Major vault protein: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Major vault protein''' is a [[protein]] that in humans is encoded by the ''MVP'' [[gene]].<ref name="pmid7585126">{{cite journal | vauthors = Scheffer GL, Wijngaard PL, Flens MJ, Izquierdo MA, Slovak ML, Pinedo HM, Meijer CJ, Clevers HC, Scheper RJ | title = The drug resistance-related protein LRP is the human major vault protein | journal = Nature Medicine | volume = 1 | issue = 6 | pages = 578–82 | date = Jun 1995 | pmid = 7585126 | pmc = | doi = 10.1038/nm0695-578 }}</ref><ref name="entrez"/> 78 copies of the protein assemble into the large compartments called vaults, illustrated and discussed in the article on [[Vault (organelle)]].
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = no
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_MVP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1y7x.
| PDB = {{PDB2|1y7x}}
| Name = Major vault protein
| HGNCid = 7531
| Symbol = MVP
| AltSymbols =; LRP; VAULT1
| OMIM = 605088
| ECnumber = 
| Homologene = 3752
| MGIid = 1925638
| GeneAtlas_image1 = PBB_GE_MVP_202180_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MVP_gnf1h10986_at_tn.png
| GeneAtlas_image3 = PBB_GE_MVP_gnf1h10989_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0042493 |text = response to drug}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9961
    | Hs_Ensembl = ENSG00000013364
    | Hs_RefseqProtein = NP_005106
    | Hs_RefseqmRNA = NM_005115
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 29739281
    | Hs_GenLoc_end = 29766842
    | Hs_Uniprot = Q14764
    | Mm_EntrezGene = 78388
    | Mm_Ensembl = ENSMUSG00000030681
    | Mm_RefseqmRNA = NM_080638
    | Mm_RefseqProtein = NP_542369
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 126778012
    | Mm_GenLoc_end = 126805742
    | Mm_Uniprot = Q3THX5
  }}
}}
'''Major vault protein''', also known as '''MVP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MVP major vault protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9961| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes the major vault protein which is a lung infection resistance-related protein. [[Vault (organelle)|Vaults]] are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.<ref name="entrez">{{cite web | title = Entrez Gene: MVP major vault protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9961| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the major vault protein which is a lung resistance-related protein. [[Vault (organelle)|Vaults]] are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.<ref name="entrez">{{cite web | title = Entrez Gene: MVP major vault protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9961| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
Major vault protein has been shown to [[Protein-protein interaction|interact]] with [[Estrogen receptor alpha]],<ref name=pmid9628887>{{cite journal | vauthors = Abbondanza C, Rossi V, Roscigno A, Gallo L, Belsito A, Piluso G, Medici N, Nigro V, Molinari AM, Moncharmont B, Puca GA | title = Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell | journal = The Journal of Cell Biology | volume = 141 | issue = 6 | pages = 1301–10 | date = Jun 1998 | pmid = 9628887 | pmc = 2132791 | doi = 10.1083/jcb.141.6.1301 }}</ref> [[PTEN (gene)|PTEN]]<ref name=pmid12177006>{{cite journal | vauthors = Yu Z, Fotouhi-Ardakani N, Wu L, Maoui M, Wang S, Banville D, Shen SH | title = PTEN associates with the vault particles in HeLa cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 40247–52 | date = Oct 2002 | pmid = 12177006 | doi = 10.1074/jbc.M207608200 }}</ref> and [[PARP4]].