Lupus nephritis classification

Jump to navigation Jump to search

Lupus nephritis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Lupus nephritis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Lupus nephritis classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Lupus nephritis classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Lupus nephritis classification

CDC on Lupus nephritis classification

Lupus nephritis classification in the news

Blogs on Lupus nephritis classification

Directions to Hospitals Treating Lupus nephritis

Risk calculators and risk factors for Lupus nephritis classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:  Omer Kamal, M.D.[2]

Overview

Lupus nephritis may be classified according to The Renal Pathology Society/International Society of Nephrology (RPS/ISN) classification which includes minimal mesangial lupus nephritis (class I), mesangial proliferative lupus nephritis (class II), focal lupus nephritis (class III), diffuse lupus nephritis (class IV), lupus membranous nephropathy (class V) and advanced sclerosing lupus nephritis (class VI)

Classification

The Renal Pathology Society/International Society of Nephrology (RPS/ISN) classification:[1][2][3][4][5][6]

Minimal mesangial lupus nephritis (class I)

Mesangial proliferative lupus nephritis (class II)

Focal lupus nephritis (class III)

Subclasses on the basis of inflammatory activity of the lesions:

  • Class III (A) called focal proliferative lupus nephritis: Just active lesions.[8][9]
  • Class III (A/C) called focal proliferative and sclerosing lupus nephritis: Active and chronic lesions[9]
  • Class III (C) called focal sclerosing lupus nephritis: Chronic inactive lesions with scarring.

Diffuse lupus nephritis (class IV)

Subclasses on the basis of involvment of affected glomeruli: Segmental (S) or global (G) and by the inflammation

  • Class IV-S (A), class IV-S with active lesions called diffuse segmental proliferative nephritis.
  • Class IV-G (A), class IV-G associated with active lesions called diffuse global proliferative nephritis.
  • Class IV-S (A/C),associated with active and chronic lesions called diffuse segmental proliferative and sclerosing nephritis.
  • Class IV-G (A/C), class IV-G with active and chronic lesions called diffuse global proliferative and sclerosing nephritis.
  • Class IV-S (C), associated with chronic inactive lesions with scars called diffuse segmental sclerosing lupus nephritis.
  • Class IV-G (C), class IV-G with chronic inactive lesions with scars called diffuse global sclerosing lupus nephritis

Lupus membranous nephropathy (class V)

Advanced sclerosing lupus nephritis (class VI)

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, Balow JE, Bruijn JA, Cook T, Ferrario F, Fogo AB, Ginzler EM, Hebert L, Hill G, Hill P, Jennette JC, Kong NC, Lesavre P, Lockshin M, Looi LM, Makino H, Moura LA, Nagata M (February 2004). "The classification of glomerulonephritis in systemic lupus erythematosus revisited". Kidney Int. 65 (2): 521–30. doi:10.1111/j.1523-1755.2004.00443.x. PMID 14717922.
  2. Furness PN, Taub N (August 2006). "Interobserver reproducibility and application of the ISN/RPS classification of lupus nephritis-a UK-wide study". Am. J. Surg. Pathol. 30 (8): 1030–5. PMID 16861976.
  3. Yokoyama H, Wada T, Hara A, Yamahana J, Nakaya I, Kobayashi M, Kitagawa K, Kokubo S, Iwata Y, Yoshimoto K, Shimizu K, Sakai N, Furuichi K (December 2004). "The outcome and a new ISN/RPS 2003 classification of lupus nephritis in Japanese". Kidney Int. 66 (6): 2382–8. doi:10.1111/j.1523-1755.2004.66027.x. PMID 15569330.
  4. Markowitz GS, D'Agati VD (March 2007). "The ISN/RPS 2003 classification of lupus nephritis: an assessment at 3 years". Kidney Int. 71 (6): 491–5. doi:10.1038/sj.ki.5002118. PMID 17264872.
  5. Markowitz GS, D'Agati VD (May 2009). "Classification of lupus nephritis". Curr. Opin. Nephrol. Hypertens. 18 (3): 220–5. PMID 19374008.
  6. Markowitz GS, D'Agati VD (May 2009). "Classification of lupus nephritis". Curr. Opin. Nephrol. Hypertens. 18 (3): 220–5. PMID 19374008.
  7. Schwartz MM, Kawala KS, Corwin HL, Lewis EJ (August 1987). "The prognosis of segmental glomerulonephritis in systemic lupus erythematosus". Kidney Int. 32 (2): 274–9. PMID 3656940.
  8. 8.0 8.1 Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, Balow JE, Bruijn JA, Cook T, Ferrario F, Fogo AB, Ginzler EM, Hebert L, Hill G, Hill P, Jennette JC, Kong NC, Lesavre P, Lockshin M, Looi LM, Makino H, Moura LA, Nagata M (February 2004). "The classification of glomerulonephritis in systemic lupus erythematosus revisited". J. Am. Soc. Nephrol. 15 (2): 241–50. PMID 14747370.
  9. 9.0 9.1 Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, Balow JE, Bruijn JA, Cook T, Ferrario F, Fogo AB, Ginzler EM, Hebert L, Hill G, Hill P, Jennette JC, Kong NC, Lesavre P, Lockshin M, Looi LM, Makino H, Moura LA, Nagata M (February 2004). "The classification of glomerulonephritis in systemic lupus erythematosus revisited". Kidney Int. 65 (2): 521–30. doi:10.1111/j.1523-1755.2004.00443.x. PMID 14717922.

Template:WH Template:WS