MED14

Cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa
Identifiers
Symbols	CRSP2 ; CSRP; CRSP150; CXorf4; DRIP150; EXLM1; MED14; MGC104513; RGR1; TRAP170
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22082
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE CRSP2 202611 s at tn.png
File:PBB GE CRSP2 202610 s at tn.png
File:PBB GE CRSP2 202612 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa, also known as CRSP2, is a human gene.

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.

Further reading

• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fondell JD, Ge H, Roeder RG (1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8329–33. PMID 8710870.CS1 maint: Multiple names: authors list (link)
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoshikawa H, Fujiyama A, Nakai K; et al. (1998). "Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional DNA mapping method". Genomics. 49 (2): 237–46. doi:10.1006/geno.1998.5246. PMID 9598311.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sun X, Zhang Y, Cho H; et al. (1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell. 2 (2): 213–22. PMID 9734358.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ryu S, Zhou S, Ladurner AG, Tjian R (1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. doi:10.1038/17141. PMID 9989412.CS1 maint: Multiple names: authors list (link)
• Gu W, Malik S, Ito M; et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Mol. Cell. 3 (1): 97–108. PMID 10024883.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ito M, Yuan CX, Malik S; et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. PMID 10198638.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rachez C, Lemon BD, Suldan Z; et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. doi:10.1038/19783. PMID 10235266.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Näär AM, Beaurang PA, Zhou S; et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hittelman AB, Burakov D, Iñiguez-Lluhí JA; et al. (1999). "Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins". EMBO J. 18 (19): 5380–8. doi:10.1093/emboj/18.19.5380. PMID 10508170.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ge K, Guermah M, Yuan CX; et al. (2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis". Nature. 417 (6888): 563–7. doi:10.1038/417563a. PMID 12037571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Malik S, Wallberg AE, Kang YK, Roeder RG (2002). "TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4". Mol. Cell. Biol. 22 (15): 5626–37. PMID 12101254.CS1 maint: Multiple names: authors list (link)
• Wang Q, Sharma D, Ren Y, Fondell JD (2003). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression". J. Biol. Chem. 277 (45): 42852–8. doi:10.1074/jbc.M206061200. PMID 12218053.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lau JF, Nusinzon I, Burakov D; et al. (2003). "Role of metazoan mediator proteins in interferon-responsive transcription". Mol. Cell. Biol. 23 (2): 620–8. PMID 12509459.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Demirci FY, Ramser J, White NJ; et al. (2004). "Refinement of the physical location and the genomic characterization of the CRSP2 (EXLM1) gene on Xp11.4". DNA Seq. 14 (2): 123–7. PMID 12825353.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sato S, Tomomori-Sato C, Banks CA; et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wallberg AE, Yamamura S, Malik S; et al. (2004). "Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha". Mol. Cell. 12 (5): 1137–49. PMID 14636573.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tomomori-Sato C, Sato S, Parmely TJ; et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)