Multiple myeloma history and symptoms: Difference between revisions

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:*[[Bone pain]]
:*[[Bone pain]]
::*Usually involves the spine and ribs, and worsens with activity.
::*Usually involves the spine and ribs, and worsens with activity
::*Persistent localized pain may indicate a pathological [[bone fracture]]
::*Persistent localized pain may indicate a pathological [[bone fracture]]
:*Neurological symptoms
:*Neurological symptoms

Revision as of 12:30, 23 September 2015

Multiple myeloma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

The most common symptoms of multiple myeloma include bone pain, pallor, and fatigue.[1][2][3] However, the presenting symptoms of multiple myeloma may vary greatly due to involvement of many organ systems. The common symptoms of multiple myeloma can be remembered by the mnemonic CRAB - C = Calcium (elevated), R = Renal failure, A = Anemia, B = Bone lesions.[4][5][6]

History

  • When evaluating a patient for multiple myeloma, you should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and a thorough medication review. Other specific areas of focus when obtaining the history are outlined below:[7]
    • Review past medical history for other plasma cell diseases
    • Review family history for members with positive history of the disease
    • Review occupational history related to farming or oil industry
    • Review any exposure to radiation or toxic chemicals

Common Symptoms

Symptoms of multiple myeloma include:[8][9][10]

  • Usually involves the spine and ribs, and worsens with activity
  • Persistent localized pain may indicate a pathological bone fracture
  • Neurological symptoms
  • Bone marrow failure related symptoms
  • Easy bruising, nosebleeds, bleeding gums due to thrombocytopenia
  • Fatigue, weakness, shortness of breath, dizziness and paleness due to anemia
  • Recurrent infections due to decreased white blood cell count.
  • Lower limb edema due to renal involvement

References

  1. Multiple myeloma. Wikipedia (2015) https://en.wikipedia.org/wiki/Multiple_myeloma#Signs_and_symptoms Accessed on September, 20th 2015
  2. Multiple myeloma. Canadian Cancer Society (2015) http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/signs-and-symptoms/?region=mb Accessed on September 20th 2015
  3. Multiple myeloma. Cancer. gov(2015) http://www.cancer.gov/types/myeloma Accessed on September, 20th 2015
  4. International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003;121:749-57. PMID 12780789.
  5. Multiple myeloma. Canadian Cancer Society (2015) http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/signs-and-symptoms/?region=mb Accessed on September 20th 2015
  6. Multiple myeloma. Cancer. gov(2015) http://www.cancer.gov/types/myeloma Accessed on September, 20th 2015
  7. Multiple myeloma. MedlinePlus (2015)http://www.wikidoc.org/index.php?title=Multiple_myeloma_risk_factors&action=edit&section=2 Accessed on Septmeber, 20th 2015
  8. Multiple myeloma. Wikipedia (2015) https://en.wikipedia.org/wiki/Multiple_myeloma#Signs_and_symptoms Accessed on September, 20th 2015
  9. Multiple myeloma. Canadian Cancer Society (2015) http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/signs-and-symptoms/?region=mb Accessed on September 20th 2015
  10. Multiple myeloma. Cancer. gov(2015) http://www.cancer.gov/types/myeloma Accessed on September, 20th 2015


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