PARVB: Difference between revisions

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{{Infobox_gene}}
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'''Beta-parvin''' is a [[protein]] that in humans is encoded by the ''PARVB'' [[gene]].<ref name="pmid10810093">{{cite journal | vauthors = Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W | title = Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics | journal = Genome Res | volume = 10 | issue = 5 | pages = 703–13 |date=Aug 2000 | pmid = 10810093 | pmc = 310876 | doi =10.1101/gr.10.5.703 }}</ref><ref name="pmid11171322">{{cite journal | vauthors = Olski TM, Noegel AA, Korenbaum E | title = Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily | journal = J Cell Sci | volume = 114 | issue = Pt 3 | pages = 525–38 |date=Feb 2001 | pmid = 11171322 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PARVB parvin, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29780| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Parvin, beta
| HGNCid = 14653
| Symbol = PARVB
| AltSymbols =; CGI-56
| OMIM = 608121
| ECnumber =
| Homologene = 8342
| MGIid = 2153063
| GeneAtlas_image1 = PBB_GE_PARVB_37965_at_tn.png
| GeneAtlas_image2 = PBB_GE_PARVB_37966_at_tn.png
| GeneAtlas_image3 = PBB_GE_PARVB_204629_at_tn.png
  | Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 29780
    | Hs_Ensembl = ENSG00000188677
    | Hs_RefseqProtein = NP_001003828
    | Hs_RefseqmRNA = NM_001003828
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 42726506
    | Hs_GenLoc_end = 42896434
    | Hs_Uniprot = Q9HBI1
    | Mm_EntrezGene = 170736
    | Mm_Ensembl =   
    | Mm_RefseqmRNA = XM_001002115
    | Mm_RefseqProtein = XP_001002115
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Parvin, beta''', also known as '''PARVB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PARVB parvin, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29780| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Members of the parvin family, including PARVB, are actin-binding proteins associated with focal contacts.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PARVB parvin, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29780| accessdate = }}</ref>
| summary_text = Members of the parvin family, including PARVB, [[PARVA]] and [[PARVG]], are actin-binding proteins associated with focal contacts.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PARVB parvin, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29780| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal   |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal | author=Lai CH, Chou CY, Ch'ang LY, ''et al.'' |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703-13 |year= 2000 |pmid= 10810093 |doi=  }}
*{{cite journal   |vauthors=Yamaji S, Suzuki A, Sugiyama Y, etal |title=A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. |journal=J. Cell Biol. |volume=153 |issue= 6 |pages= 1251–64 |year= 2001 |pmid= 11402068 |doi=10.1083/jcb.153.6.1251  | pmc=2192033 }}
*{{cite journal  | author=Olski TM, Noegel AA, Korenbaum E |title=Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. |journal=J. Cell. Sci. |volume=114 |issue= Pt 3 |pages= 525-38 |year= 2001 |pmid= 11171322 |doi=  }}
*{{cite journal  | vauthors=Korenbaum E, Olski TM, Noegel AA |title=Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. |journal=Gene |volume=279 |issue= 1 |pages= 69–79 |year= 2002 |pmid= 11722847 |doi=10.1016/S0378-1119(01)00743-0 }}
*{{cite journal  | author=Yamaji S, Suzuki A, Sugiyama Y, ''et al.'' |title=A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. |journal=J. Cell Biol. |volume=153 |issue= 6 |pages= 1251-64 |year= 2001 |pmid= 11402068 |doi=  }}
*{{cite journal   |vauthors=Yamaji S, Suzuki A, Kanamori H, etal |title=Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 5 |pages= 1324–31 |year= 2002 |pmid= 12372433 |doi=10.1016/S0006-291X(02)02381-1 }}
*{{cite journal  | author=Korenbaum E, Olski TM, Noegel AA |title=Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. |journal=Gene |volume=279 |issue= 1 |pages= 69-79 |year= 2002 |pmid= 11722847 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Yamaji S, Suzuki A, Kanamori H, ''et al.'' |title=Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 5 |pages= 1324-31 |year= 2002 |pmid= 12372433 |doi=  }}
