LCP1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Plastin-2''' is a [[protein]] that in humans is encoded by the ''LCP1'' [[gene]].<ref name="pmid2111166">{{cite journal | vauthors = Zu Y, Kohno M, Kubota I, Nishida E, Hanaoka M, Namba Y | title = Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells | journal = Biochemistry | volume = 29 | issue = 4 | pages = 1055–62 | date = January 1990 | pmid = 2111166 | pmc = | doi = 10.1021/bi00456a030 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_LCP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2d85.
| PDB = {{PDB2|2d85}}
| Name = Lymphocyte cytosolic protein 1 (L-plastin)
| HGNCid = 6528
| Symbol = LCP1
| AltSymbols =; CP64; DKFZp781A23186; FLJ25423; FLJ26114; FLJ39956; L-PLASTIN; LC64P; PLS2
| OMIM = 153430
| ECnumber = 
| Homologene = 80174
| MGIid = 104808
| GeneAtlas_image1 = PBB_GE_LCP1_208885_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} {{GNF_GO|id=GO:0051015 |text = actin filament binding}}
| Component = {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0001891 |text = phagocytic cup}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005884 |text = actin filament}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0051017 |text = actin filament bundle formation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3936
    | Hs_Ensembl = ENSG00000136167
    | Hs_RefseqProtein = NP_002289
    | Hs_RefseqmRNA = NM_002298
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 45598060
    | Hs_GenLoc_end = 45654386
    | Hs_Uniprot = P13796
    | Mm_EntrezGene = 18826
    | Mm_Ensembl = ENSMUSG00000021998
    | Mm_RefseqmRNA = NM_008879
    | Mm_RefseqProtein = NP_032905
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 73870580
    | Mm_GenLoc_end = 73964963
    | Mm_Uniprot = Q3TJX0
  }}
}}
'''Lymphocyte cytosolic protein 1 (L-plastin)''', also known as '''LCP1''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Plastin]]s are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as [[fimbrin]]) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-[[hemopoietic]] origin suggesting that its expression is induced accompanying [[tumorigenesis]] in solid tissues.<ref name="entrez">{{cite web | title = Entrez Gene: LCP1 lymphocyte cytosolic protein 1 (L-plastin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3936| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.<ref name="entrez">{{cite web | title = Entrez Gene: LCP1 lymphocyte cytosolic protein 1 (L-plastin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3936| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Namba Y, Ito M, Zu Y, Shigesada K, Maruyama K | title = Human T cell L-plastin bundles actin filaments in a calcium-dependent manner | journal = Journal of Biochemistry | volume = 112 | issue = 4 | pages = 503–7 | date = October 1992 | pmid = 1491005 | doi =  }}
| citations =
* {{cite journal | vauthors = Zu YL, Shigesada K, Nishida E, Kubota I, Kohno M, Hanaoka M, Namba Y | title = 65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites | journal = Biochemistry | volume = 29 | issue = 36 | pages = 8319–24 | date = September 1990 | pmid = 2252891 | doi = 10.1021/bi00488a017 }}
*{{cite journal | author=Namba Y, Ito M, Zu Y, ''et al.'' |title=Human T cell L-plastin bundles actin filaments in a calcium-dependent manner. |journal=J. Biochem. |volume=112 |issue= 4 |pages= 503-7 |year= 1993 |pmid= 1491005 |doi=  }}
* {{cite journal | vauthors = Lin CS, Aebersold RH, Leavitt J | title = Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain | journal = Molecular and Cellular Biology | volume = 10 | issue = 4 | pages = 1818–21 | date = April 1990 | pmid = 2378651 | pmc = 362293 | doi =  }}
*{{cite journal | author=Zu Y, Kohno M, Kubota I, ''et al.'' |title=Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells. |journal=Biochemistry |volume=29 |issue= 4 |pages= 1055-62 |year= 1990 |pmid= 2111166 |doi= }}
* {{cite journal | vauthors = Lin CS, Aebersold RH, Kent SB, Varma M, Leavitt J | title = Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts | journal = Molecular and Cellular Biology | volume = 8 | issue = 11 | pages = 4659–68 | date = November 1988 | pmid = 3211125 | pmc = 365555 | doi =  }}
