Lobular carcinoma in situ: Difference between revisions

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*The pathogenesis of [disease name] is characterized by [feature1], [feature2], and [feature3].
*The pathogenesis of [disease name] is characterized by [feature1], [feature2], and [feature3].
*The loss of expression of [[e-cadherin]], the [[transmembrane]] [[protein]] mediating [[epithelial]] [[cell adhesion]] has been associated with the development of lobular carcinoma in situ.
*The loss of expression of [[e-cadherin]], the [[transmembrane]] [[protein]] mediating [[epithelial]] [[cell adhesion]] has been associated with the development of lobular carcinoma in situ.
*The loss of heterozygosity on chromosome 16q has been associated with the development of lobular carcinoma in situ.
*The loss of heterozygosity on chromosome 16q has been associated with the development of lobular carcinoma in situ..
*On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
*On microscopic histopathological analysis, small cells with oval or round nuclei and small nucleoli detached from each other are [[mucin]]-containing signet-ring cells are characteristic findings of lobular carcinoma in situ
*On microscopic histopathological analysis, small cells with oval or round nuclei and small nucleoli detached from each other are [[mucin]]-containing signet-ring cells are characteristic findings of lobular carcinoma in situ
==Causes==
==Causes==
* Lobular carcinoma in situ is caused by a mutation in the [[e-cadherin]] gene.
* Lobular carcinoma in situ is caused by a mutation in the [[e-cadherin]] gene.

Revision as of 21:14, 20 April 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]; Ammu Susheela, M.D. [3]

Synonyms and keywords: Synonym 1; Synonym 2; Synonym 3

Overview

Historical Perspective

  • Lobular carcinoma in situ was first discovered by F W Foote and F W Stewart, in 1941.

Pathophysiology

  • Lobular carcinoma in situ (LCIS) is a condition in which there is presence of unusual cells in the lobules of the breast.[1]
  • The pathogenesis of [disease name] is characterized by [feature1], [feature2], and [feature3].
  • The loss of expression of e-cadherin, the transmembrane protein mediating epithelial cell adhesion has been associated with the development of lobular carcinoma in situ.
  • The loss of heterozygosity on chromosome 16q has been associated with the development of lobular carcinoma in situ..
  • On microscopic histopathological analysis, small cells with oval or round nuclei and small nucleoli detached from each other are mucin-containing signet-ring cells are characteristic findings of lobular carcinoma in situ

Causes

  • Lobular carcinoma in situ is caused by a mutation in the e-cadherin gene.

Differentiating Lobular carcinoma in situ from other Diseases

  • Lobular carcinoma in situ must be differentiated from other diseases that cause breast lesions, such as:
  • Ductal carcinoma insitu
  • Atypical lobular hyperplasia

Epidemiology and Demographics

  • The prevalence of [disease name] is approximately [number or range] per 100,000 individuals worldwide.
  • In [year], the incidence of [disease name] was estimated to be [number or range] cases per 100,000 individuals in [location].

Age

  • Lobular carcinoma in situ is more commonly observed among patients aged premenopausal women with a mean age of 45 years old

Race

  • There is no racial predilection for [disease name].
  • [Disease name] usually affects individuals of the [race 1] race.
  • [Race 2] individuals are less likely to develop [disease name].

Risk Factors

  • Common risk factors in the development of [disease name] are [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].

Natural History, Complications and Prognosis

  • The majority of patients with [disease name] remain asymptomatic for [duration/years].
  • Early clinical features include [manifestation 1], [manifestation 2], and [manifestation 3].
  • If left untreated, [#%] of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
  • Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
  • Prognosis is generally [excellent/good/poor], and the [1/5/10year mortality/survival rate] of patients with [disease name] is approximately [#%].

Diagnosis

Diagnostic Criteria

  • The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met:
  • [criterion 1]
  • [criterion 2]
  • [criterion 3]
  • [criterion 4]

Symptoms

  • [Disease name] is usually asymptomatic.
  • Symptoms of [disease name] may include the following:
  • [symptom 1]
  • [symptom 2]
  • [symptom 3]
  • [symptom 4]
  • [symptom 5]
  • [symptom 6]

Physical Examination

  • Patients with [disease name] usually appear [general appearance].
  • Physical examination may be remarkable for:
  • [finding 1]
  • [finding 2]
  • [finding 3]
  • [finding 4]
  • [finding 5]
  • [finding 6]

Laboratory Findings

  • There are no specific laboratory findings associated with [disease name].
  • A [positive/negative] [test name] is diagnostic of [disease name].
  • An [elevated/reduced] concentration of [serum/blood/urinary/CSF/other] [lab test] is diagnostic of [disease name].
  • Other laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

Imaging Findings

  • There are no [imaging study] findings associated with [disease name].
  • [Imaging study 1] is the imaging modality of choice for [disease name].
  • On [imaging study 1], [disease name] is characterized by [finding 1], [finding 2], and [finding 3].
  • [Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].

Other Diagnostic Studies

  • [Disease name] may also be diagnosed using [diagnostic study name].
  • Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].

Treatment

Medical Therapy

  • There is no treatment for [disease name]; the mainstay of therapy is supportive care.
  • The mainstay of therapy for [disease name] is [medical therapy 1] and [medical therapy 2].
  • [Medical therapy 1] acts by [mechanism of action1].
  • Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].

Surgery

  • Surgery is the mainstay of therapy for [disease name].
  • [Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of [disease name].
  • [Surgical procedure] can only be performed for patients with [disease stage] [disease name].

Prevention

  • There are no primary preventive measures available for [disease name].
  • Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].
  • Once diagnosed and successfully treated, patients with [disease name] are followedup every [duration]. Followup testing includes [test 1], [test 2], and [test 3].

References

  1. "Lobular Carcinoma in situ (LCIS) - Breast Cancer - Stanford Cancer Center".