<ref name=pmid11855821>{{cite journal | vauthors = van Zon A, Mossink MH, Schoester M, Scheffer GL, Scheper RJ, Sonneveld P, Wiemer EA | title = Structural domains of vault proteins: a role for the coiled coil domain in vault assembly | journal = Biochemical and Biophysical Research Communications | volume = 291 | issue = 3 | pages = 535–41 | date = Mar 2002 | pmid = 11855821 | doi = 10.1006/bbrc.2002.6472 }}</ref><ref name=pmid10477748>{{cite journal | vauthors = Kickhoefer VA, Siva AC, Kedersha NL, Inman EM, Ruland C, Streuli M, Rome LH | title = The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase | journal = The Journal of Cell Biology | volume = 146 | issue = 5 | pages = 917–28 | date = Sep 1999 | pmid = 10477748 | pmc = 2169495 | doi = 10.1083/jcb.146.5.917 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Izquierdo MA, Scheffer GL, Flens MJ, Schroeijers AB, van der Valk P, Scheper RJ | title = Major vault protein LRP-related multidrug resistance | journal = European Journal of Cancer | volume = 32A | issue = 6 | pages = 979–84 | date = Jun 1996 | pmid = 8763338 | doi = 10.1016/0959-8049(96)00053-6 }}
| citations =
* {{cite journal | vauthors = Slovak ML, Ho JP, Cole SP, Deeley RG, Greenberger L, de Vries EG, Broxterman HJ, Scheffer GL, Scheper RJ | title = The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification | journal = Cancer Research | volume = 55 | issue = 19 | pages = 4214–9 | date = Oct 1995 | pmid = 7671223 | doi =  }}
*{{cite journal | author=Izquierdo MA, Scheffer GL, Flens MJ, ''et al.'' |title=Major vault protein LRP-related multidrug resistance. |journal=Eur. J. Cancer |volume=32A |issue= 6 |pages= 979-84 |year= 1996 |pmid= 8763338 |doi= }}
* {{cite journal | vauthors = Izquierdo MA, Scheffer GL, Flens MJ, Giaccone G, Broxterman HJ, Meijer CJ, van der Valk P, Scheper RJ | title = Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors | journal = The American Journal of Pathology | volume = 148 | issue = 3 | pages = 877–87 | date = Mar 1996 | pmid = 8774142 | pmc = 1861735 | doi =  }}
*{{cite journal | author=Scheffer GL, Wijngaard PL, Flens MJ, ''et al.'' |title=The drug resistance-related protein LRP is the human major vault protein. |journal=Nat. Med. |volume=1 |issue= 6 |pages= 578-82 |year= 1995 |pmid= 7585126 |doi=  }}
* {{cite journal | vauthors = Dingemans AM, van Ark-Otte J, van der Valk P, Apolinario RM, Scheper RJ, Postmus PE, Giaccone G | title = Expression of the human major vault protein LRP in human lung cancer samples and normal lung tissues | journal = Annals of Oncology | volume = 7 | issue = 6 | pages = 625–30 | date = Aug 1996 | pmid = 8879378 | doi = 10.1093/oxfordjournals.annonc.a010681 }}
*{{cite journal | author=Slovak ML, Ho JP, Cole SP, ''et al.'' |title=The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification. |journal=Cancer Res. |volume=55 |issue= 19 |pages= 4214-9 |year= 1995 |pmid= 7671223 |doi=  }}
* {{cite journal | vauthors = Sugawara I, Akiyama S, Scheper RJ, Itoyama S | title = Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP | journal = Cancer Letters | volume = 112 | issue = 1 | pages = 23–31 | date = Jan 1997 | pmid = 9029166 | doi = 10.1016/S0304-3835(96)04542-9 }}
*{{cite journal | author=Izquierdo MA, Scheffer GL, Flens MJ, ''et al.'' |title=Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors. |journal=Am. J. Pathol. |volume=148 |issue= 3 |pages= 877-87 |year= 1997 |pmid= 8774142 |doi= }}
* {{cite journal | vauthors = Abbondanza C, Rossi V, Roscigno A, Gallo L, Belsito A, Piluso G, Medici N, Nigro V, Molinari AM, Moncharmont B, Puca GA | title = Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell | journal = The Journal of Cell Biology | volume = 141 | issue = 6 | pages = 1301–10 | date = Jun 1998 | pmid = 9628887 | pmc = 2132791 | doi = 10.1083/jcb.141.6.1301 }}
*{{cite journal | author=Dingemans AM, van Ark-Otte J, van der Valk P, ''et al.'' |title=Expression of the human major vault protein LRP in human lung cancer samples and normal lung tissues. |journal=Ann. Oncol. |volume=7 |issue= 6 |pages= 625-30 |year= 1997 |pmid= 8879378 |doi= }}
