Mucoepidermoid carcinoma natural history: Difference between revisions

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__NOTOC__
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{{Mucoepidermoid carcinoma}}
{{Mucoepidermoid carcinoma}}
{{CMG}}{{AE}}{{MV}}
{{CMG}}{{AE}} , {{Badria}} , {{MV}}


==Overview==
==Overview==
If left untreated, patients with mucoepidermoid carcinoma may progress to develop sentinel metastasis to adjacent nodes. Common complications of mucoepidermoid carcinoma include facial [[deformity]]. [[Prognosis]] will generally depend on the clinical stage, tumor size, and histological grade. The overall recurrence rate will depend on the stage<ref name="pmid8842902">{{cite journal |vauthors=Plambeck K, Friedrich RE, Schmelzle R |title=Mucoepidermoid carcinoma of salivary gland origin: classification, clinical-pathological correlation, treatment results and long-term follow-up in 55 patients |journal=J Craniomaxillofac Surg |volume=24 |issue=3 |pages=133–9 |year=1996 |pmid=8842902 |doi= |url=}}</ref> Low grade tumors have a 90-98% survival and a low local [[recurrence]] rate.<ref name="pmid2306346">{{cite journal |vauthors=Armstrong JG, Harrison LB, Spiro RH, Fass DE, Strong EW, Fuks ZY |title=Malignant tumors of major salivary gland origin. A matched-pair analysis of the role of combined surgery and postoperative radiotherapy |journal=Arch. Otolaryngol. Head Neck Surg. |volume=116 |issue=3 |pages=290–3 |year=1990 |pmid=2306346 |doi= |url=}}</ref>
If left untreated, patients with mucoepidermoid carcinoma may progress to develop sentinel metastasis to adjacent [[Lymph node|lymph nodes]]. Common complications of mucoepidermoid carcinoma include [[facial]] [[deformity]], [[dysphagia]], and local [[lymph node]] metastasis. [[Prognosis]] will generally depend on the clinical stage, [[tumor]] size, and [[histological]] grade. The overall recurrence rate will depend on the stage. Low grade [[tumors]] have a 90-98% survival rate and a low rate of local [[recurrence]].
==Natural History==
*The majority of patients with mucoepidermoid carcinoma are initially [[asymptomatic]].
*Symptoms usually develop in the second or fifth decade of life, and initially patients complain of [[swallowing]] problems that are increased upon [[Mastication|mastication.]]
*If left untreated, patients with mucoepidermoid carcinoma may progress to develop sentinel [[lymph node]] [[metastasis]].
* Mode of metastasis may be<ref name="AsuquoNwagbara2013">{{cite journal|last1=Asuquo|first1=ME|last2=Nwagbara|first2=VI|last3=Umana|first3=AN|last4=Bassey|first4=G|last5=Ugbem|first5=T|title=Giant Mucoepidermoid Carcinoma of the Parotid Gland: A Case Report and Review of Literature|journal=Journal of Clinical & Experimental Oncology|volume=02|issue=01|year=2013|issn=23249110|doi=10.4172/2324-9110.1000103}}</ref>


==Natural History==
** [[Lymphatic]] ([[cervical]] [[lymph node]])
*Most patients with mucoepidermoid carcinoma are initially [[asymptomatic]].
** Hematogenous
*The symptoms of  usually develop in the second or fifth decade of life, and initially patients complain of swallowing problems that is increased upon chewing activity.
* Most common site for the metastasis is:
*If left untreated, patients with mucoepidermoid carcinoma  may progress to develop sentinel lymph node [[metastasis]].
**[[Lungs]]  
** [[Liver]]
** [[Brain]]
** [[Skin]]
** [[Ovary]]
** [[Peritoneum]]


==Complications==
==Complications==
*Common complications of mucoepidermoid carcinoma, include:<ref name="pmid8842902">{{cite journal |vauthors=Plambeck K, Friedrich RE, Schmelzle R |title=Mucoepidermoid carcinoma of salivary gland origin: classification, clinical-pathological correlation, treatment results and long-term follow-up in 55 patients |journal=J Craniomaxillofac Surg |volume=24 |issue=3 |pages=133–9 |year=1996 |pmid=8842902 |doi= |url=}}</ref>
*Common complications of mucoepidermoid carcinoma include:<ref name="pmid8842902">{{cite journal |vauthors=Plambeck K, Friedrich RE, Schmelzle R |title=Mucoepidermoid carcinoma of salivary gland origin: classification, clinical-pathological correlation, treatment results and long-term follow-up in 55 patients |journal=J Craniomaxillofac Surg |volume=24 |issue=3 |pages=133–9 |year=1996 |pmid=8842902 |doi= |url=}}</ref>
:*Facial deformity  
:*[[Facial]] deformity
:*[[Facial nerve palsy]]
:*[[Otorrhea]]
:*[[Lymph node metastases|Lymph node metastasis]]
:*[[Temporomandibular joint disorder|Temporomandibular malocclusion]]


