Multiple myeloma CT: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Multiple myeloma}} | {{Multiple myeloma}} | ||
{{CMG}} {{AE}} {{HMHJ}} | {{CMG}} {{AE}} {{HMHJ}}; {{HL}}; {{shyam}} | ||
==Overview== | ==Overview== | ||
[[CT scan]] does not have a major role in the [[diagnosis]] of disseminated [[multiple myeloma]] | [[CT scan]] does not have a major role in the [[diagnosis]] of disseminated [[multiple myeloma]] but low-dose whole-body [[Computed tomography|CT]] may be helpful. [[CT-scans|CT]] scan may also be useful for [[diagnosis]] of [[Thrombosis|thrombotic]]-related [[complications]] and [[Bone|bony]] destruction from [[multiple myeloma]]. [[CT]] carries a high risk for [[radiation]] and should not be performed in [[pregnant]] [[patients]]. | ||
==CT Scan== | ==CT Scan== | ||
*[[CT scan]] does not have a major role in the [[diagnosis]] of disseminated [[multiple myeloma]] but low-dose whole-body [[CT]] may be helpful.<ref name="l">Multiple myeloma. Radiopaedia (2015)http://radiopaedia.org/articles/multiple-myeloma-1 Accessed on September, 20th 2015</ref><ref name="pmid27476706">{{cite journal |vauthors=Gerecke C, Fuhrmann S, Strifler S, Schmidt-Hieber M, Einsele H, Knop S |title=The Diagnosis and Treatment of Multiple Myeloma |journal=Dtsch Arztebl Int |volume=113 |issue=27-28 |pages=470–6 |date=July 2016 |pmid=27476706 |pmc=4973001 |doi=10.3238/arztebl.2016.0470 |url=}}</ref><ref name="pmid24614435">{{cite journal |vauthors=Reisenbuckler C |title=Multiple myeloma and diagnostic imaging |journal=Radiol Technol |volume=85 |issue=4 |pages=391–410; quiz 411–3 |date=2014 |pmid=24614435 |doi= |url=}}</ref> | *[[CT scan]] does not have a major role in the [[diagnosis]] of disseminated [[multiple myeloma]] but low-dose whole-body [[CT]] may be helpful.<ref name="l">Multiple myeloma. Radiopaedia (2015)http://radiopaedia.org/articles/multiple-myeloma-1 Accessed on September, 20th 2015</ref><ref name="pmid27476706">{{cite journal |vauthors=Gerecke C, Fuhrmann S, Strifler S, Schmidt-Hieber M, Einsele H, Knop S |title=The Diagnosis and Treatment of Multiple Myeloma |journal=Dtsch Arztebl Int |volume=113 |issue=27-28 |pages=470–6 |date=July 2016 |pmid=27476706 |pmc=4973001 |doi=10.3238/arztebl.2016.0470 |url=}}</ref><ref name="pmid24614435">{{cite journal |vauthors=Reisenbuckler C |title=Multiple myeloma and diagnostic imaging |journal=Radiol Technol |volume=85 |issue=4 |pages=391–410; quiz 411–3 |date=2014 |pmid=24614435 |doi= |url=}}</ref> | ||
*[[CT scan]] in combination with [[PET|PET imaging]] is highly useful for the [[diagnosis]] of [[osseous]] [[Lesion|lesions]]. [[Osseous]] | *[[CT scan]] in combination with [[PET|PET imaging]] is highly useful for the [[diagnosis]] of [[osseous]] [[Lesion|lesions]]. [[Osseous]] lytic lesions will be [[fluorodeoxyglucose]] (FDG)-avid ([[hypermetabolic]]) on [[Positron emission tomography|PET]]/[[CT-scans|CT]]. [[Positron emission tomography|PET]]/[[CT]] is very sensitive for the [[diagnosis]] of [[lytic]] [[lesions]] of [[multiple myeloma]]. | ||
*[[CT scan]] may be useful in the detection of [[Thrombosis|thrombotic]] [[complications]] related to [[multiple myeloma]], including [[pulmonary embolism]] or [[mesenteric]] venous [[thrombosis]]. | *[[CT scan]] may be useful in the detection of [[Thrombosis|thrombotic]] [[complications]] related to [[multiple myeloma]], including [[pulmonary embolism]] or [[mesenteric]] venous [[thrombosis]]. | ||
*[[CT scan]] may be useful to determine the extent of extra-[[osseous]] [[soft tissue]] component ([[plasmacytoma]]) in [[patients]] with a large [[disease]] burden. | *[[CT scan]] may be useful to determine the extent of extra-[[osseous]] [[soft tissue]] component ([[plasmacytoma]]) in [[patients]] with a large [[disease]] burden. | ||
*Contrast [[CT scan]] may lead to [[renal failure]] in [[multiple myeloma]] more frequently than otherwise. Hence, other modalities are preferred over [[CT scan]] for [[patients]] with [[multiple myeloma]]. | *Contrast [[CT scan]] may lead to [[renal failure]] in [[multiple myeloma]] more frequently than otherwise. Hence, other modalities are preferred over [[CT scan]] for [[patients]] with [[multiple myeloma]]. | ||