* {{cite journal | vauthors = Ikeda K, Oka M, Yamada Y, Soda H, Fukuda M, Kinoshita A, Tsukamoto K, Noguchi Y, Isomoto H, Takeshima F, Murase K, Kamihira S, Tomonaga M, Kohno S | title = Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes | journal = International Journal of Cancer | volume = 82 | issue = 4 | pages = 599–604 | date = Aug 1999 | pmid = 10404077 | doi = 10.1002/(SICI)1097-0215(19990812)82:4<599::AID-IJC21>3.0.CO;2-R }}
*{{cite journal | author=Sugawara I, Akiyama S, Scheper RJ, Itoyama S |title=Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP. |journal=Cancer Lett. |volume=112 |issue= 1 |pages= 23-31 |year= 1997 |pmid= 9029166 |doi= 10.1016/S0304-3835(96)04542-9 }}
* {{cite journal | vauthors = Rimsza LM, Campbell K, Dalton WS, Salmon S, Willcox G, Grogan TM | title = The major vault protein (MVP), a new multidrug resistance associated protein, is frequently expressed in multiple myeloma | journal = Leukemia & Lymphoma | volume = 34 | issue = 3-4 | pages = 315–24 | date = Jul 1999 | pmid = 10439368 | doi = 10.3109/10428199909050956 }}
*{{cite journal | author=Abbondanza C, Rossi V, Roscigno A, ''et al.'' |title=Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell. |journal=J. Cell Biol. |volume=141 |issue= 6 |pages= 1301-10 |year= 1998 |pmid= 9628887 |doi= }}
* {{cite journal | vauthors = Kickhoefer VA, Siva AC, Kedersha NL, Inman EM, Ruland C, Streuli M, Rome LH | title = The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase | journal = The Journal of Cell Biology | volume = 146 | issue = 5 | pages = 917–28 | date = Sep 1999 | pmid = 10477748 | pmc = 2169495 | doi = 10.1083/jcb.146.5.917 }}
*{{cite journal | author=Ikeda K, Oka M, Yamada Y, ''et al.'' |title=Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes. |journal=Int. J. Cancer |volume=82 |issue= 4 |pages= 599-604 |year= 1999 |pmid= 10404077 |doi= }}
* {{cite journal | vauthors = Kickhoefer VA, Stephen AG, Harrington L, Robinson MO, Rome LH | title = Vaults and telomerase share a common subunit, TEP1 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 46 | pages = 32712–7 | date = Nov 1999 | pmid = 10551828 | doi = 10.1074/jbc.274.46.32712 }}
*{{cite journal | author=Rimsza LM, Campbell K, Dalton WS, ''et al.'' |title=The major vault protein (MVP), a new multidrug resistance associated protein, is frequently expressed in multiple myeloma. |journal=Leuk. Lymphoma |volume=34 |issue= 3-4 |pages= 315-24 |year= 1999 |pmid= 10439368 |doi= }}
* {{cite journal | vauthors = Lange C, Walther W, Schwabe H, Stein U | title = Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter | journal = Biochemical and Biophysical Research Communications | volume = 278 | issue = 1 | pages = 125–33 | date = Nov 2000 | pmid = 11071864 | doi = 10.1006/bbrc.2000.3782 }}
*{{cite journal | author=Kickhoefer VA, Siva AC, Kedersha NL, ''et al.'' |title=The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase. |journal=J. Cell Biol. |volume=146 |issue= 5 |pages= 917-28 |year= 1999 |pmid= 10477748 |doi= }}
* {{cite journal | vauthors = Holzmann K, Ambrosch I, Elbling L, Micksche M, Berger W | title = A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant | journal = FEBS Letters | volume = 494 | issue = 1-2 | pages = 99–104 | date = Apr 2001 | pmid = 11297743 | doi = 10.1016/S0014-5793(01)02318-3 }}
*{{cite journal | author=Kickhoefer VA, Stephen AG, Harrington L, ''et al.'' |title=Vaults and telomerase share a common subunit, TEP1. |journal=J. Biol. Chem. |volume=274 |issue= 46 |pages= 32712-7 |year= 2000 |pmid= 10551828 |doi= }}
* {{cite journal | vauthors = van Zon A, Mossink MH, Schoester M, Scheffer GL, Scheper RJ, Sonneveld P, Wiemer EA | title = Structural domains of vault proteins: a role for the coiled coil domain in vault assembly | journal = Biochemical and Biophysical Research Communications | volume = 291 | issue = 3 | pages = 535–41 | date = Mar 2002 | pmid = 11855821 | doi = 10.1006/bbrc.2002.6472 }}
*{{cite journal | author=Lange C, Walther W, Schwabe H, Stein U |title=Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter. |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 1 |pages= 125-33 |year= 2001 |pmid= 11071864 |doi= 10.1006/bbrc.2000.3782 }}