* Cosmetic concerns leading to severe emotional stress
* [[Ulceration]]
* [[Bleeding]] from the [[tumor]]
* Compression of adjacent tissues which causes:
** [[Dysphagia]]
** [[Odynophagia]]
** Recurrence of the tumor after [[surgery]]
** [[Bones]] may undergo demineralization
** [[Submandibular tumor|Submandibular tumors]] commonly spread to the [[lymphatic system]]
** Intraoral mucoepidermoid carcinoma tumors tend to metastasize to the [[submandibular glands]], [[Post-auricular cyst|post-auricular]] and [[neck]] [[Lymph node|lymph nodes]]
** [[Palate]] [[tumors]] may metastasize to the [[skull]] base and [[respiratory tract]]
* Surgical complications: 
** [[Facial nerve palsy]]
** Gustatory sweating ([[Frey's syndrome]])
** Post-surgical wound [[infection]]
** Side effects from [[chemotherapy]] and [[radiation therapy]]
==Prognosis==
==Prognosis==
* Prognosis will generally depend on the clinical [[stage]], tumor size, and histological grade
* Prognosis will generally depend on the clinical [[stage]], tumor size, and histological grade.<ref name="pmid8842902">{{cite journal |vauthors=Plambeck K, Friedrich RE, Schmelzle R |title=Mucoepidermoid carcinoma of salivary gland origin: classification, clinical-pathological correlation, treatment results and long-term follow-up in 55 patients |journal=J Craniomaxillofac Surg |volume=24 |issue=3 |pages=133–9 |year=1996 |pmid=8842902 |doi= |url=}}</ref>
* The overall recurrence rate will depend on the stage<ref name="pmid8842902">{{cite journal |vauthors=Plambeck K, Friedrich RE, Schmelzle R |title=Mucoepidermoid carcinoma of salivary gland origin: classification, clinical-pathological correlation, treatment results and long-term follow-up in 55 patients |journal=J Craniomaxillofac Surg |volume=24 |issue=3 |pages=133–9 |year=1996 |pmid=8842902 |doi= |url=}}</ref>
* The overall recurrence rate depends on the stage of the tumor.<ref name="pmid8842902">{{cite journal |vauthors=Plambeck K, Friedrich RE, Schmelzle R |title=Mucoepidermoid carcinoma of salivary gland origin: classification, clinical-pathological correlation, treatment results and long-term follow-up in 55 patients |journal=J Craniomaxillofac Surg |volume=24 |issue=3 |pages=133–9 |year=1996 |pmid=8842902 |doi= |url=}}</ref><ref name="pmid2306346">{{cite journal |vauthors=Armstrong JG, Harrison LB, Spiro RH, Fass DE, Strong EW, Fuks ZY |title=Malignant tumors of major salivary gland origin. A matched-pair analysis of the role of combined surgery and postoperative radiotherapy |journal=Arch. Otolaryngol. Head Neck Surg. |volume=116 |issue=3 |pages=290–3 |year=1990 |pmid=2306346 |doi= |url=}}</ref>
* Low grade tumors have a 90-98% survival and a low local [[recurrence]] rate
 
