NODAL

Nodal homolog (mouse)
Identifiers
Symbols	NODAL ; MGC138230
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8417
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Nodal homolog (mouse), also known as NODAL, is a human gene.

The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development.

Further reading

• Postovit LM, Seftor EA, Seftor RE, Hendrix MJ (2007). "Targeting Nodal in malignant melanoma cells". Expert Opin. Ther. Targets. 11 (4): 497–505. doi:10.1517/14728222.11.4.497. PMID 17373879.CS1 maint: Multiple names: authors list (link)
• Zhou X, Sasaki H, Lowe L; et al. (1993). "Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation". Nature. 361 (6412): 543–7. doi:10.1038/361543a0. PMID 8429908.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gebbia M, Ferrero GB, Pilia G; et al. (1997). "X-linked situs abnormalities result from mutations in ZIC3". Nat. Genet. 17 (3): 305–8. doi:10.1038/ng1197-305. PMID 9354794.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yan YT, Liu JJ, Luo Y; et al. (2002). "Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway". Mol. Cell. Biol. 22 (13): 4439–49. PMID 12052855.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roberts HJ, Hu S, Qiu Q; et al. (2003). "Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta". Biol. Reprod. 68 (5): 1719–26. doi:10.1095/biolreprod.102.013045. PMID 12606401.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Munir S, Xu G, Wu Y; et al. (2004). "Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells". J. Biol. Chem. 279 (30): 31277–86. doi:10.1074/jbc.M400641200. PMID 15150278.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Haffner C, Frauli M, Topp S; et al. (2005). "Nicalin and its binding partner Nomo are novel Nodal signaling antagonists". EMBO J. 23 (15): 3041–50. doi:10.1038/sj.emboj.7600307. PMID 15257293.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Besser D (2004). "Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3". J. Biol. Chem. 279 (43): 45076–84. doi:10.1074/jbc.M404979200. PMID 15308665.
• Bamforth SD, Bragança J, Farthing CR; et al. (2004). "Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway". Nat. Genet. 36 (11): 1189–96. doi:10.1038/ng1446. PMID 15475956.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vallier L, Reynolds D, Pedersen RA (2005). "Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway". Dev. Biol. 275 (2): 403–21. doi:10.1016/j.ydbio.2004.08.031. PMID 15501227.CS1 maint: Multiple names: authors list (link)
• Hart AH, Willson TA, Wong M; et al. (2005). "Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1". Biochem. Biophys. Res. Commun. 333 (4): 1361–9. doi:10.1016/j.bbrc.2005.06.044. PMID 15982639.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vallier L, Alexander M, Pedersen RA (2006). "Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells". J. Cell. Sci. 118 (Pt 19): 4495–509. doi:10.1242/jcs.02553. PMID 16179608.CS1 maint: Multiple names: authors list (link)