*{{cite journal | author=Zu YL, Shigesada K, Nishida E, ''et al.'' |title=65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites. |journal=Biochemistry |volume=29 |issue= 36 |pages= 8319-24 |year= 1991 |pmid= 2252891 |doi=  }}
* {{cite journal | vauthors = Matsushima K, Shiroo M, Kung HF, Copeland TD | title = Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1 | journal = Biochemistry | volume = 27 | issue = 10 | pages = 3765–70 | date = May 1988 | pmid = 3261603 | doi = 10.1021/bi00410a037 }}
*{{cite journal | author=Lin CS, Aebersold RH, Leavitt J |title=Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain. |journal=Mol. Cell. Biol. |volume=10 |issue= 4 |pages= 1818-21 |year= 1990 |pmid= 2378651 |doi=  }}
* {{cite journal | vauthors = Kondo I, Shin K, Honmura S, Nakajima H, Yamamura E, Satoh H, Terauchi M, Usuki Y, Takita H, Hamaguchi H | title = A case report of a patient with retinoblastoma and chromosome 13q deletion: assignment of a new gene (gene for LCP1) on human chromosome 13 | journal = Human Genetics | volume = 71 | issue = 3 | pages = 263–6 | year = 1986 | pmid = 3864729 | doi = 10.1007/BF00284588 }}
*{{cite journal | author=Lin CS, Aebersold RH, Kent SB, ''et al.'' |title=Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts. |journal=Mol. Cell. Biol. |volume=8 |issue= 11 |pages= 4659-68 |year= 1989 |pmid= 3211125 |doi= }}
* {{cite journal | vauthors = Arpin M, Friederich E, Algrain M, Vernel F, Louvard D | title = Functional differences between L- and T-plastin isoforms | journal = The Journal of Cell Biology | volume = 127 | issue = 6 Pt 2 | pages = 1995–2008 | date = December 1994 | pmid = 7806577 | pmc = 2120298 | doi = 10.1083/jcb.127.6.1995 }}
*{{cite journal | author=Matsushima K, Shiroo M, Kung HF, Copeland TD |title=Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1. |journal=Biochemistry |volume=27 |issue= 10 |pages= 3765-70 |year= 1988 |pmid= 3261603 |doi= }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Kondo I, Shin K, Honmura S, ''et al.'' |title=A case report of a patient with retinoblastoma and chromosome 13q deletion: assignment of a new gene (gene for LCP1) on human chromosome 13. |journal=Hum. Genet. |volume=71 |issue= 3 |pages= 263-6 |year= 1986 |pmid= 3864729 |doi= }}
* {{cite journal | vauthors = Lin CS, Shen W, Chen ZP, Tu YH, Matsudaira P | title = Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney | journal = Molecular and Cellular Biology | volume = 14 | issue = 4 | pages = 2457–67 | date = April 1994 | pmid = 8139549 | pmc = 358613 | doi = 10.1128/mcb.14.4.2457 }}
*{{cite journal | author=Arpin M, Friederich E, Algrain M, ''et al.'' |title=Functional differences between L- and T-plastin isoforms. |journal=J. Cell Biol. |volume=127 |issue= 6 Pt 2 |pages= 1995-2008 |year= 1995 |pmid= 7806577 |doi= }}
* {{cite journal | vauthors = Lin CS, Park T, Chen ZP, Leavitt J | title = Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells | journal = The Journal of Biological Chemistry | volume = 268 | issue = 4 | pages = 2781–92 | date = February 1993 | pmid = 8428952 | doi =  }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Lin CS, Chen ZP, Park T, Ghosh K, Leavitt J | title = Characterization of the human L-plastin gene promoter in normal and neoplastic cells | journal = The Journal of Biological Chemistry | volume = 268 | issue = 4 | pages = 2793–801 | date = February 1993 | pmid = 8428953 | doi =  }}
*{{cite journal | author=Lin CS, Shen W, Chen ZP, ''et al.'' |title=Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney. |journal=Mol. Cell. Biol. |volume=14 |issue= 4 |pages= 2457-67 |year= 1994 |pmid= 8139549 |doi=  }}
* {{cite journal | vauthors = Jones SL, Brown EJ | title = FcgammaRII-mediated adhesion and phagocytosis induce L-plastin phosphorylation in human neutrophils | journal = The Journal of Biological Chemistry | volume = 271 | issue = 24 | pages = 14623–30 | date = June 1996 | pmid = 8663066 | doi = 10.1074/jbc.271.24.14623 }}
*{{cite journal | author=Lin CS, Park T, Chen ZP, Leavitt J |title=Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. |journal=J. Biol. Chem. |volume=268 |issue= 4 |pages= 2781-92 |year= 1993 |pmid= 8428952 |doi=  }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Lin CS, Chen ZP, Park T, ''et al.'' |title=Characterization of the human L-plastin gene promoter in normal and neoplastic cells. |journal=J. Biol. Chem. |volume=268 |issue= 4 |pages= 2793-801 |year= 1993 |pmid= 8428953 |doi= }}
