This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.<ref>{{cite web | title = Entrez Gene: PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5294| accessdate = }}</ref>
 
}}
PIK3CG has been shown to [[Protein-protein interaction|interact]] with:
==See also==
* [[BCR gene]],<ref name = pmid9747873>{{cite journal | vauthors = Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J | title = The SH2-containing adapter protein GRB10 interacts with BCR-ABL | journal = Oncogene | volume = 17 | issue = 8 | pages = 941–8 | date = August 1998 | pmid = 9747873 | doi = 10.1038/sj.onc.1202024 }}</ref><ref name = pmid8641358>{{cite journal | vauthors = Salgia R, Sattler M, Pisick E, Li JL, Griffin JD | title = p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl | journal = Exp. Hematol. | volume = 24 | issue = 2 | pages = 310–3 | date = February 1996 | pmid = 8641358 | doi =  }}</ref><ref name = pmid7606002>{{cite journal | vauthors = Skorski T, Kanakaraj P, Nieborowska-Skorska M, Ratajczak MZ, Wen SC, Zon G, Gewirtz AM, Perussia B, Calabretta B | title = Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells | journal = Blood | volume = 86 | issue = 2 | pages = 726–36 | date = July 1995 | pmid = 7606002 | doi =  }}</ref>
* [[KRAS]],<ref name = pmid10542052>{{cite journal | vauthors = Rubio I, Wittig U, Meyer C, Heinze R, Kadereit D, Waldmann H, Downward J, Wetzker R | title = Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma | journal = Eur. J. Biochem. | volume = 266 | issue = 1 | pages = 70–82 | date = November 1999 | pmid = 10542052 | doi =  10.1046/j.1432-1327.1999.00815.x}}</ref>
* [[P110δ|PIK3CD]],<ref name = pmid9113989>{{cite journal | vauthors = Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD | title = P110delta, a novel phosphoinositide 3-kinase in leukocytes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 9 | pages = 4330–5 | date = April 1997 | pmid = 9113989 | pmc = 20722 | doi =  10.1073/pnas.94.9.4330}}</ref>  and
* [[PIK3R5]].<ref name = pmid12507995>{{cite journal | vauthors = Brock C, Schaefer M, Reusch HP, Czupalla C, Michalke M, Spicher K, Schultz G, Nürnberg B | title = Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma | journal = J. Cell Biol. | volume = 160 | issue = 1 | pages = 89–99 | date = January 2003 | pmid = 12507995 | pmc = 2172741 | doi = 10.1083/jcb.200210115 }}</ref>
 
== See also ==
* [[Class I PI 3-kinases]]
* [[Class I PI 3-kinases]]
* [[p87PIKAP]]
* [[p87PIKAP]]


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Alloatti G, Montrucchio G, Lembo G, Hirsch E | title = Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease. | journal = Biochem. Soc. Trans. | volume = 32 | issue = Pt 2 | pages = 383–6 | year = 2004 | pmid = 15046613 | doi = 10.1042/BST0320383 }}
| citations =
* {{cite journal | vauthors = Rommel C, Camps M, Ji H | title = PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? | journal = Nat. Rev. Immunol. | volume = 7 | issue = 3 | pages = 191–201 | year = 2007 | pmid = 17290298 | doi = 10.1038/nri2036 }}
*{{cite journal | author=Alloatti G, Montrucchio G, Lembo G, Hirsch E |title=Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 2 |pages= 383-6 |year= 2004 |pmid= 15046613 |doi= 10.1042/ }}
*{{cite journal | author=Rommel C, Camps M, Ji H |title=PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? |journal=Nat. Rev. Immunol. |volume=7 |issue= 3 |pages= 191-201 |year= 2007 |pmid= 17290298 |doi= 10.1038/nri2036 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=5294}}
[[Category:Cell_signaling]]
 
{{WikiDoc Sources}}
{{DEFAULTSORT:Pik3cg}}
[[Category:Cell signaling]]
 
 
{{gene-7-stub}}

Latest revision as of 00:35, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PIK3CG gene.

Function

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.[1]

Interactions

PIK3CG has been shown to interact with:

See also

References

  1. ↑ "Entrez Gene: PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide".
  2. ↑ Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL". Oncogene. 17 (8): 941–8. doi:10.1038/sj.onc.1202024. PMID 9747873.
  3. ↑ Salgia R, Sattler M, Pisick E, Li JL, Griffin JD (February 1996). "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl". Exp. Hematol. 24 (2): 310–3. PMID 8641358.
  4. ↑ Skorski T, Kanakaraj P, Nieborowska-Skorska M, Ratajczak MZ, Wen SC, Zon G, Gewirtz AM, Perussia B, Calabretta B (July 1995). "Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells". Blood. 86 (2): 726–36. PMID 7606002.
  5. ↑ Rubio I, Wittig U, Meyer C, Heinze R, Kadereit D, Waldmann H, Downward J, Wetzker R (November 1999). "Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma". Eur. J. Biochem. 266 (1): 70–82. doi:10.1046/j.1432-1327.1999.00815.x. PMID 10542052.
  6. ↑ Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD (April 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4330–5. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989.
  7. ↑ Brock C, Schaefer M, Reusch HP, Czupalla C, Michalke M, Spicher K, Schultz G, Nürnberg B (January 2003). "Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma". J. Cell Biol. 160 (1): 89–99. doi:10.1083/jcb.200210115. PMC 2172741. PMID 12507995.

Further reading

  • Alloatti G, Montrucchio G, Lembo G, Hirsch E (2004). "Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease". Biochem. Soc. Trans. 32 (Pt 2): 383–6. doi:10.1042/BST0320383. PMID 15046613.
  • Rommel C, Camps M, Ji H (2007). "PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?". Nat. Rev. Immunol. 7 (3): 191–201. doi:10.1038/nri2036. PMID 17290298.


Retrieved from "https://www.wikidoc.org/index.php?title=PIK3CG&oldid=1421574"