*[[CT scan]] carries a high risk for [[radiation]] exposure and subsequent [[malignancies]]. In contrast, [[MRI]] carries no [[radiation]] risk, and [[MRI]] may thus be more appropriate for some [[patients]]. | *[[CT scan]] carries a high risk for [[radiation]] exposure and subsequent [[malignancies]]. In contrast, [[MRI]] carries no [[radiation]] risk, and [[MRI]] may thus be more appropriate for some [[patients]]. | ||
*[[CT scan]] is less expensive than [[MRI]] but more expensive than [[X-ray]]. Clinical judgement should be used when decided which [[imaging]] modality to use. | *[[CT scan]] is less expensive than [[MRI]] but more expensive than [[X-ray]]. Clinical judgement should be used when decided which [[imaging]] modality to use. | ||
*[[CT scan]] should not be done in [[pregnant]] [[patients]] with [[multiple myeloma]], given the risk of [[radiation]] exposure. Instead, [[MRI]] can be done. | *[[CT scan]] should not be done in [[pregnant]] [[patients]] with [[multiple myeloma]], given the risk of [[radiation]] exposure. Instead, [[MRI]] can be done. | ||
==References== | ==References== | ||
{{ | {{Reflist|2}} | ||
[[Category: | [[Category:Medicine]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Neurology]] | [[Category:Neurology]] | ||
[[Category:Neurosurgery]] | [[Category:Neurosurgery]] | ||
[[Category:Oncology]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Surgery]] | |||
Latest revision as of 22:46, 29 July 2020
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Multiple myeloma Microchapters |
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Multiple myeloma CT On the Web |
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American Roentgen Ray Society Images of Multiple myeloma CT |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Hannan Javed, M.D.[2]; Haytham Allaham, M.D. [3]; Shyam Patel [4]
Overview
CT scan does not have a major role in the diagnosis of disseminated multiple myeloma but low-dose whole-body CT may be helpful. CT scan may also be useful for diagnosis of thrombotic-related complications and bony destruction from multiple myeloma. CT carries a high risk for radiation and should not be performed in pregnant patients.
CT Scan
- CT scan does not have a major role in the diagnosis of disseminated multiple myeloma but low-dose whole-body CT may be helpful.[1][2][3]
- CT scan in combination with PET imaging is highly useful for the diagnosis of osseous lesions. Osseous lytic lesions will be fluorodeoxyglucose (FDG)-avid (hypermetabolic) on PET/CT. PET/CT is very sensitive for the diagnosis of lytic lesions of multiple myeloma.
- CT scan may be useful in the detection of thrombotic complications related to multiple myeloma, including pulmonary embolism or mesenteric venous thrombosis.
- CT scan may be useful to determine the extent of extra-osseous soft tissue component (plasmacytoma) in patients with a large disease burden.
- Contrast CT scan may lead to renal failure in multiple myeloma more frequently than otherwise. Hence, other modalities are preferred over CT scan for patients with multiple myeloma.
- CT scan carries a high risk for radiation exposure and subsequent malignancies. In contrast, MRI carries no radiation risk, and MRI may thus be more appropriate for some patients.
- CT scan is less expensive than MRI but more expensive than X-ray. Clinical judgement should be used when decided which imaging modality to use.
- CT scan should not be done in pregnant patients with multiple myeloma, given the risk of radiation exposure. Instead, MRI can be done.
References
- ↑ Multiple myeloma. Radiopaedia (2015)http://radiopaedia.org/articles/multiple-myeloma-1 Accessed on September, 20th 2015
- ↑ Gerecke C, Fuhrmann S, Strifler S, Schmidt-Hieber M, Einsele H, Knop S (July 2016). "The Diagnosis and Treatment of Multiple Myeloma". Dtsch Arztebl Int. 113 (27–28): 470–6. doi:10.3238/arztebl.2016.0470. PMC 4973001. PMID 27476706.
- ↑ Reisenbuckler C (2014). "Multiple myeloma and diagnostic imaging". Radiol Technol. 85 (4): 391–410, quiz 411–3. PMID 24614435.