MAGI2

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Membrane associated guanylate kinase, WW and PDZ domain containing 2
File:PBB Protein MAGI2 image.jpg
PDB rendering based on 1uep.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols MAGI2 ; AIP1; ACVRIP1; ARIP1; MAGI-2
External IDs Template:OMIM5 Template:MGI HomoloGene: 8189
RNA expression pattern
File:PBB GE MAGI2 209737 at tn.png
File:PBB GE MAGI2 207702 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Membrane associated guanylate kinase, WW and PDZ domain containing 2, also known as MAGI2, is a human gene.[1]

The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2".

Further reading

  • Wood JD, Yuan J, Margolis RL; et al. (1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol. Cell. Neurosci. 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693.
  • Ishikawa K, Nagase T, Suyama M; et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. PMID 9734811.
  • "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.
  • Ide N, Hata Y, Deguchi M; et al. (1999). "Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin". Biochem. Biophys. Res. Commun. 256 (3): 456–61. doi:10.1006/bbrc.1999.0364. PMID 10080919.
  • Shoji H, Tsuchida K, Kishi H; et al. (2000). "Identification and characterization of a PDZ protein that interacts with activin type II receptors". J. Biol. Chem. 275 (8): 5485–92. PMID 10681527.
  • Wu X, Hepner K, Castelino-Prabhu S; et al. (2000). "Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4233–8. PMID 10760291.
  • Xu J, Paquet M, Lau AG; et al. (2001). "beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95". J. Biol. Chem. 276 (44): 41310–7. doi:10.1074/jbc.M107480200. PMID 11526121.
  • Vazquez F, Grossman SR, Takahashi Y; et al. (2002). "Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex". J. Biol. Chem. 276 (52): 48627–30. doi:10.1074/jbc.C100556200. PMID 11707428.
  • Nishimura W, Yao I, Iida J; et al. (2002). "Interaction of synaptic scaffolding molecule and Beta -catenin". J. Neurosci. 22 (3): 757–65. PMID 11826105.
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Yap CC, Muto Y, Kishida H; et al. (2003). "PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein". Biochem. Biophys. Res. Commun. 301 (4): 1122–8. PMID 12589829.
  • Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
  • Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
  • Evgrafov OV, Mersiyanova I, Irobi J; et al. (2004). "Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy". Nat. Genet. 36 (6): 602–6. doi:10.1038/ng1354. PMID 15122254.
  • Franklin JL, Yoshiura K, Dempsey PJ; et al. (2005). "Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein". Exp. Cell Res. 303 (2): 457–70. doi:10.1016/j.yexcr.2004.10.007. PMID 15652357.
  • Hu Y, Li Z, Guo L; et al. (2007). "MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells". Arch. Biochem. Biophys. 467 (1): 1–9. doi:10.1016/j.abb.2007.07.027. PMID 17880912.

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