Light chain

An antibody molecule. The two heavy chains are colored red and blue and the two light chains green and yellow. See also:[1]

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Overview

A light chain is the small polypeptide subunit of an antibody (or immunoglobulin); a typical antibody is composed of two immunoglobulin (Ig) heavy chains and two Ig light chains.

In humans

There are two types of light chain in mammals,

• lambda (λ) chain (1, 2, 3, and 4)
• kappa (κ) chain (only one type)

In other animals

Other types of light chains can be found in lower vertebrates, such as the Ig-Light-Iota chain of Chondrichthyes and Teleostei.

Camelids are unique among mammals as they have fully functional antibodies which have two heavy chains, but lack the light chains usually paired with each heavy chain. The functional role of this separate repertoire is unknown as yet.

Structure

Only one type of light chain is present in a typical antibody, thus the two light chains of an individual antibody are identical.

Each light chain is composed of two tandem immunoglobulin domains:

• one constant (IgC) domain
• one variable domain (IgV) that is important for binding antigen

The approximate length of a light chain protein is from 211 to 217 amino acids.

External links

• MeSH Immunoglobulin+Light+Chains

Cost Effectiveness of Light chain

| group5 = Clinical Trials Involving Light chain | list5 = Ongoing Trials on Light chain at Clinical Trials.gov • Trial results on Light chain • Clinical Trials on Light chain at Google

| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Light chain | list6 = US National Guidelines Clearinghouse on Light chain • NICE Guidance on Light chain • NHS PRODIGY Guidance • FDA on Light chain • CDC on Light chain

| group7 = Textbook Information on Light chain | list7 = Books and Textbook Information on Light chain

| group8 = Pharmacology Resources on Light chain | list8 = AND (Dose)}} Dosing of Light chain • AND (drug interactions)}} Drug interactions with Light chain • AND (side effects)}} Side effects of Light chain • AND (Allergy)}} Allergic reactions to Light chain • AND (overdose)}} Overdose information on Light chain • AND (carcinogenicity)}} Carcinogenicity information on Light chain • AND (pregnancy)}} Light chain in pregnancy • AND (pharmacokinetics)}} Pharmacokinetics of Light chain •

| group9 = Genetics, Pharmacogenomics, and Proteinomics of Light chain | list9 = AND (pharmacogenomics)}} Genetics of Light chain • AND (pharmacogenomics)}} Pharmacogenomics of Light chain • AND (proteomics)}} Proteomics of Light chain

| group10 = Newstories on Light chain | list10 = Light chain in the news • Be alerted to news on Light chain • News trends on Light chain</small>

| group11 = Commentary on Light chain | list11 = Blogs on Light chain

| group12 = Patient Resources on Light chain | list12 = Patient resources on Light chain • Discussion groups on Light chain • Patient Handouts on Light chain • Directions to Hospitals Treating Light chain • Risk calculators and risk factors for Light chain

| group13 = Healthcare Provider Resources on Light chain | list13 = Symptoms of Light chain • Causes & Risk Factors for Light chain • Diagnostic studies for Light chain • Treatment of Light chain

| group14 = Continuing Medical Education (CME) Programs on Light chain | list14 = CME Programs on Light chain

| group15 = International Resources on Light chain | list15 = Light chain en Espanol • Light chain en Francais

| group16 = Business Resources on Light chain | list16 = Light chain in the Marketplace • Patents on Light chain

| group17 = Informatics Resources on Light chain | list17 = List of terms related to Light chain

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