*{{cite journal  | vauthors=Rosenberger G, Jantke I, Gal A, Kutsche K |title=Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling. |journal=Hum. Mol. Genet. |volume=12 |issue= 2 |pages= 155–67 |year= 2003 |pmid= 12499396 |doi=10.1093/hmg/ddg019 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Collins JE, Goward ME, Cole CG, etal |title=Reevaluating human gene annotation: a second-generation analysis of chromosome 22. |journal=Genome Res. |volume=13 |issue= 1 |pages= 27–36 |year= 2003 |pmid= 12529303 |doi= 10.1101/gr.695703 | pmc=430954 }}
*{{cite journal  | author=Rosenberger G, Jantke I, Gal A, Kutsche K |title=Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling. |journal=Hum. Mol. Genet. |volume=12 |issue= 2 |pages= 155-67 |year= 2003 |pmid= 12499396 |doi=  }}
*{{cite journal   |vauthors=Mishima W, Suzuki A, Yamaji S, etal |title=The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor. |journal=Genes Cells |volume=9 |issue= 3 |pages= 193–204 |year= 2004 |pmid= 15005707 |doi=10.1111/j.1356-9597.2004.00717.x }}
*{{cite journal | author=Collins JE, Goward ME, Cole CG, ''et al.'' |title=Reevaluating human gene annotation: a second-generation analysis of chromosome 22. |journal=Genome Res. |volume=13 |issue= 1 |pages= 27-36 |year= 2003 |pmid= 12529303 |doi= 10.1101/gr.695703 }}
*{{cite journal   |vauthors=Yamaji S, Suzuki A, Kanamori H, etal |title=Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction. |journal=J. Cell Biol. |volume=165 |issue= 4 |pages= 539–51 |year= 2004 |pmid= 15159419 |doi= 10.1083/jcb.200308141 | pmc=2172344 }}
*{{cite journal | author=Mishima W, Suzuki A, Yamaji S, ''et al.'' |title=The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor. |journal=Genes Cells |volume=9 |issue= 3 |pages= 193-204 |year= 2004 |pmid= 15005707 |doi=  }}
*{{cite journal  | vauthors=Zhang Y, Chen K, Tu Y, Wu C |title=Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. |journal=J. Biol. Chem. |volume=279 |issue= 40 |pages= 41695–705 |year= 2004 |pmid= 15284246 |doi= 10.1074/jbc.M401563200 }}
*{{cite journal | author=Yamaji S, Suzuki A, Kanamori H, ''et al.'' |title=Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction. |journal=J. Cell Biol. |volume=165 |issue= 4 |pages= 539-51 |year= 2004 |pmid= 15159419 |doi= 10.1083/jcb.200308141 }}
*{{cite journal   |vauthors=Mongroo PS, Johnstone CN, Naruszewicz I, etal |title=Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer. |journal=Oncogene |volume=23 |issue= 55 |pages= 8959–70 |year= 2004 |pmid= 15467740 |doi= 10.1038/sj.onc.1208112 }}
*{{cite journal  | author=Zhang Y, Chen K, Tu Y, Wu C |title=Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. |journal=J. Biol. Chem. |volume=279 |issue= 40 |pages= 41695-705 |year= 2004 |pmid= 15284246 |doi= 10.1074/jbc.M401563200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Mongroo PS, Johnstone CN, Naruszewicz I, ''et al.'' |title=Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer. |journal=Oncogene |volume=23 |issue= 55 |pages= 8959-70 |year= 2004 |pmid= 15467740 |doi= 10.1038/sj.onc.1208112 }}
*{{cite journal   |vauthors=Matsuda C, Kameyama K, Tagawa K, etal |title=Dysferlin interacts with affixin (beta-parvin) at the sarcolemma. |journal=J. Neuropathol. Exp. Neurol. |volume=64 |issue= 4 |pages= 334–40 |year= 2005 |pmid= 15835269 |doi=  }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Matsuda C, Kameyama K, Tagawa K, ''et al.'' |title=Dysferlin interacts with affixin (beta-parvin) at the sarcolemma. |journal=J. Neuropathol. Exp. Neurol. |volume=64 |issue= 4 |pages= 334-40 |year= 2005 |pmid= 15835269 |doi=  }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 17:34, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Beta-parvin is a protein that in humans is encoded by the PARVB gene.[1][2][3]

Members of the parvin family, including PARVB, PARVA and PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM][3]

References

  1. ↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  2. ↑ Olski TM, Noegel AA, Korenbaum E (Feb 2001). "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily". J Cell Sci. 114 (Pt 3): 525–38. PMID 11171322.
  3. ↑ 3.0 3.1 "Entrez Gene: PARVB parvin, beta".

Further reading



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