Intervention in left main coronary artery disease: Difference between revisions
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==Overview== | ==Overview== | ||
Left main coronary artery stenosis is associated with poor patient outcomes secondary to the ischemia of the large area of the myocardium which it supplies. Traditionally, [[CABG]] was indicated for left main disease. The [[SYNTAX]] trial demonstrated non-inferiority of [[PCI]] to [[CABG]] in a subgroup of patients with low to intermediate [[SYNTAX score#SYNTAX-Derived Risk Scores|SYNTAX score]]. This clinical trial suggests a possible indication for a [[PCI]] option for the treatment of left main disease. Subsequently, the PRECOMBAT trial was conducted to compare the two interventions in this particular subgroup. In 2016, two large trials results were published (EXCEL trial and NOBLE trial) to address the comparison of [[CABG]] and [[PCI]] in patients with left main disease and low to intermediate [[SYNTAX score#SYNTAX-Derived Risk Scores|SYNTAX score]]s. | Left main coronary artery stenosis is associated with poor patient outcomes secondary to the ischemia of the large area of the myocardium which it supplies. Traditionally, [[CABG]] was indicated for left main disease. The [[SYNTAX]] trial demonstrated non-inferiority of [[PCI]] to [[CABG]] in a subgroup of patients with low to intermediate [[SYNTAX score#SYNTAX-Derived Risk Scores|SYNTAX score]]. This clinical trial suggests a possible indication for a [[PCI]] option for the treatment of left main disease. Subsequently, the PRECOMBAT trial was conducted to compare the two interventions in this particular subgroup. In 2016, two large trials results were published (EXCEL trial and NOBLE trial) to address the comparison of [[CABG]] and [[PCI]] in patients with left main disease and low to intermediate [[SYNTAX score#SYNTAX-Derived Risk Scores|SYNTAX score]]s. | ||
==Left Main Disease | ==Left Main Disease Trials== | ||
===Synopsis=== | |||
===SYNTAX Trial=== | |||
===PRECOMBAT Trial=== | |||
===EXCEL Trial=== | |||
===NOBLE Trial=== | |||
==References== | ==References== |
Revision as of 00:44, 2 November 2016
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Tarek Nafee, M.D. [2]
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Overview
Left main coronary artery stenosis is associated with poor patient outcomes secondary to the ischemia of the large area of the myocardium which it supplies. Traditionally, CABG was indicated for left main disease. The SYNTAX trial demonstrated non-inferiority of PCI to CABG in a subgroup of patients with low to intermediate SYNTAX score. This clinical trial suggests a possible indication for a PCI option for the treatment of left main disease. Subsequently, the PRECOMBAT trial was conducted to compare the two interventions in this particular subgroup. In 2016, two large trials results were published (EXCEL trial and NOBLE trial) to address the comparison of CABG and PCI in patients with left main disease and low to intermediate SYNTAX scores.