Multiple sclerosis pathophysiology: Difference between revisions
No edit summary |
No edit summary |
||
Line 12: | Line 12: | ||
== Pathophysiology == | == Pathophysiology == | ||
Multiple sclerosis is a disease of central nervous system and it’s known to be multifactorial. There are both inflammation and degeneration in the course of the disease but as its progress, degeneration becomes more prominent.<ref name="pmid23762311">{{cite journal |vauthors=Fiorini A, Koudriavtseva T, Bucaj E, Coccia R, Foppoli C, Giorgi A, Schininà ME, Di Domenico F, De Marco F, Perluigi M |title=Involvement of oxidative stress in occurrence of relapses in multiple sclerosis: the spectrum of oxidatively modified serum proteins detected by proteomics and redox proteomics analysis |journal=PLoS ONE |volume=8 |issue=6 |pages=e65184 |year=2013 |pmid=23762311 |pmc=3676399 |doi=10.1371/journal.pone.0065184 |url=}}</ref> | Multiple sclerosis is a [[disease]] of [[central nervous system]] and it’s known to be multifactorial. There are both [[inflammation]] and [[degeneration]] in the course of the [[disease]] but as its progress, [[degeneration]] becomes more prominent.<ref name="pmid23762311">{{cite journal |vauthors=Fiorini A, Koudriavtseva T, Bucaj E, Coccia R, Foppoli C, Giorgi A, Schininà ME, Di Domenico F, De Marco F, Perluigi M |title=Involvement of oxidative stress in occurrence of relapses in multiple sclerosis: the spectrum of oxidatively modified serum proteins detected by proteomics and redox proteomics analysis |journal=PLoS ONE |volume=8 |issue=6 |pages=e65184 |year=2013 |pmid=23762311 |pmc=3676399 |doi=10.1371/journal.pone.0065184 |url=}}</ref> Whatever the trigger is, it will lead to acquired [[immune response]] followed by [[Inflammation|inflammatory]] reactions. This reactions lead to secretion of [[cytokines]] in [[CNS]] [[parenchyma]] and activation of resident [[microglia]]. [[Microglia]] cells activate [[astrocytes]] to release more [[Inflammation|inflammatory]] [[cytokines]] leading to recruitment and [[Infiltration (medical)|infiltration]] of circulatory [[leukocytes]]. | ||
==References== | ==References== |
Revision as of 08:40, 24 January 2018
https://https://www.youtube.com/watch?v=yzH8ul5PSZ8 |350}} |
Multiple sclerosis Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Multiple sclerosis pathophysiology On the Web |
American Roentgen Ray Society Images of Multiple sclerosis pathophysiology |
Risk calculators and risk factors for Multiple sclerosis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Multiple sclerosis is a disease of central nervous system and it’s known to be multifactorial. There are both inflammation and degeneration in the course of the disease but as its progress, degeneration becomes more prominent.[1] Whatever the trigger is, it will lead to acquired immune response followed by inflammatory reactions. This reactions lead to secretion of cytokines in CNS parenchyma and activation of resident microglia. Microglia cells activate astrocytes to release more inflammatory cytokines leading to recruitment and infiltration of circulatory leukocytes.
References
- ↑ Fiorini A, Koudriavtseva T, Bucaj E, Coccia R, Foppoli C, Giorgi A, Schininà ME, Di Domenico F, De Marco F, Perluigi M (2013). "Involvement of oxidative stress in occurrence of relapses in multiple sclerosis: the spectrum of oxidatively modified serum proteins detected by proteomics and redox proteomics analysis". PLoS ONE. 8 (6): e65184. doi:10.1371/journal.pone.0065184. PMC 3676399. PMID 23762311.