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The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.[2]
↑De Falco G, Bagella L, Claudio PP, De Luca A, Fu Y, Calabretta B, Sala A, Giordano A (Jan 2000). "Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation". Oncogene. 19 (3): 373–9. doi:10.1038/sj.onc.1203305. PMID10656684.
↑Bessa M, Saville MK, Watson RJ (Jun 2001). "Inhibition of cyclin A/Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions with DNA or the CBP coactivator". Oncogene. 20 (26): 3376–86. doi:10.1038/sj.onc.1204439. PMID11423988.
↑Müller-Tidow C, Wang W, Idos GE, Diederichs S, Yang R, Readhead C, Berdel WE, Serve H, Saville M, Watson R, Koeffler HP (April 2001). "Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function". Blood. 97: 2091–7. doi:10.1182/blood.V97.7.2091. PMID11264176.
↑ 6.06.1Joaquin M, Watson RJ (Nov 2003). "The cell cycle-regulated B-Myb transcription factor overcomes cyclin-dependent kinase inhibitory activity of p57(KIP2) by interacting with its cyclin-binding domain". The Journal of Biological Chemistry. 278 (45): 44255–64. doi:10.1074/jbc.M308953200. PMID12947099.
↑Johnson LR, Johnson TK, Desler M, Luster TA, Nowling T, Lewis RE, Rizzino A (Feb 2002). "Effects of B-Myb on gene transcription: phosphorylation-dependent activity and acetylation by p300". The Journal of Biological Chemistry. 277 (6): 4088–97. doi:10.1074/jbc.M105112200. PMID11733503.
↑Cervellera MN, Sala A (Apr 2000). "Poly(ADP-ribose) polymerase is a B-MYB coactivator". The Journal of Biological Chemistry. 275 (14): 10692–6. doi:10.1074/jbc.275.14.10692. PMID10744766.
↑Joaquin M, Bessa M, Saville MK, Watson RJ (Nov 2002). "B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107". Oncogene. 21 (52): 7923–32. doi:10.1038/sj.onc.1206001. PMID12439743.
Further reading
Golay J, Cusmano G, Introna M (Jul 1992). "Independent regulation of c-myc, B-myb, and c-myb gene expression by inducers and inhibitors of proliferation in human B lymphocytes". Journal of Immunology. 149 (1): 300–8. PMID1376749.
Reiss K, Travali S, Calabretta B, Baserga R (Sep 1991). "Growth regulated expression of B-myb in fibroblasts and hematopoietic cells". Journal of Cellular Physiology. 148 (3): 338–43. doi:10.1002/jcp.1041480303. PMID1717494.
Golay J, Capucci A, Arsura M, Castellano M, Rizzo V, Introna M (Jan 1991). "Expression of c-myb and B-myb, but not A-myb, correlates with proliferation in human hematopoietic cells". Blood. 77 (1): 149–58. PMID1984793.
Takemoto Y, Tashiro S, Handa H, Ishii S (Aug 1994). "Multiple nuclear localization signals of the B-myb gene product". FEBS Letters. 350 (1): 55–60. doi:10.1016/0014-5793(94)00733-0. PMID8062924.
Zhou W, Takuwa N, Kumada M, Takuwa Y (Feb 1994). "E2F1, B-myb and selective members of cyclin/cdk subunits are targets for protein kinase C-mediated bimodal growth regulation in vascular endothelial cells". Biochemical and Biophysical Research Communications. 199 (1): 191–8. doi:10.1006/bbrc.1994.1213. PMID8123011.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Arsura M, Luchetti MM, Erba E, Golay J, Rambaldi A, Introna M (Apr 1994). "Dissociation between p93B-myb and p75c-myb expression during the proliferation and differentiation of human myeloid cell lines". Blood. 83 (7): 1778–90. PMID8142646.
Nakagoshi H, Takemoto Y, Ishii S (Jul 1993). "Functional domains of the human B-myb gene product". The Journal of Biological Chemistry. 268 (19): 14161–7. PMID8314782.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Saville MK, Watson RJ (Nov 1998). "The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties". Oncogene. 17 (21): 2679–89. doi:10.1038/sj.onc.1202503. PMID9840932.
Bartsch O, Horstmann S, Toprak K, Klempnauer KH, Ferrari S (Mar 1999). "Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb". European Journal of Biochemistry / FEBS. 260 (2): 384–91. doi:10.1046/j.1432-1327.1999.00191.x. PMID10095772.
Kim T, Jung H, Min S, Kim KT, Ha H (Oct 1999). "B-myb proto-oncogene products interact in vivo with each other via the carboxy-terminal conserved region". FEBS Letters. 460 (2): 363–8. doi:10.1016/S0014-5793(99)01375-7. PMID10544265.
Johnson TK, Schweppe RE, Septer J, Lewis RE (Dec 1999). "Phosphorylation of B-Myb regulates its transactivation potential and DNA binding". The Journal of Biological Chemistry. 274 (51): 36741–9. doi:10.1074/jbc.274.51.36741. PMID10593981.
Horstmann S, Ferrari S, Klempnauer KH (Jan 2000). "Regulation of B-Myb activity by cyclin D1". Oncogene. 19 (2): 298–306. doi:10.1038/sj.onc.1203302. PMID10645009.
De Falco G, Bagella L, Claudio PP, De Luca A, Fu Y, Calabretta B, Sala A, Giordano A (Jan 2000). "Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation". Oncogene. 19 (3): 373–9. doi:10.1038/sj.onc.1203305. PMID10656684.
Cervellera MN, Sala A (Apr 2000). "Poly(ADP-ribose) polymerase is a B-MYB coactivator". The Journal of Biological Chemistry. 275 (14): 10692–6. doi:10.1074/jbc.275.14.10692. PMID10744766.