* {{cite journal | vauthors = Okumura Y, Yano M, Murakami M, Mori S, Towatari T, Kido H | title = The extracellular processing of HIV-1 envelope glycoprotein gp160 by human plasmin | journal = FEBS Letters | volume = 442 | issue = 1 | pages = 39–42 | date = January 1999 | pmid = 9923600 | doi = 10.1016/S0014-5793(98)01612-3 }}
*{{cite journal | author=Jones SL, Brown EJ |title=FcgammaRII-mediated adhesion and phagocytosis induce L-plastin phosphorylation in human neutrophils. |journal=J. Biol. Chem. |volume=271 |issue= 24 |pages= 14623-30 |year= 1996 |pmid= 8663066 |doi= }}
* {{cite journal | vauthors = Wang J, Brown EJ | title = Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A | journal = The Journal of Biological Chemistry | volume = 274 | issue = 34 | pages = 24349–56 | date = August 1999 | pmid = 10446213 | doi = 10.1074/jbc.274.34.24349 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Lin CS, Lau A, Yeh CC, Chang CH, Lue TF | title = Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences | journal = DNA and Cell Biology | volume = 19 | issue = 1 | pages = 1–7 | date = January 2000 | pmid = 10668786 | doi = 10.1089/104454900314654 }}
*{{cite journal | author=Okumura Y, Yano M, Murakami M, ''et al.'' |title=The extracellular processing of HIV-1 envelope glycoprotein gp160 by human plasmin. |journal=FEBS Lett. |volume=442 |issue= 1 |pages= 39-42 |year= 1999 |pmid= 9923600 |doi= }}
* {{cite journal | vauthors = Jia J, Han Q, Borregaard N, Lollike K, Cygler M | title = Crystal structure of human grancalcin, a member of the penta-EF-hand protein family | journal = Journal of Molecular Biology | volume = 300 | issue = 5 | pages = 1271–81 | date = July 2000 | pmid = 10903868 | doi = 10.1006/jmbi.2000.3925 }}
*{{cite journal | author=Wang J, Brown EJ |title=Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 24349-56 |year= 1999 |pmid= 10446213 |doi= }}
* {{cite journal | vauthors = Lollike K, Johnsen AH, Durussel I, Borregaard N, Cox JA | title = Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner | journal = The Journal of Biological Chemistry | volume = 276 | issue = 21 | pages = 17762–9 | date = May 2001 | pmid = 11279160 | doi = 10.1074/jbc.M100965200 }}
*{{cite journal | author=Lin CS, Lau A, Yeh CC, ''et al.'' |title=Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences. |journal=DNA Cell Biol. |volume=19 |issue= 1 |pages= 1-7 |year= 2000 |pmid= 10668786 |doi= 10.1089/104454900314654 }}
* {{cite journal | vauthors = Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y | title = Protein-protein interaction panel using mouse full-length cDNAs | journal = Genome Research | volume = 11 | issue = 10 | pages = 1758–65 | date = October 2001 | pmid = 11591653 | pmc = 311163 | doi = 10.1101/gr.180101 }}
*{{cite journal | author=Jia J, Han Q, Borregaard N, ''et al.'' |title=Crystal structure of human grancalcin, a member of the penta-EF-hand protein family. |journal=J. Mol. Biol. |volume=300 |issue= 5 |pages= 1271-81 |year= 2000 |pmid= 10903868 |doi= 10.1006/jmbi.2000.3925 }}
*{{cite journal | author=Lollike K, Johnsen AH, Durussel I, ''et al.'' |title=Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 17762-9 |year= 2001 |pmid= 11279160 |doi= 10.1074/jbc.M100965200 }}
*{{cite journal  | author=Suzuki H, Fukunishi Y, Kagawa I, ''et al.'' |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758-65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=3936}}


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{{gene-13-stub}}
 
[[Category:EF-hand-containing proteins]]

Latest revision as of 00:34, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Plastin-2 is a protein that in humans is encoded by the LCP1 gene.[1]

Function

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.[2]

References

  1. ↑ Zu Y, Kohno M, Kubota I, Nishida E, Hanaoka M, Namba Y (January 1990). "Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells". Biochemistry. 29 (4): 1055–62. doi:10.1021/bi00456a030. PMID 2111166.
  2. ↑ "Entrez Gene: LCP1 lymphocyte cytosolic protein 1 (L-plastin)".

Further reading


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