* High grade tumors 30-54% surviving, and a high local recurrence rate<ref name="pmid2306346">{{cite journal |vauthors=Armstrong JG, Harrison LB, Spiro RH, Fass DE, Strong EW, Fuks ZY |title=Malignant tumors of major salivary gland origin. A matched-pair analysis of the role of combined surgery and postoperative radiotherapy |journal=Arch. Otolaryngol. Head Neck Surg. |volume=116 |issue=3 |pages=290–3 |year=1990 |pmid=2306346 |doi= |url=}}</ref>
* Low grade tumors have a 90-98% survival rate and a low rate of local [[recurrence]].
*The 5-year survival rate of patients with mucoepidermoid carcinoma:<ref name="tumor">Wealey, W. V., Perzin, K. H. and Smith, L. (1970), Mucoepidermoid carcinoma of salivary gland origin. Classification, clinical-pathologic correlation, and results of treatment. Cancer, 26: 368–388. doi: 10.1002/1097-0142(197008)26:2<368::AID-CNCR2820260219>3.0.CO;2-K</ref>
* High grade tumors have a 30-54% survival rate, and a high local recurrence rate.<ref name="pmid2306346">{{cite journal |vauthors=Armstrong JG, Harrison LB, Spiro RH, Fass DE, Strong EW, Fuks ZY |title=Malignant tumors of major salivary gland origin. A matched-pair analysis of the role of combined surgery and postoperative radiotherapy |journal=Arch. Otolaryngol. Head Neck Surg. |volume=116 |issue=3 |pages=290–3 |year=1990 |pmid=2306346 |doi= |url=}}</ref>
*The 5-year [[survival rate]] of patients with mucoepidermoid carcinoma is:<ref name="tumor">Wealey, W. V., Perzin, K. H. and Smith, L. (1970), Mucoepidermoid carcinoma of salivary gland origin. Classification, clinical-pathologic correlation, and results of treatment. Cancer, 26: 368–388. doi: 10.1002/1097-0142(197008)26:2<368::AID-CNCR2820260219>3.0.CO;2-K</ref>
:*Stage I 75%
:*Stage I 75%
:*Stage II 59%
:*Stage II 59%
:*Stage III 57%
:*Stage III 57%
:*Stage IV 28%
:*Stage IV 28%
* Overall incidence of [[lymph node]] involvement ranges from 18–28%.
* When distant metastases develop in patients with minor salivary gland tumours the average survival is 2.3 years
* Tumours of the major salivary glands is 2.6 years.<ref name="pmid707726">{{cite journal |vauthors=Spiro RH, Huvos AG, Berk R, Strong EW |title=Mucoepidermoid carcinoma of salivary gland origin. A clinicopathologic study of 367 cases |journal=Am. J. Surg. |volume=136 |issue=4 |pages=461–8 |date=October 1978 |pmid=707726 |doi= |url=}}</ref><ref name="pmid16857410">{{cite journal |vauthors=Rapidis AD, Givalos N, Gakiopoulou H, Stavrianos SD, Faratzis G, Lagogiannis GA, Katsilieris I, Patsouris E |title=Mucoepidermoid carcinoma of the salivary glands. Review of the literature and clinicopathological analysis of 18 patients |journal=Oral Oncol. |volume=43 |issue=2 |pages=130–6 |date=February 2007 |pmid=16857410 |doi=10.1016/j.oraloncology.2006.03.001 |url=}}</ref><ref name="ClodeFonseca1991">{{cite journal|last1=Clode|first1=Ana Luisa|last2=Fonseca|first2=Isabel|last3=Santos|first3=J. Rosa|last4=Soares|first4=Jorge|title=Mucoepidermoid carcinoma of the salivary glands: A reappraisal of the influence of tumor differentiation on prognosis|journal=Journal of Surgical Oncology|volume=46|issue=2|year=1991|pages=100–106|issn=00224790|doi=10.1002/jso.2930460207}}</ref>
<ref name="SpitzBatsakis1984">{{cite journal|last1=Spitz|first1=M. R.|last2=Batsakis|first2=J. G.|title=Major Salivary Gland Carcinoma: Descriptive Epidemiology and Survival of 498 Patients|journal=Archives of Otolaryngology - Head and Neck Surgery|volume=110|issue=1|year=1984|pages=45–49|issn=0886-4470|doi=10.1001/archotol.1984.00800270049013}}</ref><ref name="RapidisGivalos2007">{{cite journal|last1=Rapidis|first1=Alexander D.|last2=Givalos|first2=Nikolaos|last3=Gakiopoulou|first3=Hariklia|last4=Stavrianos|first4=Spyros D.|last5=Faratzis|first5=Gregory|last6=Lagogiannis|first6=George A.|last7=Katsilieris|first7=Ioannis|last8=Patsouris|first8=Efstratios|title=Mucoepidermoid carcinoma of the salivary glands.|journal=Oral Oncology|volume=43|issue=2|year=2007|pages=130–136|issn=13688375|doi=10.1016/j.oraloncology.2006.03.001}}</ref>


==References==
==References==
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[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Oral pathology]]
[[Category:Oral pathology]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Otolaryngology]]

Latest revision as of 16:02, 17 January 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: , Badria Munir M.B.B.S.[2] , Maria Fernanda Villarreal, M.D. [3]

Overview

If left untreated, patients with mucoepidermoid carcinoma may progress to develop sentinel metastasis to adjacent lymph nodes. Common complications of mucoepidermoid carcinoma include facial deformity, dysphagia, and local lymph node metastasis. Prognosis will generally depend on the clinical stage, tumor size, and histological grade. The overall recurrence rate will depend on the stage. Low grade tumors have a 90-98% survival rate and a low rate of local recurrence.

