Multiple myeloma other imaging findings: Difference between revisions
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==Overview== | ==Overview== | ||
[[Positron | [[Positron emission tomography]] (PET) scan may be diagnostic of multiple myeloma.<ref name="C">Diagnosing multiple myeloma. Canadian Cancer Society (2015) http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/diagnosis/?region=mb#blood_chem Accessed on September, 20th 2015</ref><ref name="r">Multiple myeloma. Radiopaedia (2015)http://radiopaedia.org/articles/multiple-myeloma-1 Accessed on September, 20th 2015</ref><ref name="pmid19304704">{{cite journal| author=Shortt CP, Gleeson TG, Breen KA, McHugh J, O'Connell MJ, O'Gorman PJ et al.| title=Whole-Body MRI versus PET in assessment of multiple myeloma disease activity. | journal=AJR Am J Roentgenol | year= 2009 | volume= 192 | issue= 4 | pages= 980-6 | pmid=19304704 | doi=10.2214/AJR.08.1633 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19304704 }} </ref><ref name="pmid23521465">{{cite journal| author=Agarwal A, Chirindel A, Shah BA, Subramaniam RM| title=Evolving role of FDG PET/CT in multiple myeloma imaging and management. | journal=AJR Am J Roentgenol | year= 2013 | volume= 200 | issue= 4 | pages= 884-90 | pmid=23521465 | doi=10.2214/AJR.12.9653 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23521465 }} </ref><ref name="pmid27476706">{{cite journal |vauthors=Gerecke C, Fuhrmann S, Strifler S, Schmidt-Hieber M, Einsele H, Knop S |title=The Diagnosis and Treatment of Multiple Myeloma |journal=Dtsch Arztebl Int |volume=113 |issue=27-28 |pages=470–6 |date=July 2016 |pmid=27476706 |pmc=4973001 |doi=10.3238/arztebl.2016.0470 |url=}}</ref>Findings on PET scan suggestive of multiple myeloma include uptake of the F18-FDG molecule by lesions of bone lysis seen on PET-CT scan.<ref name="r">Multiple myeloma. Radiopaedia (2015)http://radiopaedia.org/articles/multiple-myeloma-1 Accessed on September, 20th 2015</ref><ref name="pmid27476706">{{cite journal |vauthors=Gerecke C, Fuhrmann S, Strifler S, Schmidt-Hieber M, Einsele H, Knop S |title=The Diagnosis and Treatment of Multiple Myeloma |journal=Dtsch Arztebl Int |volume=113 |issue=27-28 |pages=470–6 |date=July 2016 |pmid=27476706 |pmc=4973001 |doi=10.3238/arztebl.2016.0470 |url=}}</ref> | ||
==Positron Emission Tomography Scan== | ==Positron Emission Tomography Scan== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Shyam Patel [3]
Overview
Positron emission tomography (PET) scan may be diagnostic of multiple myeloma.[1][2][3][4][5]Findings on PET scan suggestive of multiple myeloma include uptake of the F18-FDG molecule by lesions of bone lysis seen on PET-CT scan.[2][5]
Positron Emission Tomography Scan
- Positron emission tomography (PET) scan is a highly sensitive and specific diagnostic tool for diagnosing multiple myeloma.[3][4][5]
- Uptake of the F18-FDG molecule by lesions of multiple myeloma corresponds to areas of bone lysis seen on PET-CT scan.[2][5]
- PET scan is superior to either CT scan or X-ray for diagnosis of lytic lesions of multiple myeloma.[3][4][1]
- PET scan is useful in the detection of cancer spread to distant lymph nodes.[3][4]
- PET can assess for spleen involvement more readily than other imaging modalities.
- The use of PET scan has led to earlier diagnosis of multiple myeloma and increased the accuracy of therapy response assessment.[6]
- PET scan has still not been employed as a standard of care by the International Myeloma Working Group.[6]
References
- ↑ 1.0 1.1 Diagnosing multiple myeloma. Canadian Cancer Society (2015) http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/diagnosis/?region=mb#blood_chem Accessed on September, 20th 2015
- ↑ 2.0 2.1 2.2 Multiple myeloma. Radiopaedia (2015)http://radiopaedia.org/articles/multiple-myeloma-1 Accessed on September, 20th 2015
- ↑ 3.0 3.1 3.2 3.3 Shortt CP, Gleeson TG, Breen KA, McHugh J, O'Connell MJ, O'Gorman PJ; et al. (2009). "Whole-Body MRI versus PET in assessment of multiple myeloma disease activity". AJR Am J Roentgenol. 192 (4): 980–6. doi:10.2214/AJR.08.1633. PMID 19304704.
- ↑ 4.0 4.1 4.2 4.3 Agarwal A, Chirindel A, Shah BA, Subramaniam RM (2013). "Evolving role of FDG PET/CT in multiple myeloma imaging and management". AJR Am J Roentgenol. 200 (4): 884–90. doi:10.2214/AJR.12.9653. PMID 23521465.
- ↑ 5.0 5.1 5.2 5.3 Gerecke C, Fuhrmann S, Strifler S, Schmidt-Hieber M, Einsele H, Knop S (July 2016). "The Diagnosis and Treatment of Multiple Myeloma". Dtsch Arztebl Int. 113 (27–28): 470–6. doi:10.3238/arztebl.2016.0470. PMC 4973001. PMID 27476706.
- ↑ 6.0 6.1 Dimopoulos M, Terpos E, Comenzo RL, Tosi P, Beksac M, Sezer O; et al. (2009). "International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple Myeloma". Leukemia. 23 (9): 1545–56. doi:10.1038/leu.2009.89. PMID 19421229.