Multiple myeloma history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The signs and symptoms of multiple myeloma are most commonly associated with either elevation in calcium concentrations, renal failure, anemia and involvement of the bones such as fractures and pains.

History and Symptoms

Early multiple myeloma does not have any symptoms. In as many as 30-40% cases the diagnosis may be incidental and is often diagnosed on routine blood screening. A rise in total protein levels without a concomitant rise in albumin levels must make the physician suspicious for a possibility of multiple myeloma. As the tumor grows larger, people may notice one or more of the following symptoms:

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