* {{cite journal | vauthors = Sakaki Y, Terashi K, Yamaguchi A, Kawamata N, Tokito Y, Mori H, Umehara M, Yoshiyama T, Ohtsubo H, Arimura K, Arima N, Tei C | title = Human T-cell lymphotropic virus type I Tax activates lung resistance-related protein expression in leukemic clones established from an adult T-cell leukemia patient | journal = Experimental Hematology | volume = 30 | issue = 4 | pages = 340–5 | date = Apr 2002 | pmid = 11937269 | doi = 10.1016/S0301-472X(02)00775-0 }}
*{{cite journal | author=Holzmann K, Ambrosch I, Elbling L, ''et al.'' |title=A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant. |journal=FEBS Lett. |volume=494 |issue= 1-2 |pages= 99-104 |year= 2001 |pmid= 11297743 |doi= }}
* {{cite journal | vauthors = Zhao Y, Yu L, Wang Q, Lou F, Pu J | title = [The relationship between expression of lung resistance-related protein gene or multidrug resistance-associated protein gene and prognosis in newly diagnosed acute leukemia] | journal = Zhonghua Nei Ke Za Zhi | volume = 41 | issue = 3 | pages = 183–5 | date = Mar 2002 | pmid = 11940320 | doi =  }}
*{{cite journal | author=van Zon A, Mossink MH, Schoester M, ''et al.'' |title=Structural domains of vault proteins: a role for the coiled coil domain in vault assembly. |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue= 3 |pages= 535-41 |year= 2002 |pmid= 11855821 |doi= 10.1006/bbrc.2002.6472 }}
* {{cite journal | vauthors = Scheffer GL, Pijnenborg AC, Smit EF, Müller M, Postma DS, Timens W, van der Valk P, de Vries EG, Scheper RJ | title = Multidrug resistance related molecules in human and murine lung | journal = Journal of Clinical Pathology | volume = 55 | issue = 5 | pages = 332–9 | date = May 2002 | pmid = 11986335 | pmc = 1769658 | doi = 10.1136/jcp.55.5.332 }}
*{{cite journal | author=Sakaki Y, Terashi K, Yamaguchi A, ''et al.'' |title=Human T-cell lymphotropic virus type I Tax activates lung resistance-related protein expression in leukemic clones established from an adult T-cell leukemia patient. |journal=Exp. Hematol. |volume=30 |issue= 4 |pages= 340-5 |year= 2002 |pmid= 11937269 |doi=  }}
* {{cite journal | vauthors = van den Heuvel-Eibrink MM, Wiemer EA, Prins A, Meijerink JP, Vossebeld PJ, van der Holt B, Pieters R, Sonneveld P | title = Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML) | journal = Leukemia | volume = 16 | issue = 5 | pages = 833–9 | date = May 2002 | pmid = 11986944 | doi = 10.1038/sj.leu.2402496 }}
*{{cite journal | author=Zhao Y, Yu L, Wang Q, ''et al.'' |title=[The relationship between expression of lung resistance-related protein gene or multidrug resistance-associated protein gene and prognosis in newly diagnosed acute leukemia] |journal=Zhonghua Nei Ke Za Zhi |volume=41 |issue= 3 |pages= 183-5 |year= 2002 |pmid= 11940320 |doi= }}
* {{cite journal | vauthors = Yu Z, Fotouhi-Ardakani N, Wu L, Maoui M, Wang S, Banville D, Shen SH | title = PTEN associates with the vault particles in HeLa cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 40247–52 | date = Oct 2002 | pmid = 12177006 | doi = 10.1074/jbc.M207608200 }}
*{{cite journal | author=Scheffer GL, Pijnenborg AC, Smit EF, ''et al.'' |title=Multidrug resistance related molecules in human and murine lung. |journal=J. Clin. Pathol. |volume=55 |issue= 5 |pages= 332-9 |year= 2002 |pmid= 11986335 |doi= }}
*{{cite journal | author=van den Heuvel-Eibrink MM, Wiemer EA, Prins A, ''et al.'' |title=Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML). |journal=Leukemia |volume=16 |issue= 5 |pages= 833-9 |year= 2002 |pmid= 11986944 |doi= 10.1038/sj.leu.2402496 }}
*{{cite journal  | author=Yu Z, Fotouhi-Ardakani N, Wu L, ''et al.'' |title=PTEN associates with the vault particles in HeLa cells. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40247-52 |year= 2002 |pmid= 12177006 |doi= 10.1074/jbc.M207608200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=9961}}
{{WikiDoc Sources}}
{{Ribonucleoproteins}}
 
