PCI complications: dissection

Percutaneous coronary intervention Microchapters
Home
Patient Information
Overview
Risk Stratification and Benefits of PCI
Preparation of the Patient for PCI
Equipment Used During PCI
Pharmacotherapy to Support PCI
Vascular Closure Devices
Recommendations for Perioperative Management–Timing of Elective Noncardiac Surgery in Patients Treated With PCI and DAPT
Post-PCI Management
Risk Reduction After PCI
Post-PCI follow up
Hybrid coronary revascularization
PCI approaches
PCI Complications
Factors Associated with Complications Vessel Perforation Dissection Distal Embolization No-reflow Coronary Vasospasm Abrupt Closure Access Site Complications Peri-procedure Bleeding Restenosis Renal Failure Thrombocytopenia Late Acquired Stent Malapposition Loss of Side Branch Multiple Complications
PCI in Specific Patients
Cardiogenic Shock Left Main Coronary Artery Disease Refractory Ventricular Arrhythmia Severely Depressed Ventricular Function Sole Remaining Conduit Unprotected Left Main Patient Adjuncts for High Risk PCI
PCI in Specific Lesion Types
Classification of the Lesion The Calcified Lesion The Ostial Lesion The Angulated or Tortuous Lesion The Bifurcation Lesion The Long Lesion The Bridge Lesion Vasospasm The Chronic Total Occlusion The Left Internal Mammary Artery Multivessel Disease Distal Anastomotic Lesions Left Main Intervention The Thrombotic Lesion
PCI complications: dissection On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of PCI complications: dissection All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on PCI complications: dissection
CDC on PCI complications: dissection
PCI complications: dissection in the news
Blogs on PCI complications: dissection
Directions to Hospitals Treating Percutaneous coronary intervention
Risk calculators and risk factors for PCI complications: dissection

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2], Vanessa Cherniauskas, M.D. [3]

Overview

A coronary artery dissection refers to a split or a tear in the wall of the artery which compresses or compromises the lumen of the artery reducing blood flow. Coronary artery dissection occurs rarely in the absence of percutaneous coronary intervention (PCI). The risk of reduced anterograde flow and lumen narrowing is a relatively (< 3%) uncommon complication of PCI. Significant residual dissections are present in approximately 1.7 % of patients undergoing PCI. Intracoronary stent placement is used to stabilize the dissection.

Classification

The National Heart, Lung and Blood Institute (NHLBI) coronary dissection criteria assign according the severity of coronary dissection following PCI, with the prognostic implications of the coronary dissection depending on extension into the media and adventitia, its axial length, presence of contrast staining, and effect on anterograde coronary perfusion.

Difficulties can be present when assessing the angiographic residual lumen in the presence of coronary dissection due to the frame-to-frame lumen diameter changes using two-dimensional imaging; intravascular ultrasound (IVUS) may be more accurate strategy to provide the true circumference lumen dimensions.

In the NHLBI scheme, dissection is defined as an intraluminal filling defect or flap associated with a hazy, ground-glass appearance. This category is sub-classified using the NHLBI (National Heart Lung and Blood Institute) system for grading dissection types:

Type A

• Type A dissections represent radiolucent areas within the coronary lumen during contrast injection, with minimal or no persistence of contrast after dye has cleared.

Type B

• Type B dissections are parallel tracts or double lumen separated by a radiolucent area during contrast injection, with minimal or no persistence after dye clearance.

Type C

• Type C dissections appear angiographically as contrast outside the coronary lumen ("extraluminal cap") with persistence of contrast in the area after clearance of dye from the coronary lumen.

Type D

• Type D dissections represent spiral ("barber shop pole") luminal filling defects, frequently with extensive contrast staining of the vessel.

Shown below are an animated image and a static image depicting coronary artery dissection type D. Outlined in yellow is the spiral luminal filling defect that characterizes type D coronary artery dissection.

Type E

• Type E dissections appear as new, persistent filling defects.
• As proposed by the Coronary Angioplasty Registry, type E dissection may be caused by thrombus.

Type F

• Type F dissections represent those that lead to total occlusion of the coronary artery, without distal anterograde flow.
• As proposed by the Coronary Angioplasty Registry, type F dissection may be caused by thrombus.

Other Associated Definitions/Terms

• Abrupt closure: Obstruction of contrast flow (TIMI 0 or 1) in a dilated segment with previously documented anterograde flow
• Ectasia: A lesion diameter greater than the reference diameter in one or more areas
• Luminal irregularities: Arterial contour that has a “sawtooth pattern” consisting of opacification but not fulfilling the criteria for dissection or intracoronary thrombus
• Intimal flap: A discrete filling defect in apparent continuity with the arterial wall
• Thrombus: Discrete, mobile angiographic filling defect with or without contrast staining
• Length:Measure end-to-end for type B through F dissections
• Staining: Persistence of contrast within the dissection after washout of contrast from the remaining portion of the vessel
• Perforation Localized: Extravasation of contrast confined to the pericardial space immediately surrounding the artery and not associated with clinical tamponade
• Nonlocalized perforation: Extravasation of contrast with a jet not localized to the pericardial space, potentially associated with clinical tamponade
• Side branch loss: 0, 1, or 2 flow in a side branch > 1.5 mm in diameter which previously had TIMI 3 flow
• Distal embolization: Migration of a filling defect or thrombus to distally occlude the target vessel or one of its branches
• Coronary spasm: Transient or permanent narrowing >50% when a <25% stenosis was previously noted

Pathophysiology

The two primary mechanisms accounting for disruption of the coronary vessel wall include barotrauma and guiding catheter dissections. Most coronary dissections occur as a result of percutaneous coronary intervention, but they may also occur either as an extension of an aortic dissection into the right coronary artery, or in the setting of coronary bypass grafting. Spontaneous coronary artery dissection is itself rare.

Histopathological Findings

Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

• 

  Coronary artery: Dissection Secondary to Trauma: Micro low mag H&E large adventitial hemorrhage this is a diagonal branch of the left anterior descending artery caused massive infarct

• 

  Coronary artery: Dissection Secondary to Trauma: Micro low mag H&E completely occluded LAD

Treatment

Coronary stent placement, surgery and anticoagulation would appear to be reasonable treatment modalities. Given the rare nature of the disease, randomized trial data is obviously lacking. Most intra-procedural dissections can be treated promptly with stenting.

Angiography

Click here to view angiography examples of the different types of coronary artery dissection.