Multiple myeloma history and symptoms: Difference between revisions
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==History== | ==History== | ||
* When evaluating a patient for multiple myeloma, you should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and a thorough medication review. Other specific areas of focus when obtaining the history | * When evaluating a patient for multiple myeloma, you should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and a thorough medication review. Other specific areas of focus when obtaining the history are outlined below: :<ref>Multiple myeloma. MedlinePlus (2015)http://www.wikidoc.org/index.php?title=Multiple_myeloma_risk_factors&action=edit§ion=2 Accessed on Septmeber, 20th 2015 </ref> | ||
**Reviewing past medical history for other plasma cell diseases. | **Reviewing past medical history for other plasma cell diseases. | ||
**Reviewing family history for any family member with positive history of the disease. | **Reviewing family history for any family member with positive history of the disease. | ||
Revision as of 13:28, 21 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The most common symptoms of multiple myeloma include fatigue, pallor, and bone pain.[1] However, the presenting symptoms of multiple myeloma may vary greatly due to involvement of many organ systems. The common symptoms of multiple myeloma can be remembered by the mnemonic CRAB - C = Calcium (elevated), R =Renal failure, A = Anemia, B = Bone lesions.[2]
History
- When evaluating a patient for multiple myeloma, you should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and a thorough medication review. Other specific areas of focus when obtaining the history are outlined below: :[3]
- Reviewing past medical history for other plasma cell diseases.
- Reviewing family history for any family member with positive history of the disease.
- Review any occupational history related to farming or oil industry.
- Review any exposure to petroleum, radiation, or toxic chemicals.
Common Symptoms
Symptoms of multiple myeloma include:[4]
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- Usually involves the spine and ribs, and worsens with activity.
- Persistent localized pain may indicate a pathological bone fracture
- Neurological symptoms
- Numbness
- muscle weakness
- Confusion
- Dizziness
- Headache
- visual changes
- Hypercalcemia related symptmos
- Polyurea
- Polydypsia
- Constipation
- Bone marrow failure related symptoms
- Bleeding
- easy bruising
- Lower limb edema due to renal involvement.
- Recurrent infections
References
- ↑ Multiple myeloma. Wikipedia (2015) https://en.wikipedia.org/wiki/Multiple_myeloma#Signs_and_symptoms Accessed on September, 20th 2015
- ↑ International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003;121:749-57. PMID 12780789.
- ↑ Multiple myeloma. MedlinePlus (2015)http://www.wikidoc.org/index.php?title=Multiple_myeloma_risk_factors&action=edit§ion=2 Accessed on Septmeber, 20th 2015
- ↑ Multiple myeloma. Wikipedia (2015) https://en.wikipedia.org/wiki/Multiple_myeloma#Signs_and_symptoms Accessed on September, 20th 2015