Natural History

  • The majority of patients with mucoepidermoid carcinoma are initially asymptomatic.
  • Symptoms usually develop in the second or fifth decade of life, and initially patients complain of swallowing problems that are increased upon mastication.
  • If left untreated, patients with mucoepidermoid carcinoma may progress to develop sentinel lymph node metastasis.
  • Mode of metastasis may be[1]

Complications

  • Common complications of mucoepidermoid carcinoma include:[2]

Prognosis

  • Prognosis will generally depend on the clinical stage, tumor size, and histological grade.[2]
  • The overall recurrence rate depends on the stage of the tumor.[2][3]
  • Low grade tumors have a 90-98% survival rate and a low rate of local recurrence.
  • High grade tumors have a 30-54% survival rate, and a high local recurrence rate.[3]
  • The 5-year survival rate of patients with mucoepidermoid carcinoma is:[4]
  • Stage I 75%
  • Stage II 59%
  • Stage III 57%
  • Stage IV 28%
  • Overall incidence of lymph node involvement ranges from 18–28%.
  • When distant metastases develop in patients with minor salivary gland tumours the average survival is 2.3 years
  • Tumours of the major salivary glands is 2.6 years.[5][6][7]

[8][9]

References

  1. ↑ Asuquo, ME; Nwagbara, VI; Umana, AN; Bassey, G; Ugbem, T (2013). "Giant Mucoepidermoid Carcinoma of the Parotid Gland: A Case Report and Review of Literature". Journal of Clinical & Experimental Oncology. 02 (01). doi:10.4172/2324-9110.1000103. ISSN 2324-9110.
  2. ↑ 2.0 2.1 2.2 Plambeck K, Friedrich RE, Schmelzle R (1996). "Mucoepidermoid carcinoma of salivary gland origin: classification, clinical-pathological correlation, treatment results and long-term follow-up in 55 patients". J Craniomaxillofac Surg. 24 (3): 133–9. PMID 8842902.
  3. ↑ 3.0 3.1 Armstrong JG, Harrison LB, Spiro RH, Fass DE, Strong EW, Fuks ZY (1990). "Malignant tumors of major salivary gland origin. A matched-pair analysis of the role of combined surgery and postoperative radiotherapy". Arch. Otolaryngol. Head Neck Surg. 116 (3): 290–3. PMID 2306346.
  4. ↑ Wealey, W. V., Perzin, K. H. and Smith, L. (1970), Mucoepidermoid carcinoma of salivary gland origin. Classification, clinical-pathologic correlation, and results of treatment. Cancer, 26: 368–388. doi: 10.1002/1097-0142(197008)26:2<368::AID-CNCR2820260219>3.0.CO;2-K
  5. ↑ Spiro RH, Huvos AG, Berk R, Strong EW (October 1978). "Mucoepidermoid carcinoma of salivary gland origin. A clinicopathologic study of 367 cases". Am. J. Surg. 136 (4): 461–8. PMID 707726.
  6. ↑ Rapidis AD, Givalos N, Gakiopoulou H, Stavrianos SD, Faratzis G, Lagogiannis GA, Katsilieris I, Patsouris E (February 2007). "Mucoepidermoid carcinoma of the salivary glands. Review of the literature and clinicopathological analysis of 18 patients". Oral Oncol. 43 (2): 130–6. doi:10.1016/j.oraloncology.2006.03.001. PMID 16857410.
  7. ↑ Clode, Ana Luisa; Fonseca, Isabel; Santos, J. Rosa; Soares, Jorge (1991). "Mucoepidermoid carcinoma of the salivary glands: A reappraisal of the influence of tumor differentiation on prognosis". Journal of Surgical Oncology. 46 (2): 100–106. doi:10.1002/jso.2930460207. ISSN 0022-4790.
  8. ↑ Spitz, M. R.; Batsakis, J. G. (1984). "Major Salivary Gland Carcinoma: Descriptive Epidemiology and Survival of 498 Patients". Archives of Otolaryngology - Head and Neck Surgery. 110 (1): 45–49. doi:10.1001/archotol.1984.00800270049013. ISSN 0886-4470.
  9. ↑ Rapidis, Alexander D.; Givalos, Nikolaos; Gakiopoulou, Hariklia; Stavrianos, Spyros D.; Faratzis, Gregory; Lagogiannis, George A.; Katsilieris, Ioannis; Patsouris, Efstratios (2007). "Mucoepidermoid carcinoma of the salivary glands". Oral Oncology. 43 (2): 130–136. doi:10.1016/j.oraloncology.2006.03.001. ISSN 1368-8375.

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