[[Category:Human proteins]]
 
 
{{gene-16-stub}}

Latest revision as of 22:01, 25 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Major vault protein is a protein that in humans is encoded by the MVP gene.[1][2] 78 copies of the protein assemble into the large compartments called vaults, illustrated and discussed in the article on Vault (organelle).

Function

This gene encodes the major vault protein which is a lung infection resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.[2]

Interactions

Major vault protein has been shown to interact with Estrogen receptor alpha,[3] PTEN[4] and PARP4.[5][6]

References

  1. ↑ Scheffer GL, Wijngaard PL, Flens MJ, Izquierdo MA, Slovak ML, Pinedo HM, Meijer CJ, Clevers HC, Scheper RJ (Jun 1995). "The drug resistance-related protein LRP is the human major vault protein". Nature Medicine. 1 (6): 578–82. doi:10.1038/nm0695-578. PMID 7585126.
  2. ↑ 2.0 2.1 "Entrez Gene: MVP major vault protein".
  3. ↑ Abbondanza C, Rossi V, Roscigno A, Gallo L, Belsito A, Piluso G, Medici N, Nigro V, Molinari AM, Moncharmont B, Puca GA (Jun 1998). "Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell Biology. 141 (6): 1301–10. doi:10.1083/jcb.141.6.1301. PMC 2132791. PMID 9628887.
  4. ↑ Yu Z, Fotouhi-Ardakani N, Wu L, Maoui M, Wang S, Banville D, Shen SH (Oct 2002). "PTEN associates with the vault particles in HeLa cells". The Journal of Biological Chemistry. 277 (43): 40247–52. doi:10.1074/jbc.M207608200. PMID 12177006.
  5. ↑ van Zon A, Mossink MH, Schoester M, Scheffer GL, Scheper RJ, Sonneveld P, Wiemer EA (Mar 2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochemical and Biophysical Research Communications. 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. PMID 11855821.
  6. ↑ Kickhoefer VA, Siva AC, Kedersha NL, Inman EM, Ruland C, Streuli M, Rome LH (Sep 1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". The Journal of Cell Biology. 146 (5): 917–28. doi:10.1083/jcb.146.5.917. PMC 2169495. PMID 10477748.

Further reading

  • Izquierdo MA, Scheffer GL, Flens MJ, Schroeijers AB, van der Valk P, Scheper RJ (Jun 1996). "Major vault protein LRP-related multidrug resistance". European Journal of Cancer. 32A (6): 979–84. doi:10.1016/0959-8049(96)00053-6. PMID 8763338.
  • Slovak ML, Ho JP, Cole SP, Deeley RG, Greenberger L, de Vries EG, Broxterman HJ, Scheffer GL, Scheper RJ (Oct 1995). "The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification". Cancer Research. 55 (19): 4214–9. PMID 7671223.
  • Izquierdo MA, Scheffer GL, Flens MJ, Giaccone G, Broxterman HJ, Meijer CJ, van der Valk P, Scheper RJ (Mar 1996). "Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors". The American Journal of Pathology. 148 (3): 877–87. PMC 1861735. PMID 8774142.
  • Dingemans AM, van Ark-Otte J, van der Valk P, Apolinario RM, Scheper RJ, Postmus PE, Giaccone G (Aug 1996). "Expression of the human major vault protein LRP in human lung cancer samples and normal lung tissues". Annals of Oncology. 7 (6): 625–30. doi:10.1093/oxfordjournals.annonc.a010681. PMID 8879378.
  • Sugawara I, Akiyama S, Scheper RJ, Itoyama S (Jan 1997). "Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP". Cancer Letters. 112 (1): 23–31. doi:10.1016/S0304-3835(96)04542-9. PMID 9029166.
  • Abbondanza C, Rossi V, Roscigno A, Gallo L, Belsito A, Piluso G, Medici N, Nigro V, Molinari AM, Moncharmont B, Puca GA (Jun 1998). "Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell Biology. 141 (6): 1301–10. doi:10.1083/jcb.141.6.1301. PMC 2132791. PMID 9628887.
  • Ikeda K, Oka M, Yamada Y, Soda H, Fukuda M, Kinoshita A, Tsukamoto K, Noguchi Y, Isomoto H, Takeshima F, Murase K, Kamihira S, Tomonaga M, Kohno S (Aug 1999). "Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes". International Journal of Cancer. 82 (4): 599–604. doi:10.1002/(SICI)1097-0215(19990812)82:4<599::AID-IJC21>3.0.CO;2-R. PMID 10404077.
  • Rimsza LM, Campbell K, Dalton WS, Salmon S, Willcox G, Grogan TM (Jul 1999). "The major vault protein (MVP), a new multidrug resistance associated protein, is frequently expressed in multiple myeloma". Leukemia & Lymphoma. 34 (3–4): 315–24. doi:10.3109/10428199909050956. PMID 10439368.
  • Kickhoefer VA, Siva AC, Kedersha NL, Inman EM, Ruland C, Streuli M, Rome LH (Sep 1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". The Journal of Cell Biology. 146 (5): 917–28. doi:10.1083/jcb.146.5.917. PMC 2169495. PMID 10477748.
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