Mesterolone

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Mesterolone
Systematic (IUPAC) name
?
Identifiers
CAS number	1424-00-6
ATC code	G03BB01
PubChem	15020
Chemical data
Formula	C20H32O2
Mol. mass	304.467 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

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Mesterolone is an orally applicable androgen, and DHT derivative. It is sold under the brand name Proviron, by Schering. In the late 70's and early 80's it was used with some success in controlled studies of men suffering from various forms of depression.

In one randomized, double-blind 4-week trial, 38 dysthymic men were administered 75mg daily. Itil & Colleagues reported an improvement of symptoms which included anxiety, lack of drive and desire. Next, they administered a high dose (450mg/day) or placebo in a 6-week randomized trial of 52 men with a mean age of 40 years, suffering from dysthymia, unipolar and bipolar depression. Both the mesterolone and placebo groups improved significantly and there were no statistically significant differences between the two groups. In this series of studies mesterolone lead to a significant decrease in LH and testosterone levels. This is probably as a result of the extremely high dose used. In another, 100mg mesterolone cipionate was administered twice monthly. With regards to plasma T levels, there was no difference between the treated vs untreated group, and baseline LH levels were minimally affected.

Mesterolone is a relatively weak androgen and rarely used for replacement therapies.

References

• Frances Morrison, Mary. (2000) Hormones, Gender and the Aging Brain: The Endocrine Basis of Geriatric Psychiatry, Page 134, Cambridge University Press. ISBN 0521653045.

• Itil et al. The effects of mesterolone, a male sex hormone in depressed patients. 1984.

Cost Effectiveness of Mesterolone

| group5 = Clinical Trials Involving Mesterolone | list5 = Ongoing Trials on Mesterolone at Clinical Trials.gov • Trial results on Mesterolone • Clinical Trials on Mesterolone at Google

| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Mesterolone | list6 = US National Guidelines Clearinghouse on Mesterolone • NICE Guidance on Mesterolone • NHS PRODIGY Guidance • FDA on Mesterolone • CDC on Mesterolone

| group7 = Textbook Information on Mesterolone | list7 = Books and Textbook Information on Mesterolone

| group8 = Pharmacology Resources on Mesterolone | list8 = AND (Dose)}} Dosing of Mesterolone • AND (drug interactions)}} Drug interactions with Mesterolone • AND (side effects)}} Side effects of Mesterolone • AND (Allergy)}} Allergic reactions to Mesterolone • AND (overdose)}} Overdose information on Mesterolone • AND (carcinogenicity)}} Carcinogenicity information on Mesterolone • AND (pregnancy)}} Mesterolone in pregnancy • AND (pharmacokinetics)}} Pharmacokinetics of Mesterolone •

| group9 = Genetics, Pharmacogenomics, and Proteinomics of Mesterolone | list9 = AND (pharmacogenomics)}} Genetics of Mesterolone • AND (pharmacogenomics)}} Pharmacogenomics of Mesterolone • AND (proteomics)}} Proteomics of Mesterolone

| group10 = Newstories on Mesterolone | list10 = Mesterolone in the news • Be alerted to news on Mesterolone • News trends on Mesterolone</small>

| group11 = Commentary on Mesterolone | list11 = Blogs on Mesterolone

| group12 = Patient Resources on Mesterolone | list12 = Patient resources on Mesterolone • Discussion groups on Mesterolone • Patient Handouts on Mesterolone • Directions to Hospitals Treating Mesterolone • Risk calculators and risk factors for Mesterolone

| group13 = Healthcare Provider Resources on Mesterolone | list13 = Symptoms of Mesterolone • Causes & Risk Factors for Mesterolone • Diagnostic studies for Mesterolone • Treatment of Mesterolone

| group14 = Continuing Medical Education (CME) Programs on Mesterolone | list14 = CME Programs on Mesterolone

| group15 = International Resources on Mesterolone | list15 = Mesterolone en Espanol • Mesterolone en Francais

| group16 = Business Resources on Mesterolone | list16 = Mesterolone in the Marketplace • Patents on Mesterolone

| group17 = Informatics Resources on Mesterolone | list17 = List of terms related to Mesterolone

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