Multiple myeloma history and symptoms: Difference between revisions

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==History==
==History==
*Early multiple myeloma does not have any symptoms.
* When evaluating a patient for multiple myeloma, you should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and medication review. Other specific areas of focus when obtaining the history, are outlined below: :<ref>Multiple myeloma. MedlinePlus (2015)http://www.wikidoc.org/index.php?title=Multiple_myeloma_risk_factors&action=edit&section=2 Accessed on Septmeber, 20th 2015 </ref>
*In as many as 30-40% cases the diagnosis may be incidental and is often diagnosed on routine blood screening.
**Reviewing past medical history for other plasma cell diseases.
**Reviewing family history for any positive family member.
**Review occupational history related to farming or oil industry.
**Review any exposure to petroleum, radiation, or toxic chemicals.
 
*A rise in total protein levels without a concomitant rise in albumin levels must make the physician suspicious for a possibility of multiple myeloma.
*A rise in total protein levels without a concomitant rise in albumin levels must make the physician suspicious for a possibility of multiple myeloma.
*As the tumor grows larger people may notice one or more of the symptoms.
 
==Common Symptoms==  
==Common Symptoms==  
Symptoms of multiple myeloma include:<ref>Multiple myeloma. Wikipedia (2015) https://en.wikipedia.org/wiki/Multiple_myeloma#Signs_and_symptoms Accessed on September, 20th 2015</ref>
Symptoms of multiple myeloma include:<ref>Multiple myeloma. Wikipedia (2015) https://en.wikipedia.org/wiki/Multiple_myeloma#Signs_and_symptoms Accessed on September, 20th 2015</ref>

Revision as of 15:56, 20 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The most common symptoms of multiple myeloma include fatigue, pallor, and bone pain.[1] However, the presenting symptoms of multiple myeloma may vary greatly due to involvement of many organ systems. The common symptoms of multiple myeloma can be remembered by the mnemonic CRAB - C = Calcium (elevated), R =Renal failure, A = Anemia, B = Bone lesions.[2]

History

  • When evaluating a patient for multiple myeloma, you should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and medication review. Other specific areas of focus when obtaining the history, are outlined below: :[3]
    • Reviewing past medical history for other plasma cell diseases.
    • Reviewing family history for any positive family member.
    • Review occupational history related to farming or oil industry.
    • Review any exposure to petroleum, radiation, or toxic chemicals.
  • A rise in total protein levels without a concomitant rise in albumin levels must make the physician suspicious for a possibility of multiple myeloma.

Common Symptoms

Symptoms of multiple myeloma include:[4]

  • Usually involves the spine and ribs, and worsens with activity.
  • Persistent localized pain may indicate a pathological bone fracture
  • Neurological symptoms
  • Hypercalcemia
  • Polyurea
  • Polydypsia
  • Constipation
  • Bleeding
  • Recurrent infections

References

  1. ↑ Multiple myeloma. Wikipedia (2015) https://en.wikipedia.org/wiki/Multiple_myeloma#Signs_and_symptoms Accessed on September, 20th 2015
  2. ↑ International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003;121:749-57. PMID 12780789.
  3. ↑ Multiple myeloma. MedlinePlus (2015)http://www.wikidoc.org/index.php?title=Multiple_myeloma_risk_factors&action=edit&section=2 Accessed on Septmeber, 20th 2015
  4. ↑ Multiple myeloma. Wikipedia (2015) https://en.wikipedia.org/wiki/Multiple_myeloma#Signs_and_symptoms Accessed on September